DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5521 and SIPA1L2

DIOPT Version :9

Sequence 1:	NP_001163748.1	Gene:	CG5521 / 43242	FlyBaseID:	FBgn0039466	Length:	1964	Species:	Drosophila melanogaster
Sequence 2:	NP_065859.3	Gene:	SIPA1L2 / 57568	HGNCID:	23800	Length:	1722	Species:	Homo sapiens

Alignment Length:	314	Identity:	71/314 - (22%)
Similarity:	121/314 - (38%)	Gaps:	33/314 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1611 SEKLMRELRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLETHNG 1675
            |.|:..:|..:|.|.....||:.::|..|||..:..:..|.:....:|.|:..||..:.|:..:.
Human   588 SPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSK 652

  Fly  1676 FLGGLPRQ--GCGATAPYYATPFLEVVYHVATRMP-SDSSEAMLLKTRHLGNDEVHIVWSEHNR- 1736
            :...|..:  ..|..:.|......|:::||:|.:| ..::...||:.||:|||.|.||:.|...
Human   653 YRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGAL 717

  Fly  1737 DYRRDILPTEFCDVLIVVYP----LRNGLFRVTVNRKPEVPWFGPLANESVV--SGACLATLIRA 1795
            .:....:.:.|..|.::|..    ..|..:.|.|:|..:||.|||...:.|.  ..|.....:.|
Human   718 PFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLA 782

  Fly  1796 TAINASRTKRAALPLYQQFYEERNRSLDSVSSRYKESTTFEDFASRIYNPMPLSTLGTLRESNAS 1860
            ..|||......:..........|...|..::..:..:.|.:....     ....|||..::....
Human   783 KVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVK-----FSFITLGAKKKEKVK 842

  Fly  1861 SSAAPLASALLDHNRASVKGWVQASIDSGPIMGIAPSASAGSTAAMEAATGMSS 1914
                |...|.|              ...|.||....:...|.:|.:|...|:|:
Human   843 ----PRKDAHL--------------FSIGAIMWHVIARDFGQSADIECLLGISN 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	Rap_GAP	1648..1820	CDD:280332	44/181 (24%)
SIPA1L2	NP_065859.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..72
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..401
		Rap_GAP	625..805	CDD:280332	43/179 (24%)
		PDZ_signaling	950..1020	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1067..1245
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1330..1360
		SPAR_C	1423..1666	CDD:288714
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910