DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and bbs4

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001070934.2	Gene:	bbs4 / 768303	ZFINID:	ZDB-GENE-060126-2	Length:	528	Species:	Danio rerio

Alignment Length:	329	Identity:	69/329 - (20%)
Similarity:	122/329 - (37%)	Gaps:	98/329 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEKEKKKSLLERYN--IPIHYL--DFAHVEKCTNAREMEKIVQILRSGEEGHYPDLQRCAEEKLK 61
            ::|..:..:||:.|  |.:||:  |:   |.|      :.||:     |:.|  :.|...|   .
Zfish    23 LKKAPELPILEKRNWLIHLHYIRKDY---ETC------KAIVK-----EQLH--ETQGMCE---Y 68

  Fly    62 ALKPDSKLFRYEEQIKQSTDLDKTELKPILDWTDAIKTKDNALNELKKVKQNLNLPSVRKLSKID 126
            |:...:.:.|.|.:|::|.:|.::  ..|::.|    :.||    ||:|.::|.|....|
Zfish    69 AVYVQALIMRLEGKIQESLELFQS--CAIINPT----SSDN----LKQVARSLFLLGKHK----- 118

  Fly   127 LEKESKTEKPKPAPKATSPSNTKNKEARIKSTDYRKWDKYDPDEEILRMDLNEERDQEQREKIIS 191
                             :.....|:.||:...|   |:                          .
Zfish   119 -----------------AAIEVYNEAARLNQKD---WE--------------------------I 137

  Fly   192 NHSKSVT---TDKLQSERDSLYERLQAQLKNLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYN 253
            :|:..|.   |...:|..:.|...||....:|:.:   ...:.|.|:|       :.|.||:.|.
Zfish   138 SHNLGVCYIYTKDFRSAEEQLNLALQLNKHDLTYM---MLGKIHLLQG-------DTEKAIDVYK 192

  Fly   254 CSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLESL 318
            .::.:.||| ........:.:::|.||..|.......|..||.|.||.|.........|.:..::
Zfish   193 SAVEFSPEN-TELLTTLGLLYMQLGKYQKAFEHLGNALTYDPNNFKAILAAGSMMQTHGDYDVAM 256

  Fly   319 NVYK 322
            |.|:
Zfish   257 NKYR 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	15/65 (23%)
		TPR repeat	229..257	CDD:276809	7/27 (26%)
		TPR repeat	262..293	CDD:276809	6/30 (20%)
		TPR_11	266..329	CDD:290150	14/57 (25%)
		TPR	266..297	CDD:197478	7/30 (23%)
		TPR repeat	298..326	CDD:276809	6/25 (24%)
bbs4	NP_001070934.2	TPR repeat	68..95	CDD:276809	6/28 (21%)
		TPR_11	100..166	CDD:290150	20/120 (17%)
		TPR repeat	104..129	CDD:276809	7/46 (15%)
		TPR repeat	134..164	CDD:276809	8/58 (14%)
		TPR_11	169..233	CDD:290150	16/74 (22%)
		TPR repeat	169..196	CDD:276809	8/36 (22%)
		TPR repeat	202..229	CDD:276809	4/26 (15%)
		TPR_11	235..301	CDD:290150	7/26 (27%)
		TPR repeat	237..264	CDD:276809	6/24 (25%)
		TPR repeat	270..298	CDD:276809
		PH-like	<272..340	CDD:302622
		TPR_11	272..335	CDD:290150
		TPR repeat	303..333	CDD:276809
		TPR_11	305..369	CDD:290150
		TPR repeat	338..366	CDD:276809
		TPR repeat	372..397	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900