DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spag1 and TOMM70

DIOPT Version :9

Sequence 1:NP_651514.1 Gene:Spag1 / 43239 FlyBaseID:FBgn0039463 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_055635.3 Gene:TOMM70 / 9868 HGNCID:11985 Length:608 Species:Homo sapiens


Alignment Length:295 Identity:74/295 - (25%)
Similarity:127/295 - (43%) Gaps:66/295 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   219 NLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYNCSIIYDP-ENAVHA---YNNRAVAHLKLKK 279
            :::.|::.|.|:.   :||:.|||.:||.||:.|..:|...| |..|..   |.|||.|..:|:|
Human   107 DMNSLDRAQAAKN---KGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQK 168

  Fly   280 YFSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKLLD----------FEPDNAIA 334
            :.....||...::::|..:||..|.|:||       |.|:..|:.|:          |:  |..:
Human   169 WKEVAQDCTKAVELNPKYVKALFRRAKAH-------EKLDNKKECLEDVTAVCILEGFQ--NQQS 224

  Fly   335 KKAVEKLTSMLGE------------VAP---------SSATRLIIEEIDPPQLKTSEPKKEAEK- 377
            ....:|:..:||:            :.|         ||.|..||.:   |.||..:..::.:| 
Human   225 MLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQ---PMLKGEKSDEDKDKE 286

  Fly   378 SEPTVVKKPEPVVSAKKPPPIKDYD--LAELVKP-----NRMVKSNLVSAAEAL--GNKMQASKG 433
            .|...||:....:.||:....::||  ::|..|.     ..|.::.|:.|...|  ||      .
Human   287 GEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGN------A 345

  Fly   434 GAPKKPQSPPMTPKETLLRLPQDNLNNSNKLLIQE 468
            .|.|......::.||..::|..:.|.....:.:|:
Human   346 NAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQ 380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spag1NP_651514.1 TPR_11 229..295 CDD:290150 24/69 (35%)
TPR repeat 229..257 CDD:276809 11/27 (41%)
TPR repeat 262..293 CDD:276809 10/33 (30%)
TPR_11 266..329 CDD:290150 21/75 (28%)
TPR 266..297 CDD:197478 10/33 (30%)
TPR repeat 298..326 CDD:276809 9/27 (33%)
TOMM70NP_055635.3 3a0801s09 41..601 CDD:273380 74/295 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 67..107 74/295 (25%)
TPR 1 114..147 14/35 (40%)
TPR repeat 114..142 CDD:276809 12/30 (40%)
TPR repeat 152..182 CDD:276809 9/29 (31%)
TPR 2 153..186 10/32 (31%)
TPR 3 294..327 6/32 (19%)
TPR 4 329..362 9/38 (24%)
TPR repeat 329..357 CDD:276809 7/33 (21%)
TPR repeat 362..396 CDD:276809 3/19 (16%)
TPR 5 367..400 2/14 (14%)
TPR 6 401..434
TPR repeat 401..429 CDD:276809
TPR repeat 435..470 CDD:276809
TPR 7 440..475
TPR 8 476..509
TPR repeat 476..504 CDD:276809
TPR repeat 509..540 CDD:276809
TPR 9 511..544
TPR 10 545..578
TPR repeat 545..572 CDD:276809
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1535
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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