Protein Alignment CG5521 and hgap-1

DIOPT Version :10

• Sequence 1: NP_001163748.1
• Gene: CG5521 / 43242
• FlyBaseID: FBgn0039466
• Length: 1964
• Species: Drosophila melanogaster
• Sequence 2: NP_001368371.1
• Gene: hgap-1 / 171663
• WormBaseID: WBGene00021209
• Length: 1306
• Species: Caenorhabditis elegans
• Alignment Length: 1944
• Identity: 392/1944 - (20%)
• Similarity: 649/1944 - (33%)
• Gaps: 744/1944 - (38%)

  Fly     1 MFTKK-SHADVKKSTAKLQDSKKDSASRLRHLRMILDNVELEESKCLFETNYSHVYFILYDTFIQ 64
            ||.:| ..:||:.|.::..|..:|..||::||:::||.:...|.:.|.: .:|...|.|.|..:.
 Worm     1 MFARKGKSSDVQASISRFTDLNRDCVSRVKHLKILLDTLTTNEKRQLLD-EHSFETFHLVDELLL 64

  Fly    65 AEANLKQKELPFHIVHKAHREELDGSLWLLEKILCLLPELLARRWQCHSLSRIMAKLLHLGNSPK 129
            ......|.:...         |.:..||.||::|||.|||:...||.|::..::.|.::..|...
 Worm    65 VNDVSSQIDSAI---------EAESGLWTLEQVLCLAPELVGSGWQRHAIESLLKKAVYPKNLMA 120

  Fly   130 LRREGVRYFLLWYQTLGENAPGYVHAMYADLIPGLIVPQKGVVGPDTEFSASDFLTHPNMKADGG 194
            :|:..:|.||::||.||         :|....|.|
 Worm   121 VRKIAIRLFLVFYQCLG---------VYGKATPDL------------------------------ 146

  Fly   195 MASVFHDNAFSHPVQSSEVVALLP--PSSSEKSAPPDPRDGLEVLLNSMVHTAA----CLRWRDN 253
                  |..|.         .|||  |.:|.::|        |.:||....::.    |.|.|:.
 Worm   147 ------DRVFQ---------CLLPFFPLTSGENA--------EDVLNEYCQSSGAGDWCERLRNG 188

  Fly   254 ------RAQKDHRAFAFLLQRFMDVFLPVFSPNFDVSCSIYNPRLDLPVMRSINKKEE------- 305
                  .|.:..:..|.:||.::|.||..        |:....|::   .....|::|
 Worm   189 PIKSTASASQTSKERAQMLQVYLDKFLEY--------CTRETVRIE---WNDEGKRQECANFIIE 242

  Fly   306 -----VMASC--------VVVLINW-----------------VSRFTHERLLSHRLDCTLHIEDV 340
                 .|..|        |.|...|                 ::|:...|.:::....|.|....
 Worm   243 KVIKLYMGECFTDLETNGVDVFGGWEGADENGEPLDTADPVVIARYWLIRWINNIASATTHTTAG 307

  Fly   341 DQVRLHGYQQGLIV-RDVLYVNRENINFVHEVYRQAFLL-----NFTSKPQIEAIRTAIAVYRDW 399
            .|..|......||: |:.|:.:.:..|....:.|:|..|     |.|.|        .:.|...|
 Worm   308 GQPTLQTTHASLILYRNALFSSHKATNVALTLMREAMKLPLACSNVTHK--------VVNVLSAW 364

  Fly   400 MTGETPPPFLLEPNDDPPPPSNAGGTPRSQRLRTPSYVGAIAGSKDQLVVRAGRQNVLQVFVTNA 464
            :.....|||:..                          |.::..:..|::    .|:|..|..:.
 Worm   365 LLQYEIPPFVAS--------------------------GEVSIERCSLLL----SNILLGFFHSP 399

  Fly   465 ANVFLV-----NTANLNICFPTRSRSYRSTPLEEQTEICKKVLNVYRTMVMNTEMDTRTWEQLLM 524
               :|.     :::.::|.|...:.             ||::  |...:.:...:..:.|.:|:.
 Worm   400 ---YLAQCGERHSSAISIAFAILTS-------------CKQL--VSHRIQLPKPLPQKFWSELMA 446

  Fly   525 VLLQVTSIVLHQNQHTLPSGTNKSATLGGILGSAIFQTLI--VTWIRAHTKVPVNVLLWEKFLNV 587
            .|....|.:..|:.   ....|.||        |...|||  |..|:|..::.::..:|::..:|
 Worm   447 GLCTCASKICRQSD---AFSQNVSA--------AFTSTLISNVVVIKAVRRIEIDDEVWDEVHDV 500

  Fly   588 LQS---LTHREELIIEWNKTIQTLTRVFSRYTYGINLLDLPLDRVAESRAEKRRRIGSVWQGSGS 649
            ::.   :...|    :|...:.::||....:...|::.         ||.|..|:
 Worm   501 MKKGVWIPMAE----QWASIVNSVTRALILHLAHIDIF---------SREEALRK---------- 542

  Fly   650 NSAANGGSAASAAISQNRQRESLAESSSSRSEETSSQVPLPNHPRPHHQHTQSQGGTGHGTRPIP 714
                      :..:|||.:|:::..:........||:                   ||
 Worm   543 ----------ATEVSQNSRRQAIESAMMEDPRNDSSE-------------------TG------- 571

  Fly   715 LTPMLSRSYSEGSLASAARSSRIRRRRAATPKPKALQPSQLAENRINPQDLRRAMSLDSLARKGD 779
                                                                     ||::....
 Worm   572 ---------------------------------------------------------DSMSSSNT 579

  Fly   780 AEETDSYQEGDNESGAGSRSPSPTASSGIEGGSIKDAQLQIDASLDDANSGSYGSGSNSGSISGR 844
            ..|.:.:.:.|:.:.|
 Worm   580 IAEDNVFHDTDDITNA------------------------------------------------- 595

  Fly   845 RCIILGGSAEGWHPDSTSIM--WKRMLGALGDVNRIPKADLHAQVFMHLLEMT-QNLIKIKQNQG 906
                    ...|..|..:.:  |:|::..:.     |..:..|.|.:..:.:| :||:.:
 Worm   596 --------VTSWSGDKLAWLQTWRRVISLVD-----PYTNSSAHVAIDCMSLTIENLLLV----- 642

  Fly   907 ISTDNQNTQPMP-------PLVPPIGIVAPWCYGSLSLDRSFKKGKLWALQLLCSLAIQGAVNMQ 964
                  |..|:.       ..|||  |:.|.|..:||
 Worm   643 ------NLHPLAHWLACRLVTVPP--ILLPRCVPALS---------------------------- 671

  Fly   965 QLPLFYHALHQLLTGEDRDLIYAILKH---LEGPRLLSLLLPGHTLLLLDLVHASAILLTSLEVS 1026
                                  |||..   ...|.|||                :.|||..:.:.
 Worm   672 ----------------------AILNESTIRRPPPLLS----------------ANILLCFIRLM 698

  Fly  1027 RSTPRAEVAALLGSLLCYPSSLLTRSVLQPTPQKFELMECSDLQDHILNIVLRCARREPSAKARC 1091
            :|..:..|.|:.| |..:..|::....|:..|:                 :|:.|:.....|.
 Worm   699 QSKEQLVVPAICG-LSAHELSIVAPRALEHLPK-----------------MLQAAKSSKDTKV-- 743

  Fly  1092 IALSQLGQWLLMRLSQPLPASNSGRANLFQQAVPHHKDVHPKASSVYNPRIKEVLQVLLQALQFK 1156
                               :|||  ..||...          |||.  |..:::|  |.|.:...
 Worm   744 -------------------SSNS--LKLFSML----------ASSY--PGAEQIL--LDQLVNTD 773

  Fly  1157 HHTIAIVAVDSLKLCAERGRQLAAIERVPQLIITAICKALEIQSVTKPKDSDKVVLTSLMLCLGE 1221
            ....|:|.|:||.:...:..|:       .|::||: |.:|.....             |..:..
 Worm   774 VSENAVVIVNSLAILIVQKAQI-------DLVLTAL-KTIETHQFA-------------MRLIPL 817

  Fly  1222 FCMAIPAPIMLTPFNEQGDTLVLQVLRVLLQVASGAPRHERVKLTADDDFDMHIAHDDLQGDGRL 1286
            ||.:|.:   |..|:   .|.:||   .||:.|| ..|.||.:
 Worm   818 FCSSIAS---LAQFS---STTLLQ---ALLRAAS-LLRDERTR---------------------- 850

  Fly  1287 PEATYQTSETIQKCITAIKLCAK--AVSMHLVTHIGHFPMGIGASRLSSMVEEQDDIGNAAYGGQ 1349
            .|..:|          .:|||.:  ...|.||..      ||.|.|  .||...:.:   ..|||
 Worm   851 TEIEWQ----------MVKLCMQWPQPQMPLVIR------GILADR--HMVLHGELV---TLGGQ 894

  Fly  1350 VETRRDSVELPSVVSAQNMQ-----LFMLNSGLVASFIELPTLKLPGGGITAGLVTADKQVRVLM 1409
            ...|...|:..|...|..:|     :::.....:.|             ::.....|.....:..
 Worm   895 YPVRGFEVQRWSSAGAPPLQGEDKTVYINRQSAIIS-------------VSRKDFHAKSPCEITS 946

  Fly  1410 RDLNGKACWDASILYSEPRNAEEPPKTTPKIQHSQPLDSMATSMVTHTPSPRHTLRHRPA----G 1470
            |.:.|:..||                    :...:.:...||: ||:..........||.    |
 Worm   947 RTVVGRHIWD--------------------LDTHEDVRKPATN-VTNWLRKEALKGKRPGRESQG 990

  Fly  1471 VLPLAKDMAPDLDQLDDMLAYIGHTSPECVAPTVSQLNAPTASPLSGNQEAQAISVILNQRLLEQ 1535
            :|. |.|     |..||:..|    .|...:|          ||:.|  .||..|:|
 Worm   991 ILG-AMD-----DPFDDLPDY----PPSRGSP----------SPVDG--AAQFTSMI-------- 1025

  Fly  1536 EFVTHSTQAPSPALRHASSNSSLQQPDQRSLHSTTASFDSLPTRT-EMPFQYCRLLFSHLGLAGW 1599
                               .:|.:||  :.|.:::|:.|.||..| .......|.|.:.||..
 Worm  1026 -------------------ETSRRQP--QPLGTSSAAHDHLPAFTPNAKLLEWRSLSASLGFV-- 1067

  Fly  1600 ERRSRTHLLQRSEKLMRELRNVDLQKCRETHKMAVIYVAAGQEDKGSILRNT--SGSSTYEMFVS 1662
            ...|:.|     ....|:|:::|....||.||:|||||...|||:.|||.||  |.|:.::.|.|
 Worm  1068 PLVSQVH-----ANFPRDLKHLDQTSSREVHKVAVIYVGESQEDRASILSNTTASASAQFDSFTS 1127

  Fly  1663 ALGWEIDL-ETHNGFLGGLPRQGCGATAPYYATPFLEVVYHVATRMPSDSSEAMLLKTRHLGNDE 1726
            .||||:.: ..|:|:.||||.:   ..|||:|....||::||:|.:..|..:    |.:|:||||
 Worm  1128 ELGWEVKVGRGHDGYTGGLPVE---TRAPYFADAEAEVIFHVSTMLNGDVQQ----KWKHIGNDE 1185

  Fly  1727 VHIVWSEHNRD-YRRDILPTEFCDVLIVVYPLRNGLFRVTVNRKPEVPWFGPLANESVVSGACLA 1790
            ||:||:|:.|. |.|:.:.|:|||||||:..:.:.:.||.|:....:. ||||.:.::|:.:.|:
 Worm  1186 VHVVWTENTRKVYTRETIATKFCDVLIVLEQVGDKMVRVRVDTASALE-FGPLFDGALVTMSELS 1249

  Fly  1791 TLIRATAINASRTKRAALPLYQQFYEERNRSLDSVSSRYKESTTFEDFASRIYNPMPLS 1849
            .|:|.|.|||||..|.|       ..|.:|.|     |::|. .|.:.|.....||||:
 Worm  1250 QLVRLTVINASRAYRLA-------RVEHSRPL-----RHREE-VFCNEALAHMKPMPLA 1295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5521	NP_001163748.1	RALGAPB_N	491..619	CDD:466561	24/132 (18%)
		Rap_GAP	1648..1820	CDD:460463	69/175 (39%)
hgap-1	NP_001368371.1	Rap_GAP	1111..1266	CDD:460463	67/162 (41%)