|
Fly 1 MFTKKSHADVKKSTAKLQDSKKDSASRLRHLRMI----------------LDNVELEESKCLFET 49
||:::||.||||||.|:.|.|||..:||:|||.: ||||:..:.|..|||
Rat 1 MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLGTHDPQYRGRVRAGHLDNVDASDLKQFFET 65
Fly 50 NYSHVYFILYDTFIQAEANLKQKELPFHIVHKAHREELDGSLWLLEKILCLLPELLARRWQCHSL 114
|||.:|||.|:.||..|.:||.|. .:|:.|||||..|:|.||||..|||.:..||...|:
Rat 66 NYSQIYFIFYENFITLENSLKLKG-----NNKSQREELDSILFLFEKILQFLPERIFFRWHYQSI 125
Fly 115 SRIMAKLLHLGNSPKLRREGVRYFLLWYQTLGENAPGYVHAMYADLIPGL--IVPQKGVVGPDTE 177
...:.||||.|||.|:|.||:|.||||.|.|..|.......::|.|:||. ::..:|....:|
Rat 126 GSTLKKLLHTGNSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVLSSRGPCTLET- 189
Fly 178 FSASDFLTHPNMKADGGMASVFHDNAFSHPVQSSEVVALLPPSSSEKSAPPDPRDGLEVLLNSMV 242
|.:|: .:.....:...|:..|||..|.||.|.......|::||..||
Rat 190 ------LINPS------------PSVVDAKIYPEEITPLLPAVSGEKIAEDQTCFFLQILLKYMV 236
Fly 243 HTAACLRWRDNRAQKDHRAFAFLLQRFMDVFLPVFSPNFDVSCSIYNPRLDLPVMR------SIN 301
..||.|.|: |:..:| ..|.||...|...:||...|:|....:||.|.|::|.:| ::.
Rat 237 IQAASLEWK-NKENQD-TGFKFLFTLFRKYYLPHLFPSFTKLTNIYKPVLEIPHLRPKPLYVTVT 299
Fly 302 KKEEVMAS-------CVVVLINWVSRFTHERLLSHRLDCTLHIEDV------------------- 340
:..|.:.| ..||.|.|:..|..|:........|.:..||
Rat 300 RDNETIYSTKIPYMAARVVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAIQEKVPE 364
Fly 341 -------DQVRLHGYQQGL----------------------IVRDVLYVNRENINFVHEVYRQAF 376
:|.:.|.....| :|:.:|...|..:|||:||:||||
Rat 365 LDGAGATEQDKSHSNSSTLSDRRLSNSSLCSIEEEHRTVYEMVQRILLSTRGYVNFVNEVFRQAF 429
Fly 377 LLNFTSKPQIEAIRTAIAVYRDWMTGETPPPFLLEPN-----------------DDPPPPSNAGG 424
|| ...:|...|..:.|||.|:. :..|.|:.||: |.....|.:.|
Rat 430 LL---PSCEISITRKVVQVYRKWIL-QNKPVFMEEPDKKDVAEEDADKLGLSETDSKEVSSESSG 490
Fly 425 TPRSQRL-RTPSYVGAIA----GSKDQLVVRAGRQNVLQVFVTNAANVFLVNTANLNICFPTRSR 484
..||... ||.|:..|:: ..:|...|:||.|.:||||:|||||||| |..|.
Rat 491 HKRSSSWGRTYSFTSAMSRGCVTEEDNTNVKAGAQAMLQVFLTNAANVFL-----LEPCV----- 545
Fly 485 SYRSTP--LEEQTEICKKVLNVYRTMVMNTEMDTRTWEQLLMVLLQVTSIVLHQNQHTLPSGTNK 547
..| |.||.:.||.||.::|.|:|...|:.:||||:|.:||::|..|:.:.:..|.. .:.
Rat 546 ---EVPMLLREQVDACKAVLIIFRRMIMELTMNQKTWEQMLQILLRITEAVMQKPKDKLVQ-DSF 606
Fly 548 SATLGGILGSAIFQTLIVTWIRAHTKVPVNVLLWEKFLNVLQSLTHREELIIEWNKTIQTLTRVF 612
:.:|.|:| |:||||.||||:..|.::..||:.||.||.|||..||||.||:..:.:||.|.
Rat 607 ARSLAGLL----FRTLIVAWIRANLCVYISRELWDDFLRVLSSLTEWEELITEWSNIMDSLTAVL 667
Fly 613 SRYTYGINLLDLPLDRVAESRAEKRRRIGSV----------------WQG-----------SGSN 650
:|..||:.:.:||||:::|.:.:|:|..|.| |:. |.:.
Rat 668 ARTVYGVEMTNLPLDKLSEQKEKKQRGKGCVLEPQKGTAVGRSFSLSWRSHPDVTEPMRFRSATT 732
Fly 651 SAANGGSAASAAISQNRQRESLAESSS-------SRSEETSSQVPLPNH------------PRPH 696
|.|.|...|...: ||:.:...|.| |.:...:..|||..| |..|
Rat 733 SGAPGVEKARNTV---RQKATAKRSQSISNCVHLSEALPATKSVPLLLHTVSALLPGLSYSPCSH 794
Fly 697 H-------QHTQSQGGTG-----HGTRPIPLTPMLS----RSYSEGS-------------LASAA 732
. |..:|..... .|.:|:|.:...| |.||:.| :||..
Rat 795 RLSEVEEFQQAESTAAADCDYLVVGQQPVPRSSSTSDITERLYSDSSQGYSPMLPHPAFYMASGD 859
Fly 733 RSSRIRRRRAATPKPKAL----QPSQLAENRIN-----PQDLRRAM--------SLDSLARKGDA 780
.:| ...|.|..|..| .|.|..||..| |:.::.:. .:..|.|:..:
Rat 860 LNS---GPHACTTGPLPLSHLPSPGQKVENSQNLSSSEPKSVQESKGHVTHEHEGVTILVRRSSS 921
Fly 781 -EETDSYQEGDNESG-AGSRSPSPTASSGIEGGSIKDAQLQI----------------DASLD-D 826
.|.|..:|.....| ...|..|.:..|.:..|...:|:|.: ||..| |
Rat 922 PAELDLKEESQQTHGRCRERQKSESTGSDMAVGYSNEAELPVSPWQTCEEDPELSTPTDAVADSD 986
Fly 827 ANSGSYGSGSNSGSIS-GRRC------IILGGSAEGWHPDSTSIMWKRMLGALGDVNRIPKADLH 884
|......|.:::.::: .|.| ||.||:..||||||.:::|:|:||.|||||.|....:|
Rat 987 ARHWLQLSPTDASNLTESRECLADDCSIIAGGNLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIH 1051
Fly 885 AQVFMHLLEMTQNLIKIKQNQGISTDNQNTQPMPPLVPPIGIVAPWCYGSLSLDRSFKKGKLWAL 949
|:||.:|.|:...|.||:.|..||.|||::...|.|:||:.:.|.|.:.:.:|...:|:|||.|.
Rat 1052 AKVFSYLYELWYKLAKIRDNLAISLDNQSSPSPPLLIPPLRMFASWLFKATTLPNEYKEGKLQAY 1116
Fly 950 QLLCSLAIQG---AVNMQQLPLFYHALHQLLTGEDRDLIYAILKHLEGPRLLSLLLPGHTLLLLD 1011
:|:|::..:. ..|...|..||..:|..||.||:|::..|:|:. .||..||.|||.::|:.|
Rat 1117 KLICAMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDVLNTIIKNC-SPRFFSLGLPGFSMLVGD 1180
Fly 1012 LVHASA-ILLTSLEVSRSTPRAEVAALLGSLLCYPSSLLTRSVLQPTPQKFELME-CSDLQDHIL 1074
.:.|:| :|.|.: .:.||:|...|||||:|:|::.....:||..|:..:::. ..|::.:::
Rat 1181 FITAAARVLSTDM---LAAPRSEALTLLGSLVCFPNTYQEIPLLQSVPEVSDVVTGAEDVKHYLI 1242
Fly 1075 NIVLRCARREPSAKARCIALSQLGQWLLMRLSQPLPASNSGRANLFQQAVPHHKDVHPKASSVYN 1139
||:|:.|..||:..|||||:..||.|:...|:| ...:
Rat 1243 NILLKNATEEPNECARCIAICSLGVWICEELAQ----------------------------CASH 1279
Fly 1140 PRIKEVLQVLLQALQFKHHTIAIVAVDSLKLCAERGRQLAAIE-----RVPQLIITAICKAL--- 1196
|::|:.:.|:...|:|.:..:|.||.|.|:|......:|...| ::.::::..|...|
Rat 1280 PQVKDAINVIGVTLKFPNKIVAQVACDVLQLLVSYWEKLQMFETALPRKMAEILVATIAFLLPSA 1344
Fly 1197 EIQSVTKPKDSDKVVLTSLMLCLGEFCMAIPAPIMLTPFNEQGDTLVLQ------------VLRV 1249
|..|| ::||..:.||:|||.::|||:|...:|.|.: |.|:: :.||
Rat 1345 EYSSV----ETDKKFIVSLLLCLLDWCMALPVSALLHPVS----TAVIEELHPSRAPLLDYIYRV 1401
Fly 1250 LLQVASGAPRHERVKLTADDDFDMHIAHDDLQG---DGRLPEATYQTSETIQ------------- 1298
|.....|:..: |....:.:.:| ||.. |..||.|..:.||.:|
Rat 1402 LHCCVCGSSTY-----TQQSHYTLTLA--DLSSTDYDPFLPLANVRNSEPVQYHSSADLGNLLTV 1459
Fly 1299 ------KCITAIKLCAKAVSMHLVTHIGHFPMGIGASRLSSMVEEQDDIGNAAYGGQVETRRDSV 1357
:.:..|.|.|:.|..|||.|:||:|:..|.:.|.|:|.|..| ||...| .
Rat 1460 EEEKKRRSVELIPLTARMVMAHLVNHLGHYPLSGGPAVLHSLVSENHD--NAHVEG--------T 1514
Fly 1358 ELPS-VVSAQNMQLFMLNSGLVASFIELPTLKLPGGGITAGLVTADKQVRVLMRDLNGKACWDAS 1421
||.| |..:.|:|||:.|...:.|:::.|. :.|.||.:.|.:: .|||::||::||..||..
Rat 1515 ELSSEVFRSPNLQLFVFNDSTLISYLQTPA-EGPAGGTSGGSLS---DVRVIVRDISGKYSWDGK 1575
Fly 1422 ILYSEPRNAEEPPKTTPKIQHSQPLDSMATSMVTHTPSPRHTLRHRPAGVLPLAKDMAPDLDQLD 1486
:||........|....|..|.| ....||..|:..|.|...|. |.||
Rat 1576 VLYGPLEGRLAPSGRNPSFQIS--------GWHHHTCGPQSNLFHGEEGD-----------DVLD 1621
Fly 1487 DMLAYIGHTSPECVAPTVSQLN----APTASPLSGNQEAQAISVILNQRLLEQEFVTHSTQAPSP 1547
.:|..||||||||:.| |||| :||.|.::.:||.:.|.|||.|...|.|:|
Rat 1622 KLLENIGHTSPECLLP--SQLNLNEPSPTPSAMNCDQEKEIIEVILRQSTQEDEYV--------- 1675
Fly 1548 ALRHASSNSSLQQPDQRSLHSTTASFDSLPTRTEMPFQYCRLLFSHLGLAGWERRSRTHLLQRSE 1612
:...|||::: .|:.....|.....||.:||||...||:..|:||...|||:::.
Rat 1676 --QRCHSNSAVK---------VTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRKNFHLLKKNS 1729
Fly 1613 KLMRELRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFL 1677
||:|||:|:|.::||||||:||.|:|.|||||.|||.|..||..||.||:.||||:||.||.||:
Rat 1730 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILANERGSQAYEDFVAGLGWEVDLSTHCGFM 1794
Fly 1678 GGLPRQG-CGATAPYYATPFLEVVYHVATRMPSDSSEAMLLKTRHLGNDEVHIVWSEHNRDYRRD 1741
|||.|.| .|.|||||||..:||::||:|||||||.:::..|.|||||||||||||||:|||||.
Rat 1795 GGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHSRDYRRG 1859
Fly 1742 ILPTEFCDVLIVVYPLRNGLFRVTVNRKPEVPWFGPLANESVVSGACLATLIRATAINASRTKRA 1806
|:||.|.||.|::||::|.:|.:|:.:|||||:||||.:.::|||..|.:||.||.|||||..:.
Rat 1860 IIPTAFGDVSIIIYPMKNHMFFITITKKPEVPFFGPLFDGAIVSGKLLPSLICATCINASRAVKC 1924
Fly 1807 ALPLYQQFYEERNRSLDSVSSRYKESTTFEDFASRIYNPMPLSTL-GT 1853
.:||||.|||||...|:::...::|..||||||:::::|.|..:| ||
Rat 1925 LIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQVFSPSPSYSLSGT 1972
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