Protein Alignment CG5521 and gig

DIOPT Version :10

• Sequence 1: NP_001163748.1
• Gene: CG5521 / 43242
• FlyBaseID: FBgn0039466
• Length: 1964
• Species: Drosophila melanogaster
• Sequence 2: NP_524177.1
• Gene: gig / 40201
• FlyBaseID: FBgn0005198
• Length: 1847
• Species: Drosophila melanogaster
• Alignment Length: 2183
• Identity: 419/2183 - (19%)
• Similarity: 703/2183 - (32%)
• Gaps: 715/2183 - (32%)

  Fly    25 ASRLRHLRMI----LDNVELEESKCLFETNYSHVYFILYDTFI-QAEANLKQKELPFH--IVHKA 82
            |.|.|.|:.:    |.|..|:||......|.::      |..: ...|..:|..|.|:  ::|..
  Fly    41 AQRCRMLKELGDTQLHNFNLDESAITILFNLTN------DLIVPNKPAETRQIALSFYKRLIHTQ 99

  Fly    83 HREELDGSLWLL-EKILCLLPELLARRWQCHSLSRIMAKLLHLGNSPKLRREGV-RYFLLWYQTL 145
            ::     :|.:: ||...::....||....| |..::..|...|.......|.: ::.|||...:
  Fly   100 YK-----NLTIMREKFFLVIQNHEAREDLRH-LLELLDTLTDNGKDITNFEEKIGKFMLLWIPAI 158

  Fly   146 GENAPGYVHAMYADLIPGLIVPQK---------GVVGPDTEFSASDFLTHPNMKADGGMASVFHD 201
            .|   ..:...|.|::..||....         |:|....:.|.|..:....::....:..|...
  Fly   159 TE---ANLLTPYLDILVNLIKFNAAHLDKDILVGIVQNACDLSCSVTVNEIGLQCLTILEMVIGY 220

  Fly   202 NAF-SHPVQSSEVVALLPPSSSEKSAPPDPRD--------GLEVLLNSMVHTAACLRWRDNRAQK 257
            ..| |.|:  .:.:..|  ..:...||..|..        |.::..:||....:.|   ::||..
  Fly   221 TIFPSEPL--PQCITTL--CRTVNHAPYCPSSFKIMKNLLGTQLGYHSMKMMCSIL---NDRALY 278

  Fly   258 DHRAFAFLLQ-RFMDVFLPVFSPN--FDVSCSIYNPRLDLPVMRSINKKEEVMASCVVVLINWVS 319
            |.   |.||: ....:.:.:|..|  |.||...|...:....:|:::.::.::...|::.:..|
  Fly   279 DD---AHLLRGAVFHLNMNIFGSNIIFQVSPMTYATNVLTAFLRALDSRQVIVTFEVILSVRMV- 339

  Fly   320 RFTHERLLSH---RLDCTLHIEDVDQVRLHGYQQGLIVRDVLYVNRENIN--FVHEVYRQAFLLN 379
              ..:|.||.   .|.|.:              ...||.::.|....|||  .:|.:.     :|
  Fly   340 --ITKRQLSEIIWDLICDI--------------MSSIVSNIEYYEEVNINKDRLHHLQ-----IN 383

  Fly   380 FTSKPQIEAIRTAIAVYRDWMTGETPPPF-LLEPNDDPPPPSN--AGGTPRSQRLRT--PSYVGA 439
            |  ...|:.|...:...|..:.|.....: |:|...|..|.::  |....||:|:..  |.::..
  Fly   384 F--HENIDCIEKLLQQDRSQILGNVERIYDLIERVADRRPEASVLALIEYRSRRVTATRPDWLQV 446

  Fly   440 IAGSKDQLVVRAGRQN-----------VLQVFVTNAA--------NVFLVNTANLNICFPTRSRS 485
            :|    |.|.|..|.:           ::|:...|.|        .|.||:.:::::
  Fly   447 LA----QFVRRYYRMSNVNVRIKTIEALVQIMDQNRACYEEEILSRVVLVHLSHIHL-------- 499

  Fly   486 YRSTPLEEQTEICKKVLNVYRTMVMNTEMDTRTWEQLLMVLLQVTSIVLHQNQHTLPSG------ 544
              .:.::.:..:.:.:.|      ..|..||:....||.:|..:.:......:|...||
  Fly   500 --ESSVQVRVAVARALSN------FATHCDTKRCMDLLDILEALINRPFEHTRHGSSSGEGTLAE 556

  Fly   545 -----TNKSATLGGILGSAIFQTLIVTWIRAHTKVPVNVLLWEKFLNVLQSLTHREELIIEWNKT 604
                 .|..:.:..|: :|:...:.|..|:.|....::.|   |..|:|  :.|. ||..|..|.
  Fly   557 VTFGLVNNESEISDII-AAVDGLVKVFAIKLHRLPGIHAL---KIFNIL--MDHL-ELHYERPKI 614

  Fly   605 IQTLTRVFSRYTYGINLLDLPLDRVAESRAEKRRRIGSVWQGSGSNSAANGGSAASAAISQNRQR 669
            .:.::.|  ||.....||             |.|..||...|....|
  Fly   615 FEHISVV--RYKIFAWLL-------------KARANGSYHIGYPEGS------------------ 646

  Fly   670 ESLAESSSSRSEETSSQVPLPNHPRPHHQHTQSQGGTGHGTRPIPLTPMLSRSYSEGSLASAARS 734
                                                    |..:..:|.|.   .:..|...|..
  Fly   647 ----------------------------------------TEVVKFSPYLG---IDSPLLPQAHP 668

  Fly   735 SRIRRRRAA--------------------TPKPKALQPSQLAENRINPQDLRRAMSLDSLARKGD 779
            :.|..||..                    ...||.||...|.:.....:.....:.::.::....
  Fly   669 TAISIRRVCKLIVRCLEHDTDYQVFQLVIRELPKVLQNKALVQGNDIEELANTLLKINLVSNNKF 733

  Fly   780 AEETDSYQEGDNESGAGSRSPSPTASSGIEGGSIKDAQLQIDASLDDANSGSYG--SGSNSGSIS 842
            ...||.:.         :......||..|...|::..|             .||  :..||..::
  Fly   734 KRPTDEFH---------ALVLPAIASLVIYHESLQPQQ-------------HYGIITALNSRVLT 776

  Fly   843 GRRCIILGGSAEGWHPDSTSIMWKRMLGALGDVNRIPKADLHAQVFMHLLEMTQNLIKIKQNQGI 907
            |...:.:         ::.:|:...|..||  :.::|..         ||:|:    |:.....:
  Fly   777 GIASVCI---------NTMTILILEMPEAL--MRKLPDV---------LLQMS----KMSDTNAL 817

  Fly   908 STDNQNTQPMPPLVPPIGIVAPWCYGSLSLDRSFKKGKLWALQLLCSLA---IQGAVNMQQLPLF 969
            :|             |:                     |..|.||..|:   .....:|..:.:|
  Fly   818 AT-------------PV---------------------LEFLSLLIHLSKHLFANFTSMHNMYVF 848

  Fly   970 YHAL----------------HQLLTGEDRDLIYAILKHLEGPR-----LLSLLLPGHTLLLLDLV 1013
            ...|                |.::.|      :.:...||..|     :.|.:.....:|..|:|
  Fly   849 AITLPYTKPHRYDHYTVSLAHHVIAG------WFLKCKLELRRNCVNYIKSSIQSNAKMLSSDIV 907

  Fly  1014 HASAILLTSLEVSRSTP-----------------------------RAEVAALLGSLLCYPSSLL 1049
            :.:::...|....|||.                             .||:|.     .|:  ..|
  Fly   908 NLNSLNEDSSNRKRSTSLTERGSRNNANAWNDLEMRPQMNNGLRNFHAELAE-----TCF--DFL 965

  Fly  1050 TRSVLQPTPQKFELMECSD--LQDHIL-------NIVLRCARREPSAKAR---CIALSQLGQWLL 1102
            .|....|.|...:.:..::  |:|.:.       |:|.......|||.||   |...:|||:...
  Fly   966 ARHTYSPCPSMPKRLPAAEFLLKDGVSQTWLVGNNLVTITTSGCPSAPARSGLCERCAQLGKAPS 1030

  Fly  1103 M-----RLSQPLPASNSGRANLFQQAVPHHKDVHPKA-------SSVYNPRIKEVLQVLLQALQF 1155
            :     .||...|..:..|...:.:....|...:..|       ||..|.         ..|...
  Fly  1031 ISLNSKSLSDAAPPLSPERERRYTKVSLQHSSGNESAGSTELTSSSSSNS---------AAAGGH 1086

  Fly  1156 KHHTIAIVAVDSLKLCAERGRQLAAIERVPQLIITAICK-------------ALEIQSVTKPKDS 1207
            .|..|:..:..||...:.||..       |:.:.:|:.:             :|...||:....|
  Fly  1087 PHRQISNSSTASLDALSRRGSN-------PEALGSALGEGAHTGSNTSLLGNSLSQSSVSMSPSS 1144

  Fly  1208 DKVVLTSLML--CLG-------------EFCMAIPAPI------MLTPFNEQGDTLVLQVLRVLL 1251
            ..||...:.:  |.|             .:...|..||      ...|||        .|:.:.|
  Fly  1145 GSVVQQPVCVRACTGWAEVLVRRPTGNVSWITRIQNPITNDCFGQELPFN--------NVVSLFL 1201

  Fly  1252 QVASG----------APRHERVKLTADDDFDMHIAHDDLQGDGRLPEATYQTSETIQKCITAIKL 1306
            ..|.|          ||.|    ..||.:.:              |||....:...|......::
  Fly  1202 PTAHGGVFGPDNTIQAPPH----TLADPEPE--------------PEAEVNAATAPQASALRSRM 1248

  Fly  1307 CAKAVSMHLVTHIGHFPMGIGASRLSSMVEEQDDI----GNAAYGGQVETRRDSVELPSVVSAQN 1367
            .|||.::                      :.|::|    ||....|   ....|...||...
  Fly  1249 VAKARAL----------------------QRQEEIHSVGGNGNGNG---NGNGSGNAPSTGG--- 1285

  Fly  1368 MQLFMLNSGLVASFIELPTLKLPG---------GGITAG------LVTADKQVRVL--MRDLNG- 1414
                       |:.|.:|.:...|         |.::.|      |...|.|.|..  :|.:|.
  Fly  1286 -----------AAAIPIPRVPASGKRGKEAALCGSVSDGEADDDSLAFEDAQSRARNPVRRVNSS 1339

  Fly  1415 ---KACWDASILYSEPRN-AEEPPKTTPKIQHSQPLDSMATSMVTHT------------------ 1457
               .:.|..|.|.::|.. ::||.|||  ....|.|.::....|.::
  Fly  1340 PEMSSSWRQSFLTNKPTPLSQEPVKTT--ADEPQSLLTLKKKTVQYSTKDMRVSCEAIPEEIAGS 1402

  Fly  1458 --PSPRHTLRHRP-AGVLPLAKDMAPDLDQLDDMLAYIGHTSPECVAPTVSQLNAPTASPLSGNQ 1519
              ||....|..:| :|.||      |.....||:.:::...|......:..:|..|   |||..|
  Fly  1403 TPPSQAAALALQPESGTLP------PKQHSADDVSSHVAGGSNLQAGGSTLKLGKP---PLSPGQ 1458

  Fly  1520 EAQAISVILNQRLLEQEFVTH--STQAPSP-ALRHASS--------------------------- 1554
            ..          ||....||.  .|..|.| ||..:||
  Fly  1459 PP----------LLGTGRVTSFGGTSVPQPGALAKSSSSGSNGTNVGVITSDYDNGNNGNGDMMR 1513

  Fly  1555 -------------NSSLQQPDQRSLHSTTASFDSLPTRTEM--PFQYCRLLFS-HLGL------A 1597
                         |.:.:.|...|..:..|:...:.|:..|  .|.:.:|..: .||:      .
  Fly  1514 GRSKTISVVREVNNGNTRPPPASSFRNFGAAKPPINTKLCMNPSFIFMQLYTTGQLGVTDEPLKV 1578

  Fly  1598 GWERRSRTHLLQRSEKLMRELRNVDLQKCRETHKMAVIYVAAGQ-EDKGSILRNTSGSSTYEMFV 1661
            |.|..|...|             :||....||||:.|:||..|| .::..||||:.||:.|..|:
  Fly  1579 GPENSSAVSL-------------IDLVPPFETHKIGVLYVGQGQCNNEVEILRNSHGSARYVEFL 1630

  Fly  1662 SALGWEIDL---ETHNGFLGGLPRQGC-GATAPYYATPFLEVVYHVATRMPSDSSEAMLL--KTR 1720
            ..:|..:.|   |.:|.|: .|.|.|. |..|..:....|:|.:||||.||::..:....  |..
  Fly  1631 RNIGTLVSLKEAEQNNLFI-MLDRNGADGKFAYIWKDDILQVTFHVATLMPTNLQDDPNCNEKKS 1694

  Fly  1721 HLGNDEVHIVWSEHNRDYRRDILPTEFCDVLIVVYPLRNGLFRVTVNRKPEVPWFGPLANESVVS 1785
            |:|||.|.|:::|...:|..:.:..:|....::|.||.....||.|..:.|:..|...|...:||
  Fly  1695 HIGNDFVKIIYNESGEEYNLNTISGQFNYACVIVEPLDLNSNRVYVKARSEISKFVCHAEYRIVS 1759

  Fly  1786 GACLATLIRATAINASRTKRAALPLYQQFYE---------ERNRSLDSVSSRYKESTTFEDFASR 1841
            ......|.|..|::|:    .|..:||...:         ||.|.|..:.|:..|.
  Fly  1760 DRSAPLLARQMALHAN----LASLVYQSVQKKHPYASNWLERLRKLKRLRSKLIEG--------- 1811

  Fly  1842 IYNPMPLSTLGTLRESNASSSAAPL-ASAL---LDHNR 1875
                     |.:.::|.::||...: |||:   :|..|
  Fly  1812 ---------LNSQQKSGSASSGIGINASAIGSDMDDQR 1840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	RALGAPB_N	491..619	CDD:466561	28/138 (20%)
		Rap_GAP	1648..1820	CDD:460463	55/186 (30%)
gig	NP_524177.1	DUF3384	40..421	CDD:463376	86/428 (20%)
		Tuberin	566..882	CDD:460965	71/484 (15%)
		PRK12727	<1219..>1418	CDD:237182	46/257 (18%)
		Rap_GAP	1617..1802	CDD:460463	56/189 (30%)