DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5521 and Sipa1

DIOPT Version :9

Sequence 1:	NP_001163748.1	Gene:	CG5521 / 43242	FlyBaseID:	FBgn0039466	Length:	1964	Species:	Drosophila melanogaster
Sequence 2:	NP_001157952.1	Gene:	Sipa1 / 20469	MGIID:	107576	Length:	1038	Species:	Mus musculus

Alignment Length:	606	Identity:	139/606 - (22%)
Similarity:	228/606 - (37%)	Gaps:	125/606 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1372 MLNSGLVASFIELPTLKLPGGGITAGLVTADKQVRVLMRDLNGKACWDASILYSEP-----RNAE 1431
            :|.||..|..:..||             .|..:.|....:...:.....:.|:::|     ..||
Mouse    48 LLRSGSDAGEVRPPT-------------PASPRARAHSHEDASRPAATPTRLFTDPLALLGLPAE 99

  Fly  1432 EPPKTTPKIQHSQ-----PLDSMATSMVTHTPSPRHTLRHRPAGVLPLAKDMAPDLDQLDDMLAY 1491
            ||..|.|.:...:     .:.|:   :....|.||.|..|..|....||:......|.|.....:
Mouse   100 EPEPTFPPVLEPRWFAHYDVQSL---LFDWAPRPRGTGSHIEANSGTLAEGQTTTSDLLLGAPGF 161

  Fly  1492 IGHTSPECVAPTVSQLNAPTASPLSGNQEAQAISVILNQRLLEQEFVTHSTQAPSPALRHASSNS 1556
            :.....|    ....|..|.:.|:.......|:||      ||:.    .|:..:.:|.||...:
Mouse   162 VSELGGE----GELGLGGPISPPVPPALPNAAVSV------LEEP----QTRTTAYSLEHADLGA 212

  Fly  1557 ---------------------------SLQQPDQR-----SLHS--------------TTASFDS 1575
                                       ||::.::.     :|||              .|.|.|:
Mouse   213 GYYRKYFYGKEHQNFFGLDEALGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTISEDA 277

  Fly  1576 L---PTRTEMPFQYCRLLFSHLGLAGWERRSRT--HLLQRSEKLMRELRNVDLQKCRETHKMAVI 1635
            |   |.|...|    |.|..|:.    .|.|.|  .|...|.|:.|.|..:|.|......|:.::
Mouse   278 LPPGPPRGLSP----RKLLEHVA----PRLSPTCLRLGSASPKVPRTLLTLDEQVLSFQRKVGIL 334

  Fly  1636 YVAAGQEDKGSILRNTSGSSTYEMFVSALGWEIDLETHNGFLGGLPRQ--GCGATAPYYATPFLE 1698
            |..|||..:..:..|....:.:..|::.||..:.|:....:...|..:  ..|..:.|......|
Mouse   335 YCRAGQGSEEEMYNNQEAGAAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHE 399

  Fly  1699 VVYHVATRMP-SDSSEAMLLKTRHLGNDEVHIVWSE-HNRDYRRDILPTEFCDVLIVVYP----L 1757
            :::||:|.:| :.:::..||:.||:|||.|.||:.| .::.:....:.:.|..|.:||..    .
Mouse   400 IMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHAPCT 464

  Fly  1758 RNGLFRVTVNRKPEVPWFGPLANES---VVSGACLATLIRATAINASRTKRAALPLYQQFYEERN 1819
            .:..:||.|:|..:.|.|||...|.   ..:.|.....:.|.|:|..:....|...:......|.
Mouse   465 PHTSYRVAVSRTQDTPAFGPALPEGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQ 529

  Fly  1820 RSLDSVSSRYKESTTFEDFASRIYNPMPLSTLGTLRESNASSSAAPL--ASALLDHNRASVKGWV 1882
            :.|..:::. :.:||..|.|||    ..|.:||..|.:...|..|.|  |.||:...||:....|
Mouse   530 QYLQDLATN-EVTTTSLDSASR----FGLPSLGGRRRATPRSPGAELQAAGALMWGVRAAPGARV 589

  Fly  1883 QASID-SGP-------IMGIA 1895
            .|..: |||       ::||:
Mouse   590 AAGAETSGPEDAEVPCLLGIS 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	Rap_GAP	1648..1820	CDD:280332	43/182 (24%)
Sipa1	NP_001157952.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85		8/49 (16%)
		PHA03378	<29..>112	CDD:223065	16/76 (21%)
		Rap_GAP	347..528	CDD:396632	42/180 (23%)
		PDZ	683..755	CDD:395476
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	831..850
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	856..899
		Smc	<901..>1023	CDD:224117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..970
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810