Protein Alignment CG5521 and sipa1l2

DIOPT Version :10

• Sequence 1: NP_001163748.1
• Gene: CG5521 / 43242
• FlyBaseID: FBgn0039466
• Length: 1964
• Species: Drosophila melanogaster
• Sequence 2: XP_009304425.1
• Gene: sipa1l2 / 497350
• ZFINID: ZDB-GENE-050208-66
• Length: 1689
• Species: Danio rerio
• Alignment Length: 787
• Identity: 157/787 - (19%)
• Similarity: 276/787 - (35%)
• Gaps: 248/787 - (31%)

  Fly  1236 NEQGDTLVLQVLRVLLQVASGAPRHERVKLTADDDFDMH---------IAHDDLQGDGRLPEATY 1291
            :|:|:|.:.:.|:.:        :.|:.:|:..||...|         .:|.|:|      ...:
Zfish   239 SEKGETSIFRRLKTM--------KSEQRQLSELDDCSRHGRPLSFQRCFSHYDVQ------SVLF 289

  Fly  1292 QTSETI--------QKCITAIKLCAKAVSMHLVTHI--GHFPMGIGASRLSSMVEEQDDIGNAAY 1346
            ..||.:        :|.||.   .|.|.|.|.::..  |..|:.:..|.|.:.    :::|..|.
Zfish   290 NISEAVTNRANLARRKNITT---GASAASQHQISGALDGPDPLPLCESPLDNC----EELGQKAC 347

  Fly  1347 GGQVETRRDSVELPSVVSAQNMQLFMLNSGLVASFIELPTLKLPGGGITAGLVTADKQVRVLMRD 1411
            ....|                                       |.|.::|||.:....|   .:
Zfish   348 TDPDE---------------------------------------GDGKSSGLVLSCPYFR---NE 370

  Fly  1412 LNGKACWDASILYSEPRNAEEPPKTTPKIQHSQPLDSMATSMVTHTPSPRHTLRHRPAGVLPL-- 1474
            :.|:.  :..:..::|.:|  ||.:  .:..:..::|..:|..|:            |||..|
Zfish   371 IGGEG--ERKLNATKPNSA--PPNS--NVGDNNSIESTLSSHCTN------------AGVSVLEM 417

  Fly  1475 -------AKDMAPDLDQLD-------DMLAYIGHTSPECVAPTVSQLNAPTASPLSGNQEAQAIS 1525
                   .::.|...|.:.       ||.||..|.         ...|....:....::....::
Zfish   418 SRENYASRENYAIPRDCIKRYIIEHIDMGAYYYHK---------FFFNKEHQNYFGVDENLGPVA 473

  Fly  1526 VILNQRLLEQ----------------EFVT-----HSTQAPSPALRHASSNSSLQQPDQRSLHST 1569
            |.:.:..||:                |..|     .....||.| :|.:|.
Zfish   474 VSIRREKLEEGKEGPQYNYRVIFRTGELTTLRGSILEDAVPSTA-KHGTSR-------------- 523

  Fly  1570 TASFDSLPTR-------TEMPFQYCRLLFSHLGLAGWERRSRTHLLQRSEKLMRELRNVDLQKCR 1627
                 .||.:       .|:..|..|:..|                  |.|:..:|..:|.|...
Zfish   524 -----GLPLKEVLEYVVPEVNIQCLRMAIS------------------SPKVPEQLLKLDQQGLS 565

  Fly  1628 ETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFLGGLPRQ--GCGATAP 1690
            ..||:.::|..|||..:..:..|.|||...:.|:..||..:.|:..:.:...|..:  ..|..:.
Zfish   566 YQHKVGILYCQAGQSTEEEMYNNESGSPALDEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSL 630

  Fly  1691 YYATPFLEVVYHVATRMP-SDSSEAMLLKTRHLGNDEVHIVWSE-HNRDYRRDILPTEFCDVLIV 1753
            |......|:::||:|.:| :.::...||:.||:|||.|.|::.| .:..:....:.:.|..|.|:
Zfish   631 YTTYKDFELMFHVSTMLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGSLPFTPQNIRSHFQHVFII 695

  Fly  1754 VYPLRNG-----LFRVTVNRKPEVPWFGPLANESVV--SGACLATLIRATAINASRTKRAALPLY 1811
            | .:.|.     .:.:.|.|..:||.||||..:.|:  ..|.....:.|..|||..:...:
Zfish   696 V-KVHNPCTEHVCYSIAVTRSKDVPAFGPLIPKGVMFPKSAVFRDFLLAKVINAENSAHKS---- 755

  Fly  1812 QQFYEERNRSLDSVSSRYKESTTFEDFASRIYNPMPLS-------TLGTLRESNASSSAAPLASA 1869
                 |:.|::.:.:.:.......|:|.|.  .|:..|       |||..|:..    :.|..:|
Zfish   756 -----EKFRAMATRTRQEYLKDLVENFTSA--TPVDASGPKFSFITLGAKRKER----SRPRNNA 809

  Fly  1870 LLDHNRASVKGWVQA-----SIDSGPIMGIAPSASAGSTAAMEAAT-------------GMSSAS 1916
            .| ::..:|...|.|     |.|.|.::.|    |......:|.|:             |.||:|
Zfish   810 HL-YSTGAVTWSVVARDSCQSSDIGCLLAI----SREFVVLIEEASRDVVFNCYCKDVIGWSSSS 869

  Fly  1917 PRGPRKL 1923
            ..|..||
Zfish   870 TVGRVKL 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	RALGAPB_N	491..619	CDD:466561
		Rap_GAP	1648..1820	CDD:460463	46/182 (25%)
sipa1l2	XP_009304425.1	Rap_GAP	586..766	CDD:460463	47/189 (25%)
		PDZ_SIPA1-like	914..986	CDD:467227
		SPAR_C	1417..1633	CDD:463383