Protein Alignment Spag1 and SWA2

DIOPT Version :10

• Sequence 1: NP_651514.1
• Gene: Spag1 / 43239
• FlyBaseID: FBgn0039463
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_010606.1
• Gene: SWA2 / 851918
• SGDID: S000002728
• Length: 668
• Species: Saccharomyces cerevisiae
• Alignment Length: 481
• Identity: 100/481 - (20%)
• Similarity: 168/481 - (34%)
• Gaps: 140/481 - (29%)

  Fly    25 VEKCTNARE----MEKIVQILRSGEEGHYPDLQRCAEEKLKALK---------PDSKLFRYEEQI 76
            :|:.|...|    .|:.::||:|.::.......|..|..:|..|         ..:.||
Yeast   157 IEEATEFYENDVTYERYLEILKSKQKERNDLAIRKKESGIKMEKSGLSNIVGTDSNNLF------ 215

  Fly    77 KQSTDLDKTELKPILDWTDAIKTKDNALNELKKVK---QNLNLPSVR-KLSKIDLEKESKTEKPK 137
            ..:||......|.:..||......::.||...|..   ::.:||.|. ..::|..|.....|...
Yeast   216 SMATDFFNKGKKLVDQWTSFPPEANDRLNNYSKTHDKVEDYDLPQVNDSPNRILFEDNEVVENLP 280

  Fly   138 PAPKATSPSNTKNKEARIKSTDYRKWDKYDPDEEILRMDLNEERDQEQREKIISNHSKSVTTDKL 202
            ||.                          :||:::| .|...:.|..:|.....:||.|.|:..|
Yeast   281 PAD--------------------------NPDQDLL-TDFETKIDITKRTAPDVSHSSSPTSGIL 318

  Fly   203 QSE---------RDSLYERLQAQLKN---------------------LSQLEKEQFAERHRLRGN 237
            ..|         .|||.:..:..|.|                     :|.:|...:.| .:.:|.
Yeast   319 IEENSRRNEPLIEDSLLDFSEGNLTNSKSNEDSTLFNENSNTDSTIPISDIELSGYNE-FKAKGT 382

  Fly   238 ESFKAKEYENAIEEYNCSIIYDPEN---AVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMN-- 297
            ..||..:|.|:::||..|:...|.|   .:.|.:|...:.||:.:|..:|.:....|::.|.:
Yeast   383 SLFKNGDYINSLQEYEKSLNTLPLNHPLRIIALSNIIASQLKIGEYSKSIENSSMALELFPSSKA 447

  Fly   298 -------------------IKAHLRMAEAHNAEGKHLES----LNVYKKLL--DFEPDNAIAKKA 337
                               .|..:|.||:.    :||||    |..|::|:  :|..|..:..|
Yeast   448 KWKNKISNSDPERSFNDIWPKIMIRRAESF----EHLESFKKALETYQELIKKNFFDDKIMQGK- 507

  Fly   338 VEKLTSMLGEVAPSSATRLIIEEIDPPQLKTSEPKKEAEKSEPTVVKKPEPVVSAKKPPPIKDYD 402
                             |...:.|:||.:|.|.|.|:...:.....||.....|:...|...|
Yeast   508 -----------------RRCQDFINPPPVKKSMPVKKKTTTTSPATKKQNLTASSSNSPISVD-- 553

  Fly   403 LAELVKPNRMVKSNLVSAAEALGNKM 428
                 ..:.:.|..|.:|..||.:|:
Yeast   554 -----STSEIKKRELENAKLALYDKV 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	NlpI	<229..373	CDD:443815	40/173 (23%)
		TPR repeat	229..257	CDD:276809	9/27 (33%)
		TPR repeat	262..293	CDD:276809	8/33 (24%)
		TPR repeat	298..326	CDD:276809	11/33 (33%)
SWA2	NP_010606.1	Ubiq-assoc	138..181	CDD:401184	7/23 (30%)
		TPR repeat	374..402	CDD:276809	9/28 (32%)
		CpoB	383..496	CDD:441335	28/116 (24%)
		TPR repeat	407..441	CDD:276809	8/33 (24%)
		TPR repeat	467..495	CDD:276809	11/31 (35%)