Protein Alignment CG5521 and rsh

DIOPT Version :10

• Sequence 1: NP_001163748.1
• Gene: CG5521 / 43242
• FlyBaseID: FBgn0039466
• Length: 1964
• Species: Drosophila melanogaster
• Sequence 2: XP_061500025.1
• Gene: rsh / 3290563
• VectorBaseID: AGAMI1_011524
• Length: 1556
• Species: Anopheles gambiae
• Alignment Length: 1505
• Identity: 266/1505 - (17%)
• Similarity: 450/1505 - (29%)
• Gaps: 492/1505 - (32%)

  Fly   623 DLPLDRVAESRAEKRRRIGSVWQGSGSNSAANGGSAASAAISQNRQRESLAE----------SSS 677
            ||..::|.||..  |:|:|.....:...|.|:..|.:....:|.|:|.|||:          ..|
Mosquito    38 DLVREQVEESTI--RQRLGGRRDSAAQISGASPPSTSPPPGAQRRRRSSLAQLTDILREWSGGGS 100

  Fly   678 SRSE------ETSSQV--PLPNHPRPHHQHTQSQGGTGHGTRPIPLTPMLSRSYSEGSLASAARS 734
            .|.:      ||.:.:  .||.:.....:...||..:||..   ||     |...|.|..|..:|
Mosquito   101 KRQKAPLNRRETLADLARSLPWNKATTGESYNSQNNSGHAP---PL-----RKRRESSADSGVKS 157

  Fly   735 SRIRRRRAATPKPKALQPSQLAENRINPQDLRRAMSLDSLARKGDAEETDSYQEGDNESGAGSRS 799
            ...||                 ::.::  |.|:....:....|....|.:..:|.:.|
Mosquito   158 WSYRR-----------------DSHVS--DFRKEREWEREREKERERERERERERERE------- 196

  Fly   800 PSPTASSGIEGGSIKDAQLQIDASLDDANSGSYGSGSNSGSISGRRCIILGGSAEGWHPDSTSIM 864
                          :|....|.::.:..|.....|..:|...|.||...:||:|
Mosquito   197 --------------RDRDDYIYSTDNYRNGSRRNSNDSSRDRSSRRDSTIGGTA----------- 236

  Fly   865 WKRMLGALGDVNRIPKADLHAQVFMHLLEMTQNLIKIKQNQGISTDNQNTQPMPPLVPPIGIVAP 929
                                                             |.|.||  |.:
Mosquito   237 -------------------------------------------------TPPPPP--PKV----- 245

  Fly   930 WCYGSLSLDRSFKKGKLWALQLLCSLAIQGAVN--MQQLPLFYHALHQLLTGEDRDLIYAILKHL 992
                 :...|..|.          ||.:....|  .:|.|      ....|..|...::..:.|:
Mosquito   246 -----VGTQRKRKD----------SLVVAEMPNFRQEQRP------STSSTASDSGPLFVAVAHV 289

  Fly   993 EGPRLLSLLLPGHTLLLLDLVHASAILLTSLEVSRSTPRAEVAALLGSLLCYPSSLLTRSVLQPT 1057
            :.   ....||..|           |:.:|:....::|.|:......:..|  .:.:||...:.:
Mosquito   290 DS---ACQALPPPT-----------IITSSVTPPATSPTAQKGRRDSTTQC--GTKMTRRDSRVS 338

  Fly  1058 PQKFELMECSDLQDHILNIVLRCARREPSAKARCIALSQLGQWLLMRLSQPL------------- 1109
            |::.:.:  |.||           |:..:....|:   ..|.| ..|.|||.
Mosquito   339 PERAQRL--SKLQ-----------RQATAYDESCL---PPGGW-SRRSSQPALSPDGEGPERQAR 386

  Fly  1110 -----PASNS-GRANLFQQAVP---HHKDVHPK---------ASSVYNPRIKEVLQVLLQALQFK 1156
                 |.|.| ||.:......|   |.::..|:         :|:...||
Mosquito   387 RDSLSPDSASRGRRDSRSHLSPDRSHEREGSPRRSRRLRRQSSSAARQPR--------------- 436

  Fly  1157 HHTIAIVAVDSLKLCAERGRQLAAIERVPQLIITAICKALEIQSVTKPKDSDKVVLTSLMLCLGE 1221
                   :.||...|:.|.....|....|            .:|..:|....:.....:::..|
Mosquito   437 -------SPDSSSCCSSRDASPCARPPPP------------TESTARPSIRRQSTTEEILIARG- 481

  Fly  1222 FCMAIPAPIMLTPFNEQGDTLVLQVLRVLLQVASGAPRHERVKLTADDDFDMHIAHDDLQG---D 1283
                         |..|..|  .:::|.         |:.|.:.:..||...:....|...   |
Mosquito   482 -------------FRRQSTT--EEMIRC---------RNFRRQSSQSDDTSRYRGRRDSSAQIID 522

  Fly  1284 GRL-------------------------PEATYQTSETIQKCITAIKLC-----------AKAVS 1312
            |.:                         |...|:.:...::|:.. ..|           |:...
Mosquito   523 GTIGTMTVETTSKLRRLHGSSQQSHESEPSPLYENNHYHEECLRC-NSCGLNLTGPNQKRARRFK 586

  Fly  1313 MHLVTHIGHFPMGIGASRLSSMVEEQDDIGNAAYGGQVETRRDSVEL-----PSVVSAQNMQLFM 1372
            ..::..: || ..:.....|..:::.......:.|..|..|:.|..|     |...|.:..:.:.
Mosquito   587 NQILCDL-HF-ADVALMECSDFMQQLRSFKPQSLGCAVARRKSSTTLIFPLPPQACSDEFCEDYP 649

  Fly  1373 LNSGLVASFIELPTLKLPGGGITAGLVTADKQVRVLMRDLNGKACWDASILYSEPRNAEEPPKTT 1437
            .|.        :||   ||..|...        |..:...|....||.|  .||...|.......
Mosquito   650 HNL--------IPT---PGYWIECS--------RQKIAFPNQHTIWDDS--ESEHEEAARGITVE 693

  Fly  1438 PKIQ------HSQPLDSMATSMVTHTPSPRHTLRHRPAGVLPLAKDMAPDLDQLDDML---AYIG 1493
            |:::      :....||      .:.||.:...|.:.|......:....:|..::...   .:.|
Mosquito   694 PQLERNCSDLYEDDEDS------DNVPSSQRFRRKKTAIEEQWEQQQGFELTSVEQETYEKYFYG 752

  Fly  1494 ------HTSPECVAPTVSQLNAPTASPLSGNQE----AQAISVILNQRLLEQEFVTHSTQAPSPA 1548
                  .|:.|.:.|.:..:...|   ::|..:    .:|||..:: .|:....|..........
Mosquito   753 TEHWNYFTNDEDLGPVILSIKQET---INGRDQFRILVRAISYTVH-GLIPASCVFADRYNREEV 813

  Fly  1549 LRHASSNSSLQQPDQRSLHSTTASFDSLPTRTEMPFQYCRLLFSHLGLAGWERRSRTHLLQRSEK 1613
            :|......:|..|         .:...||...|
Mosquito   814 VRSLGKEVNLNPP---------LTLGQLPDTPE-------------------------------- 837

  Fly  1614 LMRELRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFLG 1678
               ||..:|....:...|:.||||..||..:..||.|...|..:|.|:..||.::.|...:.:.|
Mosquito   838 ---ELLKLDQVFIKSELKVGVIYVKEGQYTEEQILDNNENSPLFEEFLQLLGDKVRLRGFDKYKG 899

  Fly  1679 GLP--RQGCGATAPYYATPFLEVVYHVATRMPSDSSEAM-LLKTRHLGNDEVHIVWSE-HNRDYR 1739
            ||.  ....|..:.|.....:|:::||:|::|.:..:.. |.:.||:|||.|.:|:.| .|..:.
Mosquito   900 GLDTVHDLTGLYSVYTNWRSIEIMFHVSTQLPYEKHDPQKLQRKRHIGNDIVCVVFLEADNTAFS 964

  Fly  1740 RDILPTEFCDVLIVV--------YPLRNGLFRVTVNRKPEVPWFGPLANESVV--SGACLATLIR 1794
            ...:.:.|....|:|        .|.|   :.|:|..:.||..:.|...|..|  .|......:.
Mosquito   965 PACIKSHFLHTFILVRVSARIKRKPTR---YEVSVVTRDEVGAYKPYLWEQSVFEKGPMFREWLL 1026

  Fly  1795 ATAINASRTKRAALPLYQQFYEERNRSLDSVSSRYKESTTFEDFASRIYN-------PMPLSTLG 1852
            ...:|..|...:| |.:.:. :||.|           |...||..:.:.|       |.|... |
Mosquito  1027 TKIVNGERASYSA-PKFARM-QERTR-----------SQMLEDIVANLANHAETGQIPKPYRR-G 1077

  Fly  1853 TLRE---------------------SNASSSAAPLASALLDHNRASVKGWVQASIDSGPIMGIAP 1896
            :.|.                     .|.:....| :|.|||..|...:.:.|.:.|...:. :..
Mosquito  1078 SWRPIDILMHTDSHILSHTDSGFLIRNCTRHMRP-SSPLLDSVRDQFEDYDQLAKDFTRVF-LNS 1140

  Fly  1897 SASAGSTAAMEAATGMSSASPRGPRKLGAPFKSVTKKHSLQHIAVGGGAGAGGDTPP-------E 1954
            ..|....|.:.....:...|.:..|.:|.......:....|.:..|...|.|....|       .
Mosquito  1141 EPSCLQNAQLFDVVFLVGQSKQRARFIGVRAILGVRSRVFQEMLYGIQTGFGSPQVPVAELLARP 1205

  Fly  1955 SPTL--PQRR 1962
            :|||  ||.:
Mosquito  1206 APTLLSPQNQ 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	RALGAPB_N	491..619	CDD:466561
		Rap_GAP	1648..1820	CDD:460463	47/185 (25%)
rsh	XP_061500025.1	None