DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5521 and Sipa1l2

DIOPT Version :9

Sequence 1:	NP_001163748.1	Gene:	CG5521 / 43242	FlyBaseID:	FBgn0039466	Length:	1964	Species:	Drosophila melanogaster
Sequence 2:	NP_001074806.1	Gene:	Sipa1l2 / 244668	MGIID:	2676970	Length:	1722	Species:	Mus musculus

Alignment Length:	320	Identity:	74/320 - (23%)
Similarity:	122/320 - (38%)	Gaps:	45/320 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1611 SEKLMRELRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLETHNG 1675
            |.|:..:|..:|.|.....||:.::|..|||..:..:..|.:....:|.|:..||..:.|:..:.
Mouse   589 SPKVPEQLLKLDEQGLSFQHKIGILYCRAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSK 653

  Fly  1676 FLGGLPRQ--GCGATAPYYATPFLEVVYHVATRMP-SDSSEAMLLKTRHLGNDEVHIVWSEHNRD 1737
            :...|..:  ..|..:.|......|:::||:|.:| ..::...||:.||:|||.|.||:.|..
Mouse   654 YRAQLDNKTDSTGTHSLYTTYKDFELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPG-- 716

  Fly  1738 YRRDILP-------TEFCDVLIVVYP----LRNGLFRVTVNRKPEVPWFGPLANESVV--SGACL 1789
                .||       :.|..|.::|..    ..|..:.|.|:|..:||.|||...:.|.  ..|..
Mouse   717 ----ALPFTPKNIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVF 777

  Fly  1790 ATLIRATAINASRTKRAALPLYQQFYEERNRSLDSVSSRYKESTTFEDFASRIYNPMPLSTLGTL 1854
            ...:.|..|||......:..........|...|..::..:..:.|.:..|.     ....|||..
Mouse   778 RDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSAK-----FSFITLGAK 837

  Fly  1855 RESNASSSAAPLASALLDHNRASVKGWVQASIDSGPIMGIAPSASAGSTAAMEAATGMSS 1914
            ::....    |...|.|              ...|.||....:...|.:|.:|...|:|:
Mouse   838 KKERVK----PRKDAHL--------------FSIGAIMWHVVARDFGQSADIECLLGISN 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	Rap_GAP	1648..1820	CDD:280332	46/187 (25%)
Sipa1l2	NP_001074806.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..72
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..405
		Rap_GAP	626..806	CDD:366939	45/185 (24%)
		PDZ_signaling	951..1021	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1068..1246
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1331..1360
		SPAR_C	1423..1666	CDD:371778
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810