Protein Alignment CG5521 and ralgapa1

DIOPT Version :9

• Sequence 1: NP_001163748.1
• Gene: CG5521 / 43242
• FlyBaseID: FBgn0039466
• Length: 1964
• Species: Drosophila melanogaster
• Sequence 2: XP_021322984.1
• Gene: ralgapa1 / 556427
• ZFINID: ZDB-GENE-080806-1
• Length: 2518
• Species: Danio rerio
• Alignment Length: 2637
• Identity: 751/2637 - (28%)
• Similarity: 1107/2637 - (41%)
• Gaps: 875/2637 - (33%)

  Fly     1 MFTKKSHADVKKSTAKLQDSKKDSASRLRHLRMILDNVELEESKCLFETNYSHVYFILYDTFIQA 65
            ||:||.|.||:|||.|:.|.|||..:||:|||::::|.|..|.|.|||.||||:|::.::.|:..
Zfish     1 MFSKKPHGDVRKSTQKVLDPKKDVLTRLKHLRIVIENAESAELKHLFEQNYSHIYYVFFENFVTI 65

  Fly    66 EANLKQKELPFHIVHKAHREELDGSLWLLEKILCLLPELLARRWQCHSLSRIMAKLLHLGNSPKL 130
            |.|||||.      ||:.|||||..|::.||||.||||.:..|||.||:..|:.||||.|||.|:
Zfish    66 EVNLKQKG------HKSQREELDSILFIFEKILQLLPERIQGRWQFHSIGLILKKLLHTGNSLKI 124

  Fly   131 RREGVRYFLLWYQTLGENAPGYVHAMYADLIPGLIVPQKGVVGPDTEFSASDFLTHPNMKADGGM 195
            ||||||.||||.|.|..||......::|.||||...|| ..:||.|
Zfish   125 RREGVRLFLLWMQALQHNALREQLWIFACLIPGFPAPQ-SELGPRT------------------- 169

  Fly   196 ASVFHDNAFSHP-------VQSSEVVALLPPSSSEKSAPPDPRDGLEVLLNSMVHTAACLRWRDN 253
                .||..|.|       |...|:..|:||.|.:||........||.||..||:.|..|.|
Zfish   170 ----LDNLISPPLNLQEPQVTPEEISPLVPPQSGDKSQEDLTGYFLEALLKYMVNQAKSLEW--- 227

  Fly   254 RAQKDH-RAFAFLLQRFMDVFLPVFSPNFDVSCSIYNPRLDLPVMR-----SINKKE-------- 304
            :.:::| :.||||...|...:||...|||....|:|||.|::|.||     .:.|::
Zfish   228 KCKENHEKGFAFLFANFKKYYLPHIFPNFSKETSLYNPILEVPPMRPKPYYMVVKRDPETNEALY 292

  Fly   305 ---EVMASCVVVLINWVSRF--------------------------------------------- 321
               |...:..|:.|.|:..|
Zfish   293 CTKENFLNARVIFIRWLVSFWLEPRSNTGTQIPGMEGENVPKNIQRAAAGLAARGEDGGPRQDSL 357

  Fly   322 ----------TH-------ERLLSHRLDCTL---HIEDVDQVRLHGYQQGLIVRDVLYVNRENIN 366
                      :|       ||..|....|::   |:.|::           :||.||..:|.|:|
Zfish   358 DGGGIGEPEQSHSNTSTLTEREPSSSSLCSMDEEHLTDIE-----------VVRRVLCSSRTNVN 411

  Fly   367 FVHEVYRQAFLLNFTSKPQIE--AIRTAIAVYRDWMTGETPPPFLLEPND--------------- 414
            |:.|::||||||     |..|  |:|..:.||::|::.:..|.|:.:|.:
Zfish   412 FITEIFRQAFLL-----PMCEAAAMRKVVRVYQEWISQQDKPVFMRQPEEERFTGQLDSTHEQRA 471

  Fly   415 DPPPPSNAGGTPRSQRLRTPSYVGAIAGSKDQLVVRAGRQNVLQVFVTNAANVFLVNTANLNICF 479
            |.....:.|.|   ..:|.|:: .....|..:..|.||.|..||||:||::||||:..||
Zfish   472 DKDEEEDVGLT---VSVRNPNW-SRSKSSDSEYNVHAGVQATLQVFITNSSNVFLLEAAN----- 527

  Fly   480 PTRSRSYRSTPLEEQTEICKKVLNVYRTMVMNTEMDTRTWEQLLMVLLQVTSIVLHQNQHTLPSG 544
                 ..:|. |||..::||:|||:||::||:..|:.:||||:|:|||:||..|:.:....:|.|
Zfish   528 -----ELKSL-LEEHVDMCKRVLNIYRSLVMHETMNQKTWEQILLVLLRVTECVMKRPPSIMPHG 586

  Fly   545 TNKSATLGGILGSAIFQTLIVTWIRAHTKVPVNVLLWEKFLNVLQSLTHREELIIEWNKTIQTLT 609
             .||:||.|.|..||||||||.||:.:..|.::..||:..|:||.|||..|||:.||:.|::|||
Zfish   587 -KKSSTLSGRLAGAIFQTLIVAWIKGNLNVYISRELWDDLLSVLSSLTCWEELVTEWSLTMETLT 650

  Fly   610 RVFSRYTYGINLLDLPLDRVAESRAEKRRRIGSVWQGS-----------------GSNSAANGGS 657
            :|.:|..|.::|.:||||:::|.:.:|.:..|.:.:|.                 |..:|....|
Zfish   651 KVLARNLYSLDLNELPLDKLSEQKQKKHKGKGGIHEGQKITVDRSFSKGWSRDPPGQAAAMRQRS 715

  Fly   658 AASA-------AISQNRQR----------ESLAESS----------------------------- 676
            |.:|       |.|..||:          :||..|:
Zfish   716 ATTAGSPGIEKARSIVRQKTVALRSCSTGDSLLSSAFIRSAKSAPVLIHPVHPLLPDSVLTPLAD 780

  Fly   677 -------------------SSRSEETSS-----------QVPLPN-------------------- 691
                               .|:||||.:           |.|||.
Zfish   781 ELSDLEEPPMIQRGPRNRHCSQSEETPTSEVFSASGELEQPPLPRSSSASDIMEPFIAERAKGAL 845

  Fly   692 ----------------------HPRPHHQ------------------------------------ 698
                                  |..|:.|
Zfish   846 PVSDSPSHSPHFTATTTTIEFPHSSPNPQQLTDPQQLPDSQASLEVAESIYDHLCQMPGQQPPFI 910

  Fly   699 ----------------------------------------------------------------- 698
                                                                             
Zfish   911 PDWSCPAAASANQPEGEAEEDVFSAFREFCHRENVKMEAGADLKQVQFEGDWALEWDREMEQSEK 975

  Fly   699 ----------------------------------------------------------------- 698
                                                                             
Zfish   976 SLYECLEECDWDLSVSPQPAEDGKGAQLQRQDATDRASESEVSPQASHGPMLSNIDHKKRHSSAV 1040

  Fly   699 ------------------------------------HTQSQGGTGHGT----------------- 710
                                                |:....|.|.|.
Zfish  1041 HVSFRPSTESVLFHNPLDPKEAHWKTRLRRLGHFSSHSVGAKGVGEGVTCCEVVERERGSISGAR 1105

  Fly   711 -----RPIPLTPMLSRSYSEGSLASAARSSRIR----------------RRRAATPKPKALQPSQ 754
                 || .|.|..|||.|:.|..|.:|..::.                :.:||:|:..:..|:.
Zfish  1106 RGRLGRP-TLRPRGSRSRSQESGCSPSRQQQVALLGGVYKSMVHALSKPKGQAASPQRHSKSPAT 1169

  Fly   755 LA--------------------ENRINP------------------------QDLRRAMSLDSLA 775
            .|                    ::.:.|                        |:..||.....:.
Zfish  1170 EAHLKDLYASVMGYFGRKTSANKDELTPKMRPMSNDAGSSNPNVSDLMDEFIQERLRARGNSGMT 1234

  Fly   776 RKGDA-----------------------------------------------EETDSYQ------ 787
            |:|.:                                               .::||:.
Zfish  1235 RRGSSPGSLEIPKDLPELLNRQNATRPADDPGVPSEWTSPASASGSDLISSDSQSDSFNAFQYDS 1299

  Fly   788 -----------------EGDNESG-------------------------------------AGSR 798
                             :.|:.||                                     .||.
Zfish  1300 KFENFSFPPETCALASADQDSLSGTGQTAEEQELSSLTTLHIDSETSSLSQHGLSADTVTITGSE 1364

  Fly   799 SPSPTASSG-----------IEGGSIKDAQLQIDASL--------DDANSGSYGSGSNSGSISGR 844
            |.||..|.|           :....::..:||:|..:        ||..:..:.:...|
Zfish  1365 SASPMHSLGGSRSQTPSPATLTAEHVQHKELQLDEKMHHSVLQTPDDLETSEFPTEDCS------ 1423

  Fly   845 RCIILGGSAEGWHPDSTSIMWKRMLGALGDVNRIPKADLHAQVFMHLLEMTQNLIKIKQNQGIST 909
              ::.||:..|||.|..::||:||||.|||||.|...::|||||.:|.|:.|||.||:.|.|||.
Zfish  1424 --VMAGGTLTGWHADVATVMWRRMLGILGDVNYIKDPEIHAQVFDYLCELWQNLAKIRDNLGISL 1486

  Fly   910 DNQNTQPMPPLVPPIGIVAPWCYGSLSLDRSFKKGKLWALQLLCSLAIQG---AVNMQQLPLFYH 971
            |||::.|.|.|:||:.|:.||.:.:..|...:|:|||.|.:|:|.:..:.   :.|...|..||:
Zfish  1487 DNQSSPPPPDLIPPLRILTPWLFKATMLGERYKQGKLHAYKLICKIMKRRQDVSPNSDFLTHFYN 1551

  Fly   972 ALHQLLTGEDRDLIYAILKHLEGPRLLSLLLPGHTLLLLD-LVHASAILLTSLEVSRSTPRAEVA 1035
            .:|..|..:|:|::..|:||. .||..|:.|||.|:|:|| :|.||.:...|   |.:.||.|..
Zfish  1552 IMHCGLLHQDQDIVNTIIKHC-SPRFFSIGLPGATMLILDFIVAASRVTACS---SLNAPRVEAQ 1612

  Fly  1036 ALLGSLLCYPSSLLTRSVLQPTPQKFELMECSDLQDHILNIVLRCARREPSAKARCIALSQLGQW 1100
            .|||||:|.|:.......|.||.....:.:.:|:::||:..:|..||.||||.|||:||..||.|
Zfish  1613 ILLGSLVCLPNLYNELPALHPTTADIIMTKFTDVKEHIIKHILTSARDEPSAPARCVALCSLGIW 1677

  Fly  1101 LLMRLSQPLPASNSGRANLFQQAVPHHKDVHPKASSVYNPRIKEVLQVLLQALQFKHHTIAIVAV 1165
            |...|                        ||    ...:|:|||.|.|:...|:|.:..:|:||.
Zfish  1678 LCEEL------------------------VH----GTQHPQIKEALNVICVTLKFSNKNVALVAS 1714

  Fly  1166 DSLKLCAERGRQLAAI-----ERVPQLIITAICKALEIQSVTKPKDSDKVVLTSLMLCLGEFCMA 1225
            |.|.|......:|...     :::.:::|..|...|. .:.:.|.:.||.::.||:|||.::.||
Zfish  1715 DILHLLINYVDELEKFPPNTPKKIVEVLIATITYLLP-ATESSPHELDKRLVVSLLLCLLDWVMA 1778

  Fly  1226 IPAPIMLTPF-----NEQGDTLVLQ-VLRVLLQVASGA-----PRHERVKLT--ADDDFDMHIAH 1277
            :|...:|.|.     .|:.|..||. :.:||.....||     |.:..:.|:  :..|:|..:..
Zfish  1779 LPPKTLLQPVQGASDKEKTDKSVLSCIYKVLHGCVYGAQSFSNPSYFPIHLSDLSSPDYDPFLLL 1843

  Fly  1278 DDLQGDGRLPEATYQTSETIQKCITAIK---------LCAKAVSMHLVTHIGHFPMGIGASRLSS 1333
            ::|:....|.....:.|..:|. :|.::         :.|:.|..|||.|:||:||..|.:.|:|
Zfish  1844 ENLKEPEPLHSPDSERSSKLQP-VTEVRSRIQQGLVSVAARTVISHLVNHLGHYPMSGGPATLTS 1907

  Fly  1334 MVEEQDDIGNAAYGGQVETRRDSVEL-PSVVSAQNMQLFMLNSGLVASFIELPTLK-LPGGGITA 1396
            .|.|..|          ....:|.:| |.:..|.|:|.|:||...:.|::::.... |||||::|
Zfish  1908 QVCENQD----------NPYSESADLTPELFDAPNLQFFVLNGTTLLSYLQIRAEDGLPGGGMSA 1962

  Fly  1397 GLVTADKQVRVLMRDLNGKACWDASILYSEP-----------------------------RNAEE 1432
            ||.|.:..|||::||::||..||:::||..|                             |.::|
Zfish  1963 GLTTTNACVRVIVRDISGKHSWDSAVLYGPPHCITPSQTLHLYTSSNPRGEHNRDEDSLERGSQE 2027

  Fly  1433 PPKTTPKIQHSQPLDSMATSMVTHTPSPRHTL------------------RHRPAGVLPLAKDMA 1479
            .|:.....:..:.||....:.|.........|                  :.|...|:|....:.
Zfish  2028 EPEDGAFQESEEDLDEHEEAEVKEDEVEEEELEEEIEEEEVALELMAPQAKRRCREVIPNWDSLQ 2092

  Fly  1480 PDLDQLDDMLAYIGHTSPECVAPTVSQLNAPTASP--LSGNQEAQAISVILNQRLLEQEFVTHST 1542
            ...|.||:||.|:|::||||:..|...||.|...|  :|..||...|:.||.|...||:|..|..
Zfish  2093 DGEDSLDEMLQYLGYSSPECLQRTGGPLNIPAPPPNCVSEKQENDVINAILKQCAEEQDFTIHRG 2157

  Fly  1543 QAPSPALRHASSNSSLQQPDQRSLHSTTASFDSLPTRTEMPFQYCRLLFSHLGLAGWERRSRTHL 1607
                   ...:..:.:||             :..|.|.:..|.||:||.:.||:..||:|:..||
Zfish  2158 -------NELNMRAVVQQ-------------EPSPQRPQSAFYYCKLLLNILGMNSWEKRNSFHL 2202

  Fly  1608 LQRSEKLMRELRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLET 1672
            |:::|||:|||:|:|.::||||||:||.|||.|||||.|||.||:||..||.|||.||||::|.:
Zfish  2203 LKKNEKLLRELKNLDSRQCRETHKIAVFYVAEGQEDKHSILSNTAGSQAYEDFVSGLGWEVNLTS 2267

  Fly  1673 HNGFLGGLPR-QGCGATAPYYATPFLEVVYHVATRMPSDSSEAMLLKTRHLGNDEVHIVWSEHNR 1736
            |.||:|||.| :..|.|.||:||..:||::||:||||.||.:::..|.|||||||||||||||:|
Zfish  2268 HCGFMGGLQRNKSTGFTMPYFATSTVEVMFHVSTRMPPDSDDSLTKKLRHLGNDEVHIVWSEHSR 2332

  Fly  1737 DYRRDILPTEFCDVLIVVYPLRNGLFRVTVNRKPEVPWFGPLANESVVSGACLATLIRATAINAS 1801
            ||||.::||||.|||||:||::|.::.:.:.:|||||:||||.:.::|.|..|.|::||||||||
Zfish  2333 DYRRGVIPTEFGDVLIVIYPMKNHMYSIQIIKKPEVPFFGPLFDGAIVDGTILPTVVRATAINAS 2397

  Fly  1802 RTKRAALPLYQQFYEERNRSLDSVSSRYKESTTFEDFASRIYNPMPLSTLGTLRESNASSSAAPL 1866
            |..::.:||||.|||||.|.|:::...:.|.|||||:|:|::.|.|...|.:..|.|| ....||
Zfish  2398 RALKSLIPLYQNFYEERARYLETIVQHHLEPTTFEDYAARVFCPAPFHYLPSEAERNA-VIFLPL 2461

  Fly  1867 ASALLDH-NRASVKG-WVQASIDSGPIMGIAPSASAG 1901
            ....|:: ....||| .::..:.......:.|..|||
Zfish  2462 PKPPLENIGLTKVKGKGLKRKVFHASCEWLMPRESAG 2498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	Rap_GAP	1648..1820	CDD:280332	102/172 (59%)
ralgapa1	XP_021322984.1	Atrophin-1	<708..928	CDD:331285	23/219 (11%)
		Dendrin	1095..>1173	CDD:317849	16/78 (21%)
		Rap_GAP	2243..2416	CDD:307998	102/172 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577686
Domainoid	1	1.000	851	1.000	Domainoid score	I57
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H84805
Inparanoid	1	1.050	1103	1.000	Inparanoid score	I226
OMA	1	1.010	-	-		QHG47016
OrthoDB	1	1.010	-	-		D157372at2759
OrthoFinder	1	1.000	-	-		FOG0003646
OrthoInspector	1	1.000	-	-		otm26499
orthoMCL	1	0.900	-	-		OOG6_103120
Panther	1	1.100	-	-	O	PTHR10063
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2517
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770