|
Fly 1 MFTKKSHADVKKSTAKLQDSKKDSASRLRHLRMILDNVELEESKCLFETNYSHVYFILYDTFIQA 65
||:||.|.||||||.|:.|:|||:.:||:|||::::|.|..:.|..|:.::||:|::.::.|:..
Human 1 MFSKKPHGDVKKSTQKVLDTKKDALTRLKHLRIVIENAESIDLKQFFDQHFSHIYYVFFENFVTI 65
Fly 66 EANLKQKELPFHIVHKAHREELDGSLWLLEKILCLLPELLARRWQCHSLSRIMAKLLHLGNSPKL 130
||:||||. ||:.|||||..|::.||||.||||.:.:|||.||:..|:.||||.|||.|:
Human 66 EASLKQKG------HKSQREELDAILFIFEKILQLLPERIHQRWQFHSIGLILKKLLHTGNSLKI 124
Fly 131 RREGVRYFLLWYQTLGENAPGYVHAMYADLIPGLIVPQKGVVGPDTEFSASDFLTHPNMKADGGM 195
||||||.||||.|.|..|.......|::.||||...|| ...||.| .|.|.:|.:
Human 125 RREGVRLFLLWLQALQNNCSKEQLWMFSCLIPGFSAPQ-SEHGPRT----LDNLINPPL------ 178
Fly 196 ASVFHDNAFSHPVQSSEVVALLPPSSSEKSAPPDPRDGLEVLLNSMVHTAACLRWRDNRAQKDHR 260
|.....|...|:..|:||.|.:|.........||.||..:|.....|.|::...|: |
Human 179 ------NLQETQVTIEEITPLVPPQSGDKGQEDLTSYFLEALLKYIVIQVKSLEWKNKENQE--R 235
Fly 261 AFAFLLQRFMDVFLPVFSPNFDVSCSIYNPRLDLPVMRS-----INKKE-----------EVMAS 309
.|:||...|...:||...||.....|:|:|.||:|.||. :.||: |....
Human 236 GFSFLFSHFKKYYLPYIFPNICKENSLYHPILDIPQMRPKPHYVVIKKDAETNEAIYCTKEPFIK 300
Fly 310 CVVVLINWVSRF-----------------------------------------------THERLL 327
..|::|.|:..| |.|...
Human 301 ARVIVIRWLVSFWLEPKPHTGPHIPGMEGEVLPKNIQRAAASLVSREESKNDNADKTDRTTEPEQ 365
Fly 328 SHRLDCTL----------------HIEDVDQVRLHGYQQGLIVRDVLYVNRENINFVHEVYRQAF 376
||....|| |:.|:: |||.|....|.|:|||.|::||||
Human 366 SHSNTSTLTEREPSSSSLCSIDEEHLTDIE-----------IVRRVFSSKRSNVNFVTEIFRQAF 419
Fly 377 LLNFTSKPQIEAIRTAIAVYRDWMTGETPPPFLLEPND------DPPPPSNA------------- 422
||... :..|:|..:.||::|:..|..|.|:.||.: |.|...|.
Human 420 LLPIC---EAAAMRKVVKVYQEWIQQEEKPLFMQEPEEIVITSSDLPCIENVTDHDISMEEGEKR 481
Fly 423 ---GGTPRSQRLRTP------SYVGAIAGSKDQLV---VRAGRQNVLQVFVTNAANVFLVNTAN- 474
.||..:..:|.. ||.||:..:.::.. :|||.|.|||||:.|::|:||:..||
Human 482 EEENGTNTADHVRNSSWAKNGSYQGALHNASEEATEQNIRAGTQAVLQVFIINSSNIFLLEPANE 546
Fly 475 -LNICFPTRSRSYRSTPLEEQTEICKKVLNVYRTMVMNTEMDTRTWEQLLMVLLQVTSIVLHQ-N 537
.|: |:|.|::||::||:||.||:...||.:||||:|:|||:||..||.. :
Human 547 IKNL-------------LDEHTDMCKRILNIYRYMVVQVSMDKKTWEQMLLVLLRVTESVLKMPS 598
Fly 538 QHTLPSGTNKSATLGGILGSAIFQTLIVTWIRAHTKVPVNVLLWEKFLNVLQSLTHREELIIEWN 602
|..|.....|:.||.|.|...:||||||.||:|:..|.::..||:..|:||.|||:.|||..||:
Human 599 QAFLQFQGKKNMTLAGRLAGPLFQTLIVAWIKANLNVYISRELWDDLLSVLSSLTYWEELATEWS 663
Fly 603 KTIQTLTRVFSRYTYGINLLDLPLDRVAESRAEKRRRIG--------SV-------W-------- 644
.|::|||:|.:|..|.::|.|||||:::|.:.:|.:..| || |
Human 664 LTMETLTKVLARNLYSLDLSDLPLDKLSEQKQKKHKGKGVGHEFQKVSVDKSFSRGWSRDQPGQA 728
Fly 645 ---QGSGSNSAANGGSAASAAISQN----RQRESLAESS-------------------------- 676
|.|.:.:.:.|...|.:.:.|. |.| |:.|.:
Human 729 PMRQRSATTTGSPGTEKARSIVRQKTVAMRSR-SIGECALPSAYIRSAKSAPVLIHTSKPFLPDI 792
Fly 677 --------------------------SSRSEETSSQV--------PLP----------------- 690
.|:||||.::| |||
Human 793 VLTPLSDELSDIDDAQILPRSTRVRHFSQSEETGNEVFGALNEEQPLPRSSSTSDILEPFTVERA 857
Fly 691 ----------------------------------------------------------------- 690
Human 858 KGAVPVIDSSSRHAPSLQSSTEASSITRSTESHITDTHSRESSLEVGDSIYDHLCHLIGPVELAD 922
Fly 691 ------------------------------NHPRPH----------------------------H 697
||.:.. .
Human 923 SAFEQIQYIDLEGDDDLLSTLKEYFKENQENHSKNETGKDPASQEVTIAVNRGERLSLDKLECTD 987
Fly 698 QHTQSQGGTG------------------------------------------------------- 707
|.|:|:..|.
Human 988 QETESENITSFVGTPENLQFQKEPNSAVFMSNIAPNQSDSFFRTQTSEKSKQLNTDKQPSEPSLD 1052
Fly 708 --------------------------------------------------------------HGT 710
|.|
Human 1053 SPCDKEKRKHLYRQAATELDACVDVTLVEKLKSVQINEKITVPHVMRAKKATLKAPVNRRMPHVT 1117
Fly 711 RPIPLTP---MLSRS-------------------------------------------------- 722
....|:| .||.:
Human 1118 STSKLSPTKRSLSETVTHRAKIMKIATKKRNSVHVTFRPSTESVQFYNPLENKEAPWKMRLRKLG 1182
Fly 723 -YSEGS-------------------------------------------------------LASA 731
:|.|| :||:
Human 1183 GFSSGSSNSSTSNTHTSTNSATELVKPGVYRPLDTLGTASVSSKTVKESTEIPTTILQKEGIASS 1247
Fly 732 ARSSRIRRRRA--------------------ATPKPKA-LQPSQLAENRINPQ------------ 763
...||...|.: |..|||| :.|.: :||:.|:
Human 1248 QLGSRSTLRSSSHEAGLQQGSLGGVYKTVVHALSKPKANVSPQR--QNRMPPEAPLRDLYSHVMG 1310
Fly 764 --------------------------------DL------------------RRAMSLDSL---- 774
|| ||..|..||
Human 1311 YFGRKAAVNKEDMSQKLPPLNSDIGGSSANVPDLMDEFIAERLRSGNASTMTRRGSSPGSLEIPK 1375
Fly 775 -----------------------------ARKGDAEETDSYQE---------------------- 788
|...|...:||:.:
Human 1376 DLPDILNKQNQMRPIDDPGVPSEWTSPASAGSSDLISSDSHSDSFSAFQYDGRKFDNFGFGTDTG 1440
Fly 789 ----GDNESGA---------------------------------------------------GSR 798
.|.:||: |||
Human 1441 VTSSADVDSGSGHHQSAEEQEVASLTTLHIDSETSSLNQQAFSAEVATITGSESASPVHSPLGSR 1505
Fly 799 SPSPTASS-GIEGGSIKDAQLQIDASL--------DDANSGSYGSGSNSGSISGRRCIILGGSAE 854
|.:|:.|: .|:....|| ||:|..| ||.....:.|...| ::.||:..
Human 1506 SQTPSPSTLNIDHMEQKD--LQLDEKLHHSVLQTPDDLEISEFPSECCS--------VMAGGTLT 1560
Fly 855 GWHPDSTSIMWKRMLGALGDVNRIPKADLHAQVFMHLLEMTQNLIKIKQNQGISTDNQNTQPMPP 919
|||.|..::||:||||.|||||.|...::|||||.:|.|:.|||.||:.|.||||||. |.|.||
Human 1561 GWHADVATVMWRRMLGILGDVNSIMDPEIHAQVFDYLCELWQNLAKIRDNLGISTDNL-TSPSPP 1624
Fly 920 -LVPPIGIVAPWCYGSLSLDRSFKKGKLWALQLLCSLAIQG---AVNMQQLPLFYHALHQLLTGE 980
|:||:.|:.||.:.:..|...:|:|||.|.:|:|:...:. :.|...|..||:.:|..|...
Human 1625 VLIPPLRILTPWLFKATMLTDKYKQGKLHAYKLICNTMKRRQDVSPNRDFLTHFYNIMHCGLLHI 1689
Fly 981 DRDLIYAILKHLEGPRLLSLLLPGHTLLLLDLVHASAILLTSLEVSRSTPRAEVAALLGSLLCYP 1045
|:|::..|:||. .|:..||.|||.|:|::|.:.|:..:.:|..: :.||.|...|||||:|:|
Human 1690 DQDIVNTIIKHC-SPQFFSLGLPGATMLIMDFIVAAGRVASSAFL--NAPRVEAQVLLGSLVCFP 1751
Fly 1046 SSLLTRSVLQPTPQKFELMECSDLQDHILNIVLRCARREPSAKARCIALSQLGQWLLMRLSQPLP 1110
:.......|.|......:.:.:|:::.|:..||..||.|||..|||:||..||.|:...|
Human 1752 NLYCELPSLHPNIPDVAVSQFTDVKELIIKTVLSSARDEPSGPARCVALCSLGIWICEEL----- 1811
Fly 1111 ASNSGRANLFQQAVPHHKDVHPKASSVYNPRIKEVLQVLLQALQFKHHTIAIVAVDSLKLCAERG 1175
||.. ::|:|||.|.|:..:|:|.:.|:|.||.:.|.:.....
Human 1812 -------------------VHES----HHPQIKEALNVICVSLKFTNKTVAHVACNMLHMLVHYV 1853
Fly 1176 RQLAAIE-----RVPQLIITAICKALEIQSVTKPKDSDKVVLTSLMLCLGEFCMAIPAPIMLTPF 1235
.:|...: ::.|::|..|...|. .:.....:.||.::.||:|||.::.||:|...:|.||
Human 1854 PRLQIYQPDSPLKIIQILIATITHLLP-STEASSYEMDKRLVVSLLLCLLDWIMALPLKTLLQPF 1917
Fly 1236 NEQG---DTLVLQVLRVLLQVASGA---------PRHERVKLT--ADDDFD--MHIAHDDLQGDG 1284
:..| |.....||..:.:|..|. ||:..:.|: |..|:| ||: :.|:...
Human 1918 HATGAESDKTEKSVLNCIYKVLHGCVYGAQCFSNPRYFPMSLSDLASVDYDPFMHL--ESLKEPE 1980
Fly 1285 RLPEATYQTSETIQKCITAIK---------LCAKAVSMHLVTHIGHFPMGIGASRLSSMVEEQDD 1340
.|.....:.|..:|. :|.:| :.|:.|..|||.|:||:||..|.:.|:|.|.|..|
Human 1981 PLHSPDSERSSKLQP-VTEVKTQMQHGLISIAARTVITHLVNHLGHYPMSGGPAMLTSQVCENHD 2044
Fly 1341 IGNAAYGGQVETRRDSVEL-PSVVSAQNMQLFMLNSGLVASFIELPTLK-LPGGGITAGLVTADK 1403
....:|.|| |.:..:.|:|.|:||:..:.|.|::.:.: :||||::|||.:|:.
Human 2045 ----------NHYSESTELSPELFESPNIQFFVLNNTTLVSCIQIRSEENMPGGGLSAGLASANS 2099
Fly 1404 QVRVLMRDLNGKACWDASILY--------SEP----------RNAEEPPKTTPKIQHSQPLDSMA 1450
.||:::|||:||..||::||| ||| ...||||.:...::.....|.::
Human 2100 NVRIIVRDLSGKYSWDSAILYGPPPVSGLSEPTSFMLSLSHQEKPEEPPTSNECLEDITVKDGLS 2164
Fly 1451 TSMVTHTPSPRHTLRHRPAGVLPLAKDMAPDLDQLDDMLAYIGHTSPECVAPTVSQLNAPTASP- 1514
... .|....:|....:..:.|.||::|.|:|.|||||:..|...||.|...|
Human 2165 LQF------------KRFRETVPTWDTIRDEEDVLDELLQYLGVTSPECLQRTGISLNIPAPQPV 2217
Fly 1515 -LSGNQEAQAISVILNQRLLEQEFVTHSTQAPSPALRHASS-NSSLQQPDQRSLHSTTASFDSLP 1577
:|..||...|:.||.|...|:|||. :|.:. |....:.| :.:|
Human 2218 CISEKQENDVINAILKQHTEEKEFVE----------KHFNDLNMKAVEQD-----------EPIP 2261
Fly 1578 TRTEMPFQYCRLLFSHLGLAGWERRSRTHLLQRSEKLMRELRNVDLQKCRETHKMAVIYVAAGQE 1642
.:.:..|.|||||.|.||:..|::|...|||:::|||:|||||:|.::||||||:||.|||.|||
Human 2262 QKPQSAFYYCRLLLSILGMNSWDKRRSFHLLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQE 2326
Fly 1643 DKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFLGGLPR-QGCGATAPYYATPFLEVVYHVATR 1706
||.|||.||.||..||.||:.||||::|..|.||:|||.: :..|.|.||:||..:||::||:||
Human 2327 DKHSILTNTGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQKNKSTGLTTPYFATSTVEVIFHVSTR 2391
Fly 1707 MPSDSSEAMLLKTRHLGNDEVHIVWSEHNRDYRRDILPTEFCDVLIVVYPLRNGLFRVTVNRKPE 1771
|||||.:::..|.|||||||||||||||.|||||.|:||||.|||||:||::|.:|.:.:.:|||
Human 2392 MPSDSDDSLTKKLRHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPE 2456
Fly 1772 VPWFGPLANESVVSGACLATLIRATAINASRTKRAALPLYQQFYEERNRSLDSVSSRYKESTTFE 1836
||:||||.:.::|:|..|..::|||||||||..::.:||||.|||||.|.|.::...:.|.||||
Human 2457 VPFFGPLFDGAIVNGKVLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2521
Fly 1837 DFASRIYNPMPLSTLGTLRESNASSSAAPLASALLDHNRASVKGWVQASIDSGPIMGIAPSASAG 1901
|||:::::|.|...| .|:| :|..|.....
Human 2522 DFAAQVFSPAPYHHL----PSDA--------------------------------VGSYPEILPS 2550
Fly 1902 STAAMEAATGMSSASPRGPR 1921
.|.......|...|||..||
Human 2551 ETPTATQVDGADLASPMSPR 2570
| 
