DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and LONRF3

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_005262533.1	Gene:	LONRF3 / 79836	HGNCID:	21152	Length:	811	Species:	Homo sapiens

Alignment Length:	469	Identity:	100/469 - (21%)
Similarity:	173/469 - (36%)	Gaps:	123/469 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 EEQIKQSTDLDKTELKPILDWTDAIKTKD---NALNELKKV--KQNLNLPSVRKLSKIDLEKESK 132
            |.:.:||......|.|.:|...||:.::.   .||...:::  :|.|....:.:|.:...||..:
Human    53 EPEQEQSPGTSTPESKVLLTQADALASRGRIREALEVYRQLSERQQLVAEQLEQLVRCLAEKVPQ 117

  Fly   133 TEKPKPAP--KATSPSNTKNKE-----ARIKSTDYRKWDKY----------DP-----DEEILRM 175
            .|...|||  :.::.|.|...|     |...:|:.  ||.:          ||     .....::
Human   118 GEALAPAPPDEGSTASGTVAAEETGAAAAAAATEV--WDGFKCRKCHGFLSDPVSLSCGHTFCKL 180

  Fly   176 DLNEERDQEQREKI--ISNHSKSVTTDKLQSERDSLYE-----RLQAQLKNL-----------SQ 222
            .|...|..::|..:  :...:..|.|.:.:..|.:..:     |:...|..|           ||
Human   181 CLERGRAADRRCALCGVKLSALMVATGRARGARRAGQQPPPPLRVNVVLSGLLGKLFPGPARASQ 245

  Fly   223 LEKEQFAERHRLRGNESFKAKEYENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDC 287
            |..|         ||..::.::.|.|:.:||.::...|.:.: .|:||:..:..|:.:.:|:.|.
Human   246 LRHE---------GNRLYRERQVEAALLKYNEAVKLAPNDHL-LYSNRSQIYFTLESHENALHDA 300

  Fly   288 QACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVY------------------KKLLDF------- 327
            :...::.||..|||.|.|:|....||..|:|..:                  :.||.|
Human   301 EIACKLRPMGFKAHFRKAQALATLGKVEEALREFLYCVSLDGKNKRARCEAQRLLLSFFSPSVPG 365

  Fly   328 -----EPDNAIAK------KAVEKLTSMLGEVAPSSATRLIIEEIDPPQLKTSEPKKEAEKSEPT 381
                 .||  |.|      :..|.:.||..||...:..||:.:.::.|...:.|  :.|.:.:.:
Human   366 DSQEHSPD--ILKLLAPHPRLKENVESMTTEVTSHNLPRLLQDNLELPHCSSQE--EAAARGDGS 426

  Fly   382 VVKKPEPVVSAKKPPPIKDYDLAE----LVKPNRMVKSNLVSAAEALGNKMQASK---------- 432
            .:..|..|....:...:||.:..|    ...|         .||.:...|.|..|
Human   427 SLMDPAKVKGDGQQHHMKDQEEEEEKWDATSP---------KAASSKTGKCQEKKRKHCQIESQE 482

  Fly   433 -GGAPKK--PQSPP 443
             .|.|.|  .|.||
Human   483 ETGMPNKASKQDPP 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	13/65 (20%)
		TPR repeat	229..257	CDD:276809	6/27 (22%)
		TPR repeat	262..293	CDD:276809	6/30 (20%)
		TPR_11	266..329	CDD:290150	21/92 (23%)
		TPR	266..297	CDD:197478	7/30 (23%)
		TPR repeat	298..326	CDD:276809	11/45 (24%)
LONRF3	XP_005262533.1	RING	158..195	CDD:302633	5/36 (14%)
		TPR_11	242..308	CDD:290150	17/75 (23%)
		TPR repeat	243..271	CDD:276809	10/36 (28%)
		TPR repeat	276..306	CDD:276809	6/30 (20%)
		TPR repeat	311..334	CDD:276809	10/22 (45%)
		RING	518..557	CDD:238093
		LON_substr_bdg	607..808	CDD:280370
		LON	618..796	CDD:271862
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810