DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and TOM70

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_014278.3	Gene:	TOM70 / 855602	SGDID:	S000005065	Length:	617	Species:	Saccharomyces cerevisiae

Alignment Length:	382	Identity:	86/382 - (22%)
Similarity:	144/382 - (37%)	Gaps:	108/382 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 NELKKVKQNLNLPSVRKLSKIDLEKESKTEKPKPAPKATSPSNTKNKEARIKSTDYRKWDKYDPD 169
            |:|::.:|.....::.|..|.| .|:|:.| .:.|.|:|:|||
Yeast    30 NQLQQQQQRGKKNTINKDEKKD-TKDSQKE-TEGAKKSTAPSN---------------------- 70

  Fly   170 EEILRMDLNEERDQEQREKIISNHSKSVTTDKLQSERDSLYERLQAQLKNLSQLEKEQFAERHRL 234
            ..|..:..|.|.|       .||.:                        |.:..||:::|...:.
Yeast    71 PPIYPVSSNGEPD-------FSNKA------------------------NFTAEEKDKYALALKD 104

  Fly   235 RGNESFKAKEYENAIEEYNCSIIY--DPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMN 297
            :||:.|:.|:|::||:.||.::..  ||.    .|:|.:..::.:......:......|::.|..
Yeast   105 KGNQFFRNKKYDDAIKYYNWALELKEDPV----FYSNLSACYVSVGDLKKVVEMSTKALELKPDY 165

  Fly   298 IKAHLRMAEAHNAEGKHLES---LNVYKKLLDF-----EP--DNAIAKKAVEKLTSMLGEVAPSS 352
            .|..||.|.|:...||..::   |:|.....||     ||  :..:.|:|:.||....|::..::
Yeast   166 SKVLLRRASANEGLGKFADAMFDLSVLSLNGDFNDASIEPMLERNLNKQAMSKLKEKFGDIDTAT 230

  Fly   353 ATRLIIEEIDPPQLKTSEPKKEAEKSE--PTV--------VKKPEPVVSAKKPPPIKDYDLAELV 407
            ||        |.:|.|...|:..:|.|  |:|        :.|||...:        :||
Yeast   231 AT--------PTELSTQPAKERKDKQENLPSVTSMASFFGIFKPELTFA--------NYD----- 274

  Fly   408 KPNRMVKSNLVSAAEALGNKMQASKGGAPKKPQSPPMTPKETLLRLPQDNLNNSNKL 464
            :.|...|..:    ..|.|..:.|.....|..:|  .|....|.....|..|...||
Yeast   275 ESNEADKELM----NGLSNLYKRSPESYDKADES--FTKAARLFEEQLDKNNEDEKL 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	15/67 (22%)
		TPR repeat	229..257	CDD:276809	10/27 (37%)
		TPR repeat	262..293	CDD:276809	3/30 (10%)
		TPR_11	266..329	CDD:290150	15/70 (21%)
		TPR	266..297	CDD:197478	4/30 (13%)
		TPR repeat	298..326	CDD:276809	9/30 (30%)
TOM70	NP_014278.3	3a0801s09	1..614	CDD:273380	86/382 (23%)
		TPR repeat	99..127	CDD:276809	10/27 (37%)
		TPR repeat	131..161	CDD:276809	5/33 (15%)
		TPR repeat	166..189	CDD:276809	7/22 (32%)
		TPR repeat	330..358	CDD:276809
		TPR repeat	363..391	CDD:276809
		TPR repeat	396..426	CDD:276809
		TPR repeat	431..459	CDD:276809
		TPR repeat	465..493	CDD:276809
		TPR repeat	498..537	CDD:276809
		TPR repeat	542..567	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345411
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1535
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.830