DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5521 and RALGAPA1

DIOPT Version :9

Sequence 1:NP_001163748.1 Gene:CG5521 / 43242 FlyBaseID:FBgn0039466 Length:1964 Species:Drosophila melanogaster
Sequence 2:XP_006720161.1 Gene:RALGAPA1 / 253959 HGNCID:17770 Length:2590 Species:Homo sapiens


Alignment Length:2750 Identity:758/2750 - (27%)
Similarity:1097/2750 - (39%) Gaps:1009/2750 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFTKKSHADVKKSTAKLQDSKKDSASRLRHLRMILDNVELEESKCLFETNYSHVYFILYDTFIQA 65
            ||:||.|.||||||.|:.|:|||:.:||:|||::::|.|..:.|..|:.::||:|::.::.|:..
Human     1 MFSKKPHGDVKKSTQKVLDTKKDALTRLKHLRIVIENAESIDLKQFFDQHFSHIYYVFFENFVTI 65

  Fly    66 EANLKQKELPFHIVHKAHREELDGSLWLLEKILCLLPELLARRWQCHSLSRIMAKLLHLGNSPKL 130
            ||:||||.      ||:.|||||..|::.||||.||||.:.:|||.||:..|:.||||.|||.|:
Human    66 EASLKQKG------HKSQREELDAILFIFEKILQLLPERIHQRWQFHSIGLILKKLLHTGNSLKI 124

  Fly   131 RREGVRYFLLWYQTLGENAPGYVHAMYADLIPGLIVPQKGVVGPDTEFSASDFLTHPNMKADGGM 195
            ||||||.||||.|.|..|.......|::.||||...|| ...||.|    .|.|.:|.:      
Human   125 RREGVRLFLLWLQALQNNCSKEQLWMFSCLIPGFSAPQ-SEHGPRT----LDNLINPPL------ 178

  Fly   196 ASVFHDNAFSHPVQSSEVVALLPPSSSEKSAPPDPRDGLEVLLNSMVHTAACLRWRDNRAQKDHR 260
                  |.....|...|:..|:||.|.:|.........||.||..:|.....|.|::...|:  |
Human   179 ------NLQETQVTIEEITPLVPPQSGDKGQEDLTSYFLEALLKYIVIQVKSLEWKNKENQE--R 235

  Fly   261 AFAFLLQRFMDVFLPVFSPNFDVSCSIYNPRLDLPVMRS-----INKKE-----------EVMAS 309
            .|:||...|...:||...||.....|:|:|.||:|.||.     :.||:           |....
Human   236 GFSFLFSHFKKYYLPYIFPNICKENSLYHPILDIPQMRPKPHYVVIKKDAETNEAIYCTKEPFIK 300

  Fly   310 CVVVLINWVSRF-----------------------------------------------THERLL 327
            ..|::|.|:..|                                               |.|...
Human   301 ARVIVIRWLVSFWLEPKPHTGPHIPGMEGEVLPKNIQRAAASLVSREESKNDNADKTDRTTEPEQ 365

  Fly   328 SHRLDCTL----------------HIEDVDQVRLHGYQQGLIVRDVLYVNRENINFVHEVYRQAF 376
            ||....||                |:.|::           |||.|....|.|:|||.|::||||
Human   366 SHSNTSTLTEREPSSSSLCSIDEEHLTDIE-----------IVRRVFSSKRSNVNFVTEIFRQAF 419

  Fly   377 LLNFTSKPQIEAIRTAIAVYRDWMTGETPPPFLLEPND------DPPPPSNA------------- 422
            ||...   :..|:|..:.||::|:..|..|.|:.||.:      |.|...|.             
Human   420 LLPIC---EAAAMRKVVKVYQEWIQQEEKPLFMQEPEEIVITSSDLPCIENVTDHDISMEEGEKR 481

  Fly   423 ---GGTPRSQRLRTP------SYVGAIAGSKDQLV---VRAGRQNVLQVFVTNAANVFLVNTAN- 474
               .||..:..:|..      ||.||:..:.::..   :|||.|.|||||:.|::|:||:..|| 
Human   482 EEENGTNTADHVRNSSWAKNGSYQGALHNASEEATEQNIRAGTQAVLQVFIINSSNIFLLEPANE 546

  Fly   475 -LNICFPTRSRSYRSTPLEEQTEICKKVLNVYRTMVMNTEMDTRTWEQLLMVLLQVTSIVLHQ-N 537
             .|:             |:|.|::||::||:||.||:...||.:||||:|:|||:||..||.. :
Human   547 IKNL-------------LDEHTDMCKRILNIYRYMVVQVSMDKKTWEQMLLVLLRVTESVLKMPS 598

  Fly   538 QHTLPSGTNKSATLGGILGSAIFQTLIVTWIRAHTKVPVNVLLWEKFLNVLQSLTHREELIIEWN 602
            |..|.....|:.||.|.|...:||||||.||:|:..|.::..||:..|:||.|||:.|||..||:
Human   599 QAFLQFQGKKNMTLAGRLAGPLFQTLIVAWIKANLNVYISRELWDDLLSVLSSLTYWEELATEWS 663

  Fly   603 KTIQTLTRVFSRYTYGINLLDLPLDRVAESRAEKRRRIG--------SV-------W-------- 644
            .|::|||:|.:|..|.::|.|||||:::|.:.:|.:..|        ||       |        
Human   664 LTMETLTKVLARNLYSLDLSDLPLDKLSEQKQKKHKGKGVGHEFQKVSVDKSFSRGWSRDQPGQA 728

  Fly   645 ---QGSGSNSAANGGSAASAAISQN----RQRESLAESS-------------------------- 676
               |.|.:.:.:.|...|.:.:.|.    |.| |:.|.:                          
Human   729 PMRQRSATTTGSPGTEKARSIVRQKTVAMRSR-SIGECALPSAYIRSAKSAPVLIHTSKPFLPDI 792

  Fly   677 --------------------------SSRSEETSSQV--------PLP----------------- 690
                                      .|:||||.::|        |||                 
Human   793 VLTPLSDELSDIDDAQILPRSTRVRHFSQSEETGNEVFGALNEEQPLPRSSSTSDILEPFTVERA 857

  Fly   691 ----------------------------------------------------------------- 690
                                                                             
Human   858 KGAVPVIDSSSRHAPSLQSSTEASSITRSTESHITDTHSRESSLEVGDSIYDHLCHLIGPVELAD 922

  Fly   691 ------------------------------NHPRPH----------------------------H 697
                                          ||.:..                            .
Human   923 SAFEQIQYIDLEGDDDLLSTLKEYFKENQENHSKNETGKDPASQEVTIAVNRGERLSLDKLECTD 987

  Fly   698 QHTQSQGGTG------------------------------------------------------- 707
            |.|:|:..|.                                                       
Human   988 QETESENITSFVGTPENLQFQKEPNSAVFMSNIAPNQSDSFFRTQTSEKSKQLNTDKQPSEPSLD 1052

  Fly   708 --------------------------------------------------------------HGT 710
                                                                          |.|
Human  1053 SPCDKEKRKHLYRQAATELDACVDVTLVEKLKSVQINEKITVPHVMRAKKATLKAPVNRRMPHVT 1117

  Fly   711 RPIPLTP---MLSRS-------------------------------------------------- 722
            ....|:|   .||.:                                                  
Human  1118 STSKLSPTKRSLSETVTHRAKIMKIATKKRNSVHVTFRPSTESVQFYNPLENKEAPWKMRLRKLG 1182

  Fly   723 -YSEGS-------------------------------------------------------LASA 731
             :|.||                                                       :||:
Human  1183 GFSSGSSNSSTSNTHTSTNSATELVKPGVYRPLDTLGTASVSSKTVKESTEIPTTILQKEGIASS 1247

  Fly   732 ARSSRIRRRRA--------------------ATPKPKA-LQPSQLAENRINPQ------------ 763
            ...||...|.:                    |..|||| :.|.:  :||:.|:            
Human  1248 QLGSRSTLRSSSHEAGLQQGSLGGVYKTVVHALSKPKANVSPQR--QNRMPPEAPLRDLYSHVMG 1310

  Fly   764 --------------------------------DL------------------RRAMSLDSL---- 774
                                            ||                  ||..|..||    
Human  1311 YFGRKAAVNKEDMSQKLPPLNSDIGGSSANVPDLMDEFIAERLRSGNASTMTRRGSSPGSLEIPK 1375

  Fly   775 -----------------------------ARKGDAEETDSYQE---------------------- 788
                                         |...|...:||:.:                      
Human  1376 DLPDILNKQNQMRPIDDPGVPSEWTSPASAGSSDLISSDSHSDSFSAFQYDGRKFDNFGFGTDTG 1440

  Fly   789 ----GDNESGA---------------------------------------------------GSR 798
                .|.:||:                                                   |||
Human  1441 VTSSADVDSGSGHHQSAEEQEVASLTTLHIDSETSSLNQQAFSAEVATITGSESASPVHSPLGSR 1505

  Fly   799 SPSPTASS-GIEGGSIKDAQLQIDASL--------DDANSGSYGSGSNSGSISGRRCIILGGSAE 854
            |.:|:.|: .|:....||  ||:|..|        ||.....:.|...|        ::.||:..
Human  1506 SQTPSPSTLNIDHMEQKD--LQLDEKLHHSVLQTPDDLEISEFPSECCS--------VMAGGTLT 1560

  Fly   855 GWHPDSTSIMWKRMLGALGDVNRIPKADLHAQVFMHLLEMTQNLIKIKQNQGISTDNQNTQPMPP 919
            |||.|..::||:||||.|||||.|...::|||||.:|.|:.|||.||:.|.||||||. |.|.||
Human  1561 GWHADVATVMWRRMLGILGDVNSIMDPEIHAQVFDYLCELWQNLAKIRDNLGISTDNL-TSPSPP 1624

  Fly   920 -LVPPIGIVAPWCYGSLSLDRSFKKGKLWALQLLCSLAIQG---AVNMQQLPLFYHALHQLLTGE 980
             |:||:.|:.||.:.:..|...:|:|||.|.:|:|:...:.   :.|...|..||:.:|..|...
Human  1625 VLIPPLRILTPWLFKATMLTDKYKQGKLHAYKLICNTMKRRQDVSPNRDFLTHFYNIMHCGLLHI 1689

  Fly   981 DRDLIYAILKHLEGPRLLSLLLPGHTLLLLDLVHASAILLTSLEVSRSTPRAEVAALLGSLLCYP 1045
            |:|::..|:||. .|:..||.|||.|:|::|.:.|:..:.:|..:  :.||.|...|||||:|:|
Human  1690 DQDIVNTIIKHC-SPQFFSLGLPGATMLIMDFIVAAGRVASSAFL--NAPRVEAQVLLGSLVCFP 1751

  Fly  1046 SSLLTRSVLQPTPQKFELMECSDLQDHILNIVLRCARREPSAKARCIALSQLGQWLLMRLSQPLP 1110
            :.......|.|......:.:.:|:::.|:..||..||.|||..|||:||..||.|:...|     
Human  1752 NLYCELPSLHPNIPDVAVSQFTDVKELIIKTVLSSARDEPSGPARCVALCSLGIWICEEL----- 1811

  Fly  1111 ASNSGRANLFQQAVPHHKDVHPKASSVYNPRIKEVLQVLLQALQFKHHTIAIVAVDSLKLCAERG 1175
                               ||..    ::|:|||.|.|:..:|:|.:.|:|.||.:.|.:.....
Human  1812 -------------------VHES----HHPQIKEALNVICVSLKFTNKTVAHVACNMLHMLVHYV 1853

  Fly  1176 RQLAAIE-----RVPQLIITAICKALEIQSVTKPKDSDKVVLTSLMLCLGEFCMAIPAPIMLTPF 1235
            .:|...:     ::.|::|..|...|. .:.....:.||.::.||:|||.::.||:|...:|.||
Human  1854 PRLQIYQPDSPLKIIQILIATITHLLP-STEASSYEMDKRLVVSLLLCLLDWIMALPLKTLLQPF 1917

  Fly  1236 NEQG---DTLVLQVLRVLLQVASGA---------PRHERVKLT--ADDDFD--MHIAHDDLQGDG 1284
            :..|   |.....||..:.:|..|.         ||:..:.|:  |..|:|  ||:  :.|:...
Human  1918 HATGAESDKTEKSVLNCIYKVLHGCVYGAQCFSNPRYFPMSLSDLASVDYDPFMHL--ESLKEPE 1980

  Fly  1285 RLPEATYQTSETIQKCITAIK---------LCAKAVSMHLVTHIGHFPMGIGASRLSSMVEEQDD 1340
            .|.....:.|..:|. :|.:|         :.|:.|..|||.|:||:||..|.:.|:|.|.|..|
Human  1981 PLHSPDSERSSKLQP-VTEVKTQMQHGLISIAARTVITHLVNHLGHYPMSGGPAMLTSQVCENHD 2044

  Fly  1341 IGNAAYGGQVETRRDSVEL-PSVVSAQNMQLFMLNSGLVASFIELPTLK-LPGGGITAGLVTADK 1403
                      ....:|.|| |.:..:.|:|.|:||:..:.|.|::.:.: :||||::|||.:|:.
Human  2045 ----------NHYSESTELSPELFESPNIQFFVLNNTTLVSCIQIRSEENMPGGGLSAGLASANS 2099

  Fly  1404 QVRVLMRDLNGKACWDASILY--------SEP----------RNAEEPPKTTPKIQHSQPLDSMA 1450
            .||:::|||:||..||::|||        |||          ...||||.:...::.....|.::
Human  2100 NVRIIVRDLSGKYSWDSAILYGPPPVSGLSEPTSFMLSLSHQEKPEEPPTSNECLEDITVKDGLS 2164

  Fly  1451 TSMVTHTPSPRHTLRHRPAGVLPLAKDMAPDLDQLDDMLAYIGHTSPECVAPTVSQLNAPTASP- 1514
            ...            .|....:|....:..:.|.||::|.|:|.|||||:..|...||.|...| 
Human  2165 LQF------------KRFRETVPTWDTIRDEEDVLDELLQYLGVTSPECLQRTGISLNIPAPQPV 2217

  Fly  1515 -LSGNQEAQAISVILNQRLLEQEFVTHSTQAPSPALRHASS-NSSLQQPDQRSLHSTTASFDSLP 1577
             :|..||...|:.||.|...|:|||.          :|.:. |....:.|           :.:|
Human  2218 CISEKQENDVINAILKQHTEEKEFVE----------KHFNDLNMKAVEQD-----------EPIP 2261

  Fly  1578 TRTEMPFQYCRLLFSHLGLAGWERRSRTHLLQRSEKLMRELRNVDLQKCRETHKMAVIYVAAGQE 1642
            .:.:..|.|||||.|.||:..|::|...|||:::|||:|||||:|.::||||||:||.|||.|||
Human  2262 QKPQSAFYYCRLLLSILGMNSWDKRRSFHLLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQE 2326

  Fly  1643 DKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFLGGLPR-QGCGATAPYYATPFLEVVYHVATR 1706
            ||.|||.||.||..||.||:.||||::|..|.||:|||.: :..|.|.||:||..:||::||:||
Human  2327 DKHSILTNTGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQKNKSTGLTTPYFATSTVEVIFHVSTR 2391

  Fly  1707 MPSDSSEAMLLKTRHLGNDEVHIVWSEHNRDYRRDILPTEFCDVLIVVYPLRNGLFRVTVNRKPE 1771
            |||||.:::..|.|||||||||||||||.|||||.|:||||.|||||:||::|.:|.:.:.:|||
Human  2392 MPSDSDDSLTKKLRHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPE 2456

  Fly  1772 VPWFGPLANESVVSGACLATLIRATAINASRTKRAALPLYQQFYEERNRSLDSVSSRYKESTTFE 1836
            ||:||||.:.::|:|..|..::|||||||||..::.:||||.|||||.|.|.::...:.|.||||
Human  2457 VPFFGPLFDGAIVNGKVLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2521

  Fly  1837 DFASRIYNPMPLSTLGTLRESNASSSAAPLASALLDHNRASVKGWVQASIDSGPIMGIAPSASAG 1901
            |||:::::|.|...|    .|:|                                :|..|.....
Human  2522 DFAAQVFSPAPYHHL----PSDA--------------------------------VGSYPEILPS 2550

  Fly  1902 STAAMEAATGMSSASPRGPR 1921
            .|.......|...|||..||
Human  2551 ETPTATQVDGADLASPMSPR 2570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5521NP_001163748.1 Rap_GAP 1648..1820 CDD:280332 102/172 (59%)
RALGAPA1XP_006720161.1 Rap_GAP 2332..2508 CDD:280332 103/175 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144554
Domainoid 1 1.000 784 1.000 Domainoid score I78
eggNOG 1 0.900 - - E1_KOG3686
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H84805
Inparanoid 1 1.050 1029 1.000 Inparanoid score I272
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47016
OrthoDB 1 1.010 - - D157372at2759
OrthoFinder 1 1.000 - - FOG0003646
OrthoInspector 1 1.000 - - otm41406
orthoMCL 1 0.900 - - OOG6_103120
Panther 1 1.100 - - O PTHR10063
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4248
SonicParanoid 1 1.000 - - X2517
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

Return to query results.
Submit another query.