DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5521 and sipa-1

DIOPT Version :9

Sequence 1:	NP_001163748.1	Gene:	CG5521 / 43242	FlyBaseID:	FBgn0039466	Length:	1964	Species:	Drosophila melanogaster
Sequence 2:	NP_001256347.1	Gene:	sipa-1 / 179596	WormBaseID:	WBGene00012100	Length:	997	Species:	Caenorhabditis elegans

Alignment Length:	758	Identity:	148/758 - (19%)
Similarity:	252/758 - (33%)	Gaps:	244/758 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1293 TSETIQKCITAIKLCAKAVSMHLVTHIGHFPMGIGASRLSSMVEEQDDIGNAAYGGQVETRRDSV 1357
            |:.:::.......||      |   |:.|.|:.:..|          ..|:...||.:: ...|.
Worm     4 TTSSVRSANRTRSLC------H---HLHHQPLLVSGS----------STGSPPIGGSMD-EGSSA 48

  Fly  1358 ELPSVVSAQNMQLFMLNSGLVASFIE-------LPTLKLPGGGI--------TAGLVTADK---- 1403
            ...|..:|:.:.:|.....::|..|.       ||    |..|:        ::|:::||:
Worm    49 STSSSATARALDMFNRRGSVLAVVIAGNTAADVLP----PSAGVPNTSAVSSSSGVISADQPSST 109

  Fly  1404 -----------------QVRVLMRDLNGKACWDASILYSEPRNAEEPPKTTPKIQHSQPLDS--- 1448
                             ::......|:..|.|.   |...|...::.|....:.|.....||
Worm   110 NSDNDTETFNEWRPPFPRLSAYQDCLSLAAAWG---LGMHPNGLDDKPTGASQAQSPSEDDSGDG 171

  Fly  1449 MATSMVTHTPSPRHTLRHRPAGVLPLAK---DM----------------APDLDQLDDML-AYIG 1493
            ....::...|:.|:.|...|.....|::   ||                |.:...|:|:. .|:|
Worm   172 KFNELLASCPAFRNELGWEPTRRFALSRHTFDMAHTDAHECETWMREHSASEAGILEDVSNVYLG 236

  Fly  1494 HTSPECVAPTVSQLNAP-------------------------TASPLS--------GNQEAQAIS 1525
              ...|.|.....:..|                         ...|:|        ..:|:.:|.
Worm   237 --GRLCAARQPKTVIEPQDIGSYYYRHCFISKNHIEYLGMDDILGPISISMVREIVDRKESYSIY 299

  Fly  1526 VILNQRLLEQEFVTHSTQAPSPALRHASSNSSLQQPDQRSLHSTTA---SFDSLPTRTEMPFQYC 1587
            .:: .|:.:|:  |.....|..||.....:....:|..|.|.....   ||..|....:.|
Worm   300 RMI-VRISDQK--TIRVAVPEEALSTPEGSDRATRPLMRELLEIVCPKISFGILRPSIQSP---- 357

  Fly  1588 RLLFSHLGLAGWERRSRTHLLQRSEKLMRELRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNTS 1652
                                  |.|:|   :..:|.|.....:|:.::.....|..:..:..|..
Worm   358 ----------------------RVEEL---IMKIDEQPIYTRYKVGIMLCKNEQSTEEQMYNNEF 397

  Fly  1653 GSSTYEMFVSALGWEIDLETHNGFLGGLPRQG--CGATAPYYATPFLEVVYHVATRMP-SDSSEA 1714
            .:.:::.|:..||..:.|:....:.|||..:|  .|..:.|......|:::||:|.:| :.|:..
Worm   398 STPSFDEFLDFLGQRVTLKGFEAYKGGLDTRGDTTGTHSIYSEYQAHEIMFHVSTLLPFTPSNRQ 462

  Fly  1715 MLLKTRHLGNDEVHIVWSEHNRDYRRDILP-------TEFCDVLIVVYP----LRNGLFRVTVNR 1768
            .|.:.||:|||.|.||:.|..      .||       :.|..|.|:|..    ..|..:.|.|:|
Worm   463 QLSRKRHIGNDMVTIVFQEPG------ALPFSPITVRSHFQHVFIIVRVHNECSENVTYSVAVSR 521

  Fly  1769 KPEVPWFGPLANESVVSGAC-----------LATLIRAT---------AINASRTKRAALPLYQQ 1813
            ..:||.|||    .|..|||           |..:|.|.         |..|:||:|.||....:
Worm   522 SKDVPAFGP----PVPKGACFSKCAEFHDWLLTKIINAENAVHRSKKFATMAARTRREALRDLVE 582

  Fly  1814 FY--EERNRSLDSVSSRY-------KESTTFEDFASRIYNPMP--------LSTLGTLRESNASS 1861
            .|  ..:|.....::||:       ||.          :||.|        ||.|..:.:.:.:.
Worm   583 NYVGPHQNEGASKIASRFLGGSVKRKER----------HNPKPTNHVMRGALSWLVDVHDYSTNQ 637

  Fly  1862 SAA---------------PLASALLDHNRASVKGWVQASIDSG 1889
            ..:               |..:.|......|:.||  |:.|:|
Worm   638 RISCVLGVAQDWIVLLERPSGTVLFSTPTHSIIGW--ATSDTG 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	Rap_GAP	1648..1820	CDD:280332	57/207 (28%)
sipa-1	NP_001256347.1	Rap_GAP	393..573	CDD:366939	52/189 (28%)
		PDZ_signaling	720..794	CDD:238492
		DHR10	<939..997	CDD:376021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910