Protein Alignment CG5521 and GARNL3

DIOPT Version :10

• Sequence 1: NP_001163748.1
• Gene: CG5521 / 43242
• FlyBaseID: FBgn0039466
• Length: 1964
• Species: Drosophila melanogaster
• Sequence 2: XP_005252324.1
• Gene: GARNL3 / 84253
• HGNCID: 25425
• Length: 1076
• Species: Homo sapiens
• Alignment Length: 638
• Identity: 125/638 - (19%)
• Similarity: 218/638 - (34%)
• Gaps: 205/638 - (32%)

  Fly  1392 GGITAGLVTADKQVRVLMRDLNGKACWDASILYSEPRNAEEPP--------KTTPKIQHSQPLDS 1448
            ||:.|.|:   :|.|..:|   .:.|     .:..||.|.:||        |.....|.:|.:..
Human     6 GGVAAALL---RQKRAALR---RRGC-----SFESPRTAAQPPGPLMDPLTKVPCGSQIAQTILW 59

  Fly  1449 MATSMVTHTPSPRHTLRHRPAGVLPL----AKDMAPDLDQLDDMLAYIGHTSPECVAPTVSQLNA 1509
            .|.|.::.             |:.||    .||  |:|:                     ||:|.
Human    60 KAKSSLSF-------------GIQPLQTWPTKD--PELE---------------------SQVNL 88

  Fly  1510 PTASPLS------GNQEAQAISVILNQ------------RLLEQEFVTHSTQAPSPALRHASSNS 1556
            ..:..|.      ..:...::.::::.            |:.......::|..|....|   ::.
Human    89 SVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRR---TDV 150

  Fly  1557 SLQQPDQRS----------LHSTTASFDSLPTRTEMPF---------------QYCRLLFSHLGL 1596
            .|:.|:..:          :|......|:    .:.||               ||..:|
Human   151 HLENPEYHTRWYFKYFLGQVHQNYIGNDA----EKSPFFLSVTLSDQNNQRVPQYRAIL------ 205

  Fly  1597 AGWERRSRTHL--------------------LQRSEKLMRELRNVDLQK----CRE-----THKM 1632
              |.:.....:                    |.:.||..||:.:.::||    ..|     ..|.
Human   206 --WRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVNFKF 268

  Fly  1633 AVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFLGGLPRQG--CGATAPYYATP 1695
            .|::...||.....:..|..||..::.|::.||..|.|:...|:.|||..:.  .|..:.|....
Human   269 GVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQ 333

  Fly  1696 FLEVVYHVATRMP-SDSSEAMLLKTRHLGNDEVHIVWSEHNRD---YRRDILPTEFCDVLIVV-Y 1755
            ..|:::||:|.:| |..::..:.:.||:|||.|.||:.|....   ::..::.:.|..:..:| |
Human   334 GHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRY 398

  Fly  1756 PLRNGLFRVTVNRKPEVPWFGP-------LANESVVSGACLATLIRA------TAINASRTKRAA 1807
            ..:|..:|:.:..:..||.|||       ..:........|..||..      |...|.:.:|..
Human   399 NQQNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTL 463

  Fly  1808 LPLYQQFYEE----------RNRSLDSV------SSRYKESTTFEDFASRIYNPMPLSTLGTLRE 1856
            ..|.:..:::          ..||...|      |:|.||.....:|. ||...:.|.   ::..
Human   464 DMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFV-RIGQALKLK---SIVR 524

  Fly  1857 SNASSSAAPLASAL--------------LDHNRASVKGWVQA---SIDSGPIM 1892
            .:|.||.|  ||.:              ..|.......|.||   |.|:|.::
Human   525 GDAPSSLA--ASGICKKEPWEPQCFCSNFPHEAVCADPWGQALLVSTDAGVLL 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	RALGAPB_N	491..619	CDD:466561
		Rap_GAP	1648..1820	CDD:460463	46/201 (23%)
GARNL3	XP_005252324.1	Rap_GAP	284..462	CDD:460463	44/177 (25%)
		CNH	561..859	CDD:459938	6/15 (40%)