DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5521 and Ralgapa2

DIOPT Version :9

Sequence 1:NP_001163748.1 Gene:CG5521 / 43242 FlyBaseID:FBgn0039466 Length:1964 Species:Drosophila melanogaster
Sequence 2:XP_006499580.1 Gene:Ralgapa2 / 241694 MGIID:3036245 Length:1966 Species:Mus musculus


Alignment Length:2133 Identity:706/2133 - (33%)
Similarity:1032/2133 - (48%) Gaps:437/2133 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFTKKSHADVKKSTAKLQDSKKDSASRLRHLRMILDNVELEESKCLFETNYSHVYFILYDTFIQA 65
            ||:::||.||||||.|:.|.|||..:||:|||.:||||:..:.|..||||||.:|||.|:.||..
Mouse     1 MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDASDLKQFFETNYSQIYFIFYENFITL 65

  Fly    66 EANLKQKELPFHIVHKAHREELDGSLWLLEKILCLLPELLARRWQCHSLSRIMAKLLHLGNSPKL 130
            |.:||.|.     .:|:.|||||..|:|.||||..|||.:..||...|:...:.||||.|||.|:
Mouse    66 ENSLKLKG-----NNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTGNSIKI 125

  Fly   131 RREGVRYFLLWYQTLGENAPGYVHAMYADLIPGL--IVPQKGVVGPDTEFSASDFLTHPNMKADG 193
            |.||:|.||||.|.|..|.......::|.|:||.  ::..:|....:|..:.|..:.        
Mouse   126 RCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVLSSRGPCTLETLINPSPSIV-------- 182

  Fly   194 GMASVFHDNAFSHPVQSSEVVALLPPSSSEKSAPPDPRDGLEVLLNSMVHTAACLRWRDNRAQKD 258
                    :|..:|   .|:..|||..|.||.|.......|::||..||..||.|.|: |:..:|
Mouse   183 --------DAKIYP---EEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWK-NKENQD 235

  Fly   259 HRAFAFLLQRFMDVFLPVFSPNFDVSCSIYNPRLDLPVMR------SINKKEEVMAS-------C 310
             ..|.||...|...:||...|:|....:||.|.|::|.:|      ::.:..|.:.|       .
Mouse   236 -TGFKFLFTLFRKYYLPHLFPSFTKLTNIYKPVLEIPHLRPKPVYVTVTRDNETIYSTKIPYMAA 299

  Fly   311 VVVLINWVSRFTHERLLSHRLDCTLHIEDV--------------------------DQVRLHGYQ 349
            .||.|.|:..|..|:........|.:..||                          :|.:.|...
Mouse   300 RVVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAIQEKVPELDGAGSTEQDKSHSNS 364

  Fly   350 QGL----------------------IVRDVLYVNRENINFVHEVYRQAFLLNFTSKPQIEAIRTA 392
            ..|                      :|:.:|...|..:|||:||:||||||   ...:|...|..
Mouse   365 STLSDRRLSNSSLCSIEEEHRTVYEMVQRILLSTRGYVNFVNEVFRQAFLL---PSCEISVTRKV 426

  Fly   393 IAVYRDWMTGETPPPFLLEPN-----------------DDPPPPSNAGGTPRSQRL-RTPSYVGA 439
            :.|||.|:. :..|.|:.||:                 |.....|.:.|..||... ||.|:..|
Mouse   427 VQVYRKWIL-QNKPVFMEEPDKKDVAQEDADKLGLSETDSKEASSESSGHKRSSSWGRTYSFTSA 490

  Fly   440 IA----GSKDQLVVRAGRQNVLQVFVTNAANVFLVNTANLNICFPTRSRSYRSTP--LEEQTEIC 498
            ::    ..:|...|:||.|.:||||:||||||||     |..|        ...|  |.||.:..
Mouse   491 MSRGCVTEEDNTNVKAGAQAMLQVFLTNAANVFL-----LEPC--------AEVPMLLREQVDAS 542

  Fly   499 KKVLNVYRTMVMNTEMDTRTWEQLLMVLLQVTSIVLHQNQHTLPSGTNKSATLGGILGSAIFQTL 563
            |.||.::|.|:|...|:.:||||:|.:||::|..|:.:     |...:........|...:|:||
Mouse   543 KAVLIIFRRMIMELTMNQKTWEQMLQILLRITEAVMQK-----PKDKHVKDLFAQSLAGLLFRTL 602

  Fly   564 IVTWIRAHTKVPVNVLLWEKFLNVLQSLTHREELIIEWNKTIQTLTRVFSRYTYGINLLDLPLDR 628
            ||.||||:..|.::..||:.||.||.|||..||||.||:..:.:||.|.:|..||:.:.:||||:
Mouse   603 IVAWIRANLCVYISRELWDDFLRVLSSLTEWEELITEWSNIMDSLTAVLARTVYGVEMTNLPLDK 667

  Fly   629 VAESRAEKRRRIGSV----------------WQG-----------SGSNSAANGGSAASAAISQN 666
            ::|.:.:|:|..|.:                |:.           |.:.|.|.|...|...:.|.
Mouse   668 LSEQKEKKQRGKGCILEPQKGTAVGRSFSLSWRSHPDVTEPMRFRSATTSGAPGVEKARNTVRQK 732

  Fly   667 ------------------------------------------------------RQRESLAES-- 675
                                                                  :|.||.|.:  
Mouse   733 ATAKRSQSISNCVHLSEALPATKSVPLLLHTVSALLPGLSYSSCSHRLSEVEEFQQAESTAAADC 797

  Fly   676 ------------SSSRSEET------SSQVPLPNHPRPHHQHT---QSQGGTGHGTRPIPLTPML 719
                        |||.|:.|      |||...|..|.|....|   ||.|.......|:|    |
Mouse   798 DYLVVGQQQVPRSSSTSDITERLYSDSSQGYSPMLPHPAFSTTSGDQSSGPHACTAGPLP----L 858

  Fly   720 SRSYSEGSLASAARSSRIRRRRAATPKPKALQPSQ---LAENRINPQDLRRAMSLDSLARKGDAE 781
            ||..|.|.....:::       .::.:||::|.|:   ..|:......:||:.|...|..|.|.:
Mouse   859 SRLPSAGQKVEHSQN-------LSSSEPKSVQESKGHVTHEHEGITMLVRRSSSPAELELKDDLQ 916

  Fly   782 ETDSYQEGDNESGAGSRSPSPTASSGIEGGSIKDAQLQI----------------DASLD-DANS 829
            :.        ......|..|.:..|....|...:|:|.:                ||..| ||..
Mouse   917 QA--------HGRCRQRQTSESTGSDTVVGYSNEAELPVSPWQACEEDPDLSTPTDAVADSDARH 973

  Fly   830 GSYGSGSNSGSIS-GRRC------IILGGSAEGWHPDSTSIMWKRMLGALGDVNRIPKADLHAQV 887
            ....|.:::.::: .|.|      ||.||:..||||||.:::|:|:||.|||||.|....:||:|
Mouse   974 WLQLSPTDASNLTDSRECLADDCSIIAGGNLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHAKV 1038

  Fly   888 FMHLLEMTQNLIKIKQNQGISTDNQNTQPMPPLVPPIGIVAPWCYGSLSLDRSFKKGKLWALQLL 952
            |.:|.|:...|.||:.|..||.|||::...|.|:||:.:.|.|.:.:.:|...:|:|||.|.:|:
Mouse  1039 FGYLYELWYKLAKIRDNLAISLDNQSSPSPPLLIPPLRMFASWLFKATTLPNEYKEGKLQAYKLI 1103

  Fly   953 CSLAIQG---AVNMQQLPLFYHALHQLLTGEDRDLIYAILKHLEGPRLLSLLLPGHTLLLLDLVH 1014
            |::..:.   ..|...|..||..:|..||.||:|::..|:|:. .||..||.|||.::|:.|.:.
Mouse  1104 CAMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDVLNTIIKNC-SPRFFSLGLPGFSMLVGDFIT 1167

  Fly  1015 ASA-ILLTSLEVSRSTPRAEVAALLGSLLCYPSSLLTRSVLQPTPQKFELME-CSDLQDHILNIV 1077
            |:| :|.|.:   .:.||:|...|||||:|:|::.....:||..|:..:::. ..|::.:::||:
Mouse  1168 AAARVLSTDM---LAAPRSEALTLLGSLVCFPNTYQEIPLLQSVPEVSDVVTGAEDVKHYLINIL 1229

  Fly  1078 LRCARREPSAKARCIALSQLGQWLLMRLSQPLPASNSGRANLFQQAVPHHKDVHPKASSVYNPRI 1142
            |:.|..||:..|||||:..||.|:...|:|                            |..:|::
Mouse  1230 LKNATEEPNECARCIAICSLGVWICEELAQ----------------------------SASHPQV 1266

  Fly  1143 KEVLQVLLQALQFKHHTIAIVAVDSLKLCAERGRQLAAIE-----RVPQLIITAICKAL---EIQ 1199
            |:.:.|:...|:|.:..:|.||.|.|:|......:|...|     ::.::::..|...|   |..
Mouse  1267 KDAINVIGVTLKFPNKIVAQVACDVLQLLVSYWEKLQMFETALPRKMAEILVATIAFLLPSAEYS 1331

  Fly  1200 SVTKPKDSDKVVLTSLMLCLGEFCMAIPAPIMLTPFNEQGDTLVLQ------------VLRVLLQ 1252
            ||    ::||..:.||:|||.::|||:|...:|.|.:    |.||:            :.|||..
Mouse  1332 SV----ETDKKFIVSLLLCLLDWCMALPVSALLHPVS----TAVLEELHPSRAPLLDYIYRVLHC 1388

  Fly  1253 VASGAPRHERVKLTADDDFDMHIAHDDLQG---DGRLPEATYQTSETIQ---------------- 1298
            ...|:..:     |....:.:.:|  ||..   |..||.|..:.||.||                
Mouse  1389 CVCGSSTY-----TQQSHYTLTLA--DLSSTDYDPFLPLANVRNSEPIQYHSSADLGNLLTVEEE 1446

  Fly  1299 ---KCITAIKLCAKAVSMHLVTHIGHFPMGIGASRLSSMVEEQDDIGNAAYGGQVETRRDSVELP 1360
               :.:..|.|.|:.|..|||.|:||:|:..|.:.|.|:|.|..|  ||...|        .||.
Mouse  1447 KKRRSVELIPLTARMVMAHLVNHLGHYPLSGGPAVLHSLVSENHD--NAHVEG--------TELS 1501

  Fly  1361 S-VVSAQNMQLFMLNSGLVASFIELPTLKLPGGGITAGLVTADKQVRVLMRDLNGKACWDASILY 1424
            | |..:.|:|||:.|...:.|:::.|. :.|.||.:.|.::   .|||::||::||..||..:||
Mouse  1502 SEVFRSPNLQLFVFNDSTLISYLQTPA-EGPAGGTSGGSLS---DVRVIVRDISGKYSWDGKVLY 1562

  Fly  1425 SEPRNAEEPPKTTPKIQHSQPLDSMATSMVTHTPSPRHTLRHRPAGVLPLAKDMAPDLDQLDDML 1489
            ........|....|..|.|        ....||..|:..|.:...|.           |.||.:|
Mouse  1563 GPLEGRLAPNGRNPSFQIS--------GWHHHTCGPQKDLFNGEEGD-----------DVLDKLL 1608

  Fly  1490 AYIGHTSPECVAPTVSQLNAPTASPLSGN--QEAQAISVILNQRLLEQEFVTHSTQAPSPALRHA 1552
            ..||||||||:.|:...||.|:.:|.:.|  ||...:.|||.|...|.|:|           :..
Mouse  1609 ENIGHTSPECLLPSQLNLNEPSPTPCAMNWDQEKAIMEVILRQSAQEDEYV-----------QRC 1662

  Fly  1553 SSNSSLQQPDQRSLHSTTASFDSLPTRTEMPFQYCRLLFSHLGLAGWERRSRTHLLQRSEKLMRE 1617
            :|:||:         :.|:.....|.....||.:||||...||:..|:||...|||:::.||:||
Mouse  1663 NSDSSV---------TVTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRKNFHLLKKNSKLLRE 1718

  Fly  1618 LRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFLGGLPR 1682
            |:|:|.::||||||:||.|:|.|||||.|||.|..||..||.||:.||||:||.||.||:|||.|
Mouse  1719 LKNLDSRQCRETHKIAVFYIAEGQEDKCSILANERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQR 1783

  Fly  1683 QG-CGATAPYYATPFLEVVYHVATRMPSDSSEAMLLKTRHLGNDEVHIVWSEHNRDYRRDILPTE 1746
            .| .|.|||||||..:||::||:|||||||.:::..|.|||||||||||||||:|||||.|:||.
Mouse  1784 NGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTA 1848

  Fly  1747 FCDVLIVVYPLRNGLFRVTVNRKPEVPWFGPLANESVVSGACLATLIRATAINASRTKRAALPLY 1811
            |.||.|::||::|.:|.:|:.:|||||:||||.:.::|||..|.:||.||.|||||..:..:|||
Mouse  1849 FGDVSIIIYPMKNHMFFITITKKPEVPFFGPLFDGAIVSGKLLPSLICATCINASRAVKCLIPLY 1913

  Fly  1812 QQFYEERNRSLDSVSSRYKESTTFEDFASRIYNPMP-LSTLGTLRESNASSSA 1863
            |.|||||...|:::...::|..||||||:::::|.| .|..||::|...|:::
Mouse  1914 QSFYEERALYLEAIIQNHREVMTFEDFAAQVFSPSPSYSVSGTVKEQEESTAS 1966

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5521NP_001163748.1 Rap_GAP 1648..1820 CDD:280332 106/172 (62%)
Ralgapa2XP_006499580.1 Rap_GAP 1749..1921 CDD:366939 105/171 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 213 1.000 Domainoid score I2743
eggNOG 1 0.900 - - E1_KOG3686
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S6751
OMA 1 1.010 - - QHG47016
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003646
OrthoInspector 1 1.000 - - otm43459
orthoMCL 1 0.900 - - OOG6_103120
Panther 1 1.100 - - LDO PTHR10063
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4248
SonicParanoid 1 1.000 - - X2517
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.760

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