Protein Alignment CG5521 and Sipa1l3

DIOPT Version :10

• Sequence 1: NP_001163748.1
• Gene: CG5521 / 43242
• FlyBaseID: FBgn0039466
• Length: 1964
• Species: Drosophila melanogaster
• Sequence 2: XP_006540460.1
• Gene: Sipa1l3 / 74206
• MGIID: 1921456
• Length: 1782
• Species: Mus musculus
• Alignment Length: 827
• Identity: 167/827 - (20%)
• Similarity: 266/827 - (32%)
• Gaps: 261/827 - (31%)

  Fly  1236 NEQGDTLVLQVLRVLLQVASGAPRHERVKLTADDDFDMHIAHDDLQGDGRLPEATYQTSETIQKC 1300
            :||.:....|.||.||||..||               :.......:||.|..:.|..:.:::|..
Mouse   221 SEQPEARGSQNLRELLQVDPGA---------------LSGGSCGTKGDPRNGQPTKDSLQSLQPL 270

  Fly  1301 ITAIKLCAKAVSMHLVTHIGHFPMGIGASRLSSMVEE------QDDIGNAAYGGQVETRRDSVEL 1359
            ....|...|.|.          .:|.|.:..||:..:      :.::|...  |:.|..|...|.
Mouse   271 KEKEKSRKKPVR----------GLGSGDTVDSSIFRKLRSSKPEGEVGRPL--GETEESRSPPEA 323

  Fly  1360 PSVVSAQNMQLFMLNSGLVASFIELPTLKLPGGGITAGLVTADKQVRVLMRDLNGKACWDASILY 1424
            ......|.            ||                   |...|:.::.|||..|....|:
Mouse   324 SRPWVCQK------------SF-------------------AHFDVQSMLFDLNEAAANRVSV-- 355

  Fly  1425 SEPRNAEEPPKTTPKIQHSQPLDSMATSMVTHTPSPRHTLRHRPAGVLPLAKDMAPDL------- 1482
            ::.||.     ||     .....|.|::|||.|.|..|:|     |.|..|.....||
Mouse   356 AQRRNT-----TT-----GASAASAASAMVTLTASRAHSL-----GTLDPAFTSTEDLNCKENLE 405

  Fly  1483 -----DQLDDMLAYIGHTSPECVAP---TVSQLNAPTASPLSGNQEAQAISVILNQRLLEQEFVT 1539
                 |..:|:|....|...|....   .||...|...|| .|:.||         .:.|....|
Mouse   406 QDLGDDNSNDLLLSCPHFRNEIGGERERNVSFSRASVGSP-GGSSEA---------HMAEPTLST 460

  Fly  1540 HSTQAPSPALRHASSNSSLQ-QPDQRSL------------------HSTTASFD------SLPTR 1579
            |.|.|....|.........| :|.|.|:                  |:.....|      ::..:
Mouse   461 HRTNASISVLEVPKEQQRTQSRPRQYSIEHVDLGARYYQDYFVGKEHANYFGVDEKLGPVAVSIK 525

  Fly  1580 TEM---------PFQYCRLLF---SHLGLAGWERRSRT--------------------------- 1605
            .|.         .:|| |::|   ..:.|.|......|
Mouse   526 REKLEDHKDHGPQYQY-RIIFRTRELITLRGSILEDATPTATKHGTGRGLPLKDALEYVIPELNI 589

  Fly  1606 HLLQ---RSEKLMRELRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWE 1667
            |.|:   .:.|:..:|..:|.|.....||:.::|..|||..:..:..|......:|.|:..||.:
Mouse   590 HCLRLALNTPKVTEQLLKLDEQGLCRKHKVGILYCKAGQSSEEEMYNNEEAGPAFEEFLDLLGDK 654

  Fly  1668 IDLETHNGFLGGL--PRQGCGATAPYYATPFLEVVYHVATRMP-SDSSEAMLLKTRHLGNDEVHI 1729
            :.|:....:...|  .....|..:.|......|:::||:|.:| :.::...||:.||:|||.|.|
Mouse   655 VCLKGFTKYAAQLDVKTDSTGTHSLYTTYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTI 719

  Fly  1730 VWSEHNRDYRRDILP-------TEFCDVLIVVYP----LRNGLFRVTVNRKPEVPWFGP------ 1777
            ::.|..      .||       :.|..|.|:|..    ..|..:.:.|.|..:.|.|||
Mouse   720 IFQEPG------ALPFTPKNIRSHFQHVFIIVRVHNPCTENVCYSMAVTRSKDAPPFGPPIPNGT 778

  Fly  1778 -LANESVVSGACLATLIRATAINASRTKRAALPLYQQFYEERNRSLDSVSSRYKESTTFEDFASR 1841
             .....|.....||.:|.|.  ||:               .::....::::|.::. ..:|.|..
Mouse   779 TFRKSDVFRDFLLAKVINAE--NAA---------------HKSDKFHTMATRTRQE-YLKDLAEN 825

  Fly  1842 IYNPMPLSTLGTL---------RESNASSSAAPLASALLDHNRASVKGWVQAS-ID--------- 1887
            ..:..|:.:.|..         :|...:.:.|...||.....|.:.:.:.|.| ||
Mouse   826 CVSNTPIDSSGKFNLISLTSKKKEKTKARAGAEQHSAGAIAWRVAAQDYAQGSEIDCILGISNEF 890

  Fly  1888 ----------------SGPIMGIAPSASA-------GSTAAMEAATG 1911
                            .|.::|..|.:|.       |....::||.|
Mouse   891 VVLLDLRTKEVVFNCYCGDVIGWTPDSSTIKIFYGRGDHIFLQAAEG 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	RALGAPB_N	491..619	CDD:466561
		Rap_GAP	1648..1820	CDD:460463	44/192 (23%)
Sipa1l3	XP_006540460.1	Rap_GAP	635..815	CDD:460463	45/202 (22%)
		PDZ_SIPA1-like	960..1032	CDD:467227
		PHA03247	<1131..1706	CDD:223021
		SPAR_C	1471..1721	CDD:463383