DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6330 and UPP2

DIOPT Version :9

Sequence 1:	NP_733175.1	Gene:	CG6330 / 43240	FlyBaseID:	FBgn0039464	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_001128570.1	Gene:	UPP2 / 151531	HGNCID:	23061	Length:	374	Species:	Homo sapiens

Alignment Length:	333	Identity:	163/333 - (48%)
Similarity:	228/333 - (68%)	Gaps:	12/333 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TITDNQTHDFKAHYDCAHRSSLQDDETDDAYV-KRITRYSDGTVKLRNSNIELMDQDILYHLALG 67
            |:|.:......:....::||...|..|   || ||.       |.::|..::|||:||||||.||
Human    49 TVTFHIVERMASVIPASNRSMRSDRNT---YVGKRF-------VHVKNPYLDLMDEDILYHLDLG 103

  Fly    68 SESHDLQEMFGDVKFVCMGGTPKRMENFAHFIMNEIGYKLPAGTQLQDISAYSYRYSMYKVGPVL 132
            :::|:|..|||||||||:||:|.||:.||.|:..|:|:: .|...::||.|.:.||.|||.||||
Human   104 TKTHNLPAMFGDVKFVCVGGSPNRMKAFALFMHKELGFE-EAEEDIKDICAGTDRYCMYKTGPVL 167

  Fly   133 CVSHGMGTPSVSILMHEMIKLMYHAKCKDPVFIRIGTCGGIGVDGGTVIITEDALDGQLRNSHEF 197
            .:|||||.||:||::||:|||::||:|.|...|||||.||||:..|||:||:.|:|...:...|.
Human   168 AISHGMGIPSISIMLHELIKLLHHARCCDVTIIRIGTSGGIGIAPGTVVITDIAVDSFFKPRFEQ 232

  Fly   198 TILGKTIHRPAKLDKKLARELKSLASPDDPYDTIIGKTLCTNDFYEGQGRLDGAFCDFSENEKMA 262
            .||...:.|..:|||:|:.||.:.:.....:.|::|.|:||.||||||||||||.|.||..:|:.
Human   233 VILDNIVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGRLDGALCSFSREKKLD 297

  Fly   263 YLEKLRENGVVNIEMESTIFAALTHHAGIKAAVVCVALLNRLNGDQVNAPKEVMNEWQARPQILV 327
            ||::..:.||.|||||||:|||:....|:|||||||.||:||:.||:|.|.:|:.|:|.|||:|:
Human   298 YLKRAFKAGVRNIEMESTVFAAMCGLCGLKAAVVCVTLLDRLDCDQINLPHDVLVEYQQRPQLLI 362

  Fly   328 SRYIRKVL 335
            |.:||:.|
Human   363 SNFIRRRL 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6330	NP_733175.1	PNP_UDP_1	50..337	CDD:294213	152/286 (53%)
UPP2	NP_001128570.1	PNP_UDP_1	86..371	CDD:294213	152/286 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1869
eggNOG	1	0.900	-	-		E1_COG2820
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12654
Inparanoid	1	1.050	313	1.000	Inparanoid score	I2574
Isobase	1	0.950	-	0	Normalized mean entropy	S3783
OMA	1	1.010	-	-		QHG59199
OrthoDB	1	1.010	-	-		D1423938at2759
OrthoFinder	1	1.000	-	-		FOG0002165
OrthoInspector	1	1.000	-	-		mtm8576
orthoMCL	1	0.900	-	-		OOG6_101919
Panther	1	1.100	-	-	LDO	PTHR43691
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3955
SonicParanoid	1	1.000	-	-		X2157
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.860