DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and ifit14

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001287802.1	Gene:	ifit14 / 794786	ZFINID:	ZDB-GENE-131120-20	Length:	433	Species:	Danio rerio

Alignment Length:	285	Identity:	55/285 - (19%)
Similarity:	97/285 - (34%)	Gaps:	120/285 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 RKWDKYDPDE-----------EILRMDLNEERDQ----EQREKIISNHSKSVTTDKLQSERDSL- 209
            ||.|..||.:           ..::..|..:|:.    ::.|.:|.......|..:|...:.:|
Zfish    32 RKMDHVDPQKISSPVHYYNLLGFIQKSLGSDREALESLQKAESVIQEQGTEETAVRLLVNKANLA 96

  Fly   210 --------YERLQAQLKNLSQLEK------------EQFAER--HRLRGNESFKAKEYENAIEEY 252
                    .|:.:..|:.|.:|::            |...|:  ..::.|:|.|::    ||..:
Zfish    97 WVYFYLGELEKSRGYLEELEELQRIHPAPPGCPLHPEVSGEKGWTLVKFNKSKKSQ----AIGYF 157

  Fly   253 NCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACL--------------------QIDPMN 297
            ..::..:||        |...|..|     |||..:|||                    :|||.:
Zfish   158 KMALEAEPE--------RKEWHKGL-----AISMSKACLWYKCTPEQKAEILEKVKTAAEIDPND 209

  Fly   298 IKAHLRMAEAHNAEGKHLESLNVYKKL------LDFEPDNAIAK--------------------- 335
            :               .|:||.|.||.      :|.|..:.:.|
Zfish   210 L---------------FLQSLYVLKKFEVQGENVDEEIQSLLKKSISTANLVGLNYIIEYFKGIS 259

  Fly   336 --KAVEKLTSMLGEVAPSSATRLII 358
              :|:|:: ..:.|:.|||:|.|.|
Zfish   260 YGRAIEEV-QRVREIFPSSSTLLKI 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	18/87 (21%)
		TPR repeat	229..257	CDD:276809	6/29 (21%)
		TPR repeat	262..293	CDD:276809	9/50 (18%)
		TPR_11	266..329	CDD:290150	19/88 (22%)
		TPR	266..297	CDD:197478	12/50 (24%)
		TPR repeat	298..326	CDD:276809	6/33 (18%)
ifit14	NP_001287802.1	TPR_12	47..120	CDD:290160	11/72 (15%)
		TPR repeat	248..272	CDD:276809	2/24 (8%)
		TPR repeat	277..319	CDD:276809	4/7 (57%)
		TPR repeat	324..352	CDD:276809
		TPR repeat	358..392	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900