DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5521 and RAP1GAP

DIOPT Version :9

Sequence 1:	NP_001163748.1	Gene:	CG5521 / 43242	FlyBaseID:	FBgn0039466	Length:	1964	Species:	Drosophila melanogaster
Sequence 2:	NP_001375129.1	Gene:	RAP1GAP / 5909	HGNCID:	9858	Length:	842	Species:	Homo sapiens

Alignment Length:	472	Identity:	104/472 - (22%)
Similarity:	163/472 - (34%)	Gaps:	134/472 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1613 KLMRELRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFL 1677
            |..|.:...|........|..|||...||..:..:......|..:..|:..||.::.|:...||.
Human   176 KASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR 240

  Fly  1678 GGL--PRQGCGATAPYYATPFLEVVYHVATRMPSDSSEA-MLLKTRHLGNDEVHIVWSEHNRDYR 1739
            |||  .....|..:.|......|:::||:|::|....:| .|.:.||:|||.|.:|:.:.|..:.
Human   241 GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFV 305

  Fly  1740 RDILPTEFCDVLIVVYPLRNG----LFRVTVNRKPEVPWFGPLANESVV--SGACLATLIRATAI 1798
            .|::.:.|....:||.....|    |::|:|..:.:||:|||...:..|  .|......:....|
Human   306 PDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLI 370

  Fly  1799 NA--------------SRTKRAAL-PLYQQ--------------------------FYE------ 1816
            ||              .||:.|.| .||::                          |:|
Human   371 NAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMENGSGGGGFFESFKRVI 435

  Fly  1817 -ERNRSLDSVSSRYKESTTFEDFASRIYNPMPLSTLGTLRESNASSSAAPLASALLDHNRASVKG 1880
             .|::|:|::....|:.           |.:..|..|:...:|...:.|...|.|:....||..|
Human   436 RSRSQSMDAMGLSNKKP-----------NTVSTSHSGSFAPNNPDLAKAAGISLLIPGKSASRFG 489

  Fly  1881 WVQASIDSGPIMGIAPSASAGSTAAMEA-------------------------ATGMSSASPRGP 1920
            ...::|..|.:..:....:|||...:.|                         ..|.|..|..|.
Human   490 RRGSAIGIGTVEEVVVRGAAGSGGCLHALFSARSQDGGHIGDVAPLPPGQAPGRAGWSGGSSDGT 554

  Fly  1921 R------KLGAPFKSVTKKH-----SLQHIAVG-----------GGAGAGGDTP----------- 1952
            :      .|..|.||.|:|.     |.:..|:|           ....||..||
Human   555 QHLLWGLSLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKS 619

  Fly  1953 --------PESPTLPQR 1961
                    ||.||...|
Human   620 ENSSTQSSPEMPTTKNR 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	Rap_GAP	1648..1820	CDD:280332	54/228 (24%)
RAP1GAP	NP_001375129.1	GoLoco	<1..17	CDD:214645
RAP1GAP	NP_001375129.1	Rap_GAP	211..390	CDD:396632	46/178 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810