DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5521 and SIPA1L1

DIOPT Version :9

Sequence 1:NP_001163748.1 Gene:CG5521 / 43242 FlyBaseID:FBgn0039466 Length:1964 Species:Drosophila melanogaster
Sequence 2:NP_001341214.1 Gene:SIPA1L1 / 26037 HGNCID:20284 Length:1804 Species:Homo sapiens


Alignment Length:326 Identity:79/326 - (24%)
Similarity:132/326 - (40%) Gaps:66/326 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  1567 HSTTASFDSLPTR-------TEMPFQYCRLLFSHLGLAGWERRSRTHLLQRSEKLMRELRNVDLQ 1624
            |||..   .||.:       .|:..|..||.|:                  :.|:..:|..:|.|
Human   562 HSTAR---GLPLKEVLEHVVPELNVQCLRLAFN------------------TPKVTEQLMKLDEQ 605

  Fly  1625 KCRETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFLGGLPRQ--GCGA 1687
            ......|:.::|..|||..:..:..|.|....:|.|:..||..:.|:....:...|..:  ..|.
Human   606 GLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGT 670

  Fly  1688 TAPYYATPFLEVVYHVATRMP-SDSSEAMLLKTRHLGNDEVHIVWSEHN-RDYRRDILPTEFCDV 1750
            .:.|......|:::||:|.:| :.:::..||:.||:|||.|.||:.|.. :.:....:.:.|..|
Human   671 HSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHV 735

  Fly  1751 LIVV---YPLRNGL-FRVTVNRKPEVPWFGP-------LANESVVSGACLATLIRA-TAINASRT 1803
            .::|   .|..:.: :.|.|.|..:||.|||       ....:|.....||.:|.| .|.:.|..
Human   736 FVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEK 800

  Fly  1804 KRAALPLYQQFY-------EERNRSLD--------SVSSRYKESTTFEDFASRIYNPMPLSTLGT 1853
            .||.....:|.|       ...|..:|        |::|:.||.       |:.|....||::|.
Human   801 FRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEK-------SKPYPGAELSSMGA 858

  Fly  1854 L 1854
            :
Human   859 I 859

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5521NP_001163748.1 Rap_GAP 1648..1820 CDD:280332 49/194 (25%)
SIPA1L1NP_001341214.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..157
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 277..297
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..401
Rap_GAP 629..809 CDD:307998 47/179 (26%)
PDZ_signaling 953..1023 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1128
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1144..1207
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1268..1306
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1366
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1379..1475
SPAR_C 1504..1749 CDD:314711
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1505..1536
ZapB 1737..1792 CDD:310531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3686
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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