DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and SWA2

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_010606.1	Gene:	SWA2 / 851918	SGDID:	S000002728	Length:	668	Species:	Saccharomyces cerevisiae

Alignment Length:	481	Identity:	100/481 - (20%)
Similarity:	168/481 - (34%)	Gaps:	140/481 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VEKCTNARE----MEKIVQILRSGEEGHYPDLQRCAEEKLKALK---------PDSKLFRYEEQI 76
            :|:.|...|    .|:.::||:|.::.......|..|..:|..|         ..:.||
Yeast   157 IEEATEFYENDVTYERYLEILKSKQKERNDLAIRKKESGIKMEKSGLSNIVGTDSNNLF------ 215

  Fly    77 KQSTDLDKTELKPILDWTDAIKTKDNALNELKKVK---QNLNLPSVR-KLSKIDLEKESKTEKPK 137
            ..:||......|.:..||......::.||...|..   ::.:||.|. ..::|..|.....|...
Yeast   216 SMATDFFNKGKKLVDQWTSFPPEANDRLNNYSKTHDKVEDYDLPQVNDSPNRILFEDNEVVENLP 280

  Fly   138 PAPKATSPSNTKNKEARIKSTDYRKWDKYDPDEEILRMDLNEERDQEQREKIISNHSKSVTTDKL 202
            ||.                          :||:::| .|...:.|..:|.....:||.|.|:..|
Yeast   281 PAD--------------------------NPDQDLL-TDFETKIDITKRTAPDVSHSSSPTSGIL 318

  Fly   203 QSE---------RDSLYERLQAQLKN---------------------LSQLEKEQFAERHRLRGN 237
            ..|         .|||.:..:..|.|                     :|.:|...:.| .:.:|.
Yeast   319 IEENSRRNEPLIEDSLLDFSEGNLTNSKSNEDSTLFNENSNTDSTIPISDIELSGYNE-FKAKGT 382

  Fly   238 ESFKAKEYENAIEEYNCSIIYDPEN---AVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMN-- 297
            ..||..:|.|:::||..|:...|.|   .:.|.:|...:.||:.:|..:|.:....|::.|.:
Yeast   383 SLFKNGDYINSLQEYEKSLNTLPLNHPLRIIALSNIIASQLKIGEYSKSIENSSMALELFPSSKA 447

  Fly   298 -------------------IKAHLRMAEAHNAEGKHLES----LNVYKKLL--DFEPDNAIAKKA 337
                               .|..:|.||:.    :||||    |..|::|:  :|..|..:..|
Yeast   448 KWKNKISNSDPERSFNDIWPKIMIRRAESF----EHLESFKKALETYQELIKKNFFDDKIMQGK- 507

  Fly   338 VEKLTSMLGEVAPSSATRLIIEEIDPPQLKTSEPKKEAEKSEPTVVKKPEPVVSAKKPPPIKDYD 402
                             |...:.|:||.:|.|.|.|:...:.....||.....|:...|...|
Yeast   508 -----------------RRCQDFINPPPVKKSMPVKKKTTTTSPATKKQNLTASSSNSPISVD-- 553

  Fly   403 LAELVKPNRMVKSNLVSAAEALGNKM 428
                 ..:.:.|..|.:|..||.:|:
Yeast   554 -----STSEIKKRELENAKLALYDKV 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	18/68 (26%)
		TPR repeat	229..257	CDD:276809	9/27 (33%)
		TPR repeat	262..293	CDD:276809	8/33 (24%)
		TPR_11	266..329	CDD:290150	20/89 (22%)
		TPR	266..297	CDD:197478	8/30 (27%)
		TPR repeat	298..326	CDD:276809	11/33 (33%)
SWA2	NP_010606.1	Ubiq-assoc	138..181	CDD:401184	7/23 (30%)
		TPR	<374..497	CDD:223533	30/127 (24%)
		TPR repeat	374..402	CDD:276809	9/28 (32%)
		TPR repeat	407..441	CDD:276809	8/33 (24%)
		TPR repeat	467..495	CDD:276809	11/31 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860