DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5521 and SIPA1

DIOPT Version :9

Sequence 1:	NP_001163748.1	Gene:	CG5521 / 43242	FlyBaseID:	FBgn0039466	Length:	1964	Species:	Drosophila melanogaster
Sequence 2:	NP_006738.3	Gene:	SIPA1 / 6494	HGNCID:	10885	Length:	1042	Species:	Homo sapiens

Alignment Length:	684	Identity:	143/684 - (20%)
Similarity:	243/684 - (35%)	Gaps:	143/684 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1323 PM---GIGASRLSSMVEEQDDIGNAAYGGQVETRRDSVELPSVVSAQNMQLFMLNSGLVASFIEL 1384
            ||   |:|:.|........||:    :..::.........|.....:.::..:|.||..|.....
Human     2 PMWAGGVGSPRRGMAPASTDDL----FARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARP 62

  Fly  1385 PTLKLPGGGITAGLVTADKQVRVLMRDLNGKACWDASILYSEP-----RNAEEPPKTTPKIQHSQ 1444
            ||             .|..:.|....:...:....::.|:::|     ..||||....|.:...:
Human    63 PT-------------PASPRARAHSHEEASRPAATSTRLFTDPLALLGLPAEEPEPAFPPVLEPR 114

  Fly  1445 PLDSMATSMVTHTPSPR------HTLRHRPAGVLPLAKDMAPDLDQLDDMLAYIGHTSPECVAPT 1503
            .........:....:||      |:  ...:|.|..|:|.|...|.|        |.:|..|...
Human   115 WFAHYDVQSLLFDWAPRSQGMGSHS--EASSGTLASAEDQAASSDLL--------HGAPGFVCEL 169

  Fly  1504 VSQ----LNAPTASPLSGNQEAQAISVILNQRLLEQEFVTHSTQAPSPALRHASSNS-------- 1556
            ..:    |..|.:.|:.......|:|::        |...:.|.|.|  |.||...:
Human   170 GGEGELGLGGPASPPVPPALPNAAVSIL--------EEPQNRTSAYS--LEHADLGAGYYRKYFY 224

  Fly  1557 -------------------SLQQPDQR-----SLHS--------------TTASFDSL---PTRT 1580
                               ||::.::.     :|||              .|.|.|:|   |.|.
Human   225 GKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDALPPGPPRG 289

  Fly  1581 EMPFQYCRLLFSHLGLAGWERRSRTHLLQRSEKLMRELRNVDLQKCRETHKMAVIYVAAGQEDKG 1645
            ..|    |.|..|  :|.....|...|...|.|:.|.|..:|.|......|:.::|..|||..:.
Human   290 LSP----RKLLEH--VAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE 348

  Fly  1646 SILRNTSGSSTYEMFVSALGWEIDLETHNGFLGGLPRQ--GCGATAPYYATPFLEVVYHVATRMP 1708
            .:..|......:..|::.||..:.|:....:...|..:  ..|..:.|......|:::||:|.:|
Human   349 EMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLP 413

  Fly  1709 -SDSSEAMLLKTRHLGNDEVHIVWSE-HNRDYRRDILPTEFCDVLIVVYP----LRNGLFRVTVN 1767
             :.:::..||:.||:|||.|.||:.| .::.:....:.:.|..|.:||..    ..:..:||.|:
Human   414 YTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVS 478

  Fly  1768 RKPEVPWFG---PLANESVVSGACLATLIRATAINASRTKRAALPLYQQFYEERNRSLDSVSSRY 1829
            |..:.|.||   |.......:.|.....:.|.|:|..:....|...:......|.:.|..:::.
Human   479 RTQDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATN- 542

  Fly  1830 KESTTFEDFASRIYNPMPLSTLGTLRESNASSSAAPLASALLDHNRASVKGWVQASIDSGPIMGI 1894
            :.:||..|.|||    ..|.:||..|.:......|.|.:|          |.:...:.:.|...:
Human   543 EVTTTSLDSASR----FGLPSLGGRRRAAPRGPGAELQAA----------GSLVWGVRAAPGARV 593

  Fly  1895 APSASAGSTAAME-------AATGMSSASPRGPR 1921
            |..|.|.....:|       :|..:...:||..|
Human   594 AAGAQASGPEGIEVPCLLGISAEALVLVAPRDGR 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	Rap_GAP	1648..1820	CDD:280332	42/182 (23%)
SIPA1	NP_006738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..87		16/101 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..153		5/22 (23%)
		Rap_GAP	351..532	CDD:396632	41/180 (23%)
		PDZ	687..759	CDD:395476
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..903
		Smc	<905..>1027	CDD:224117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..980
		ZapB	974..1030	CDD:399182
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810