DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and spag1b

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001070789.1	Gene:	spag1b / 768178	ZFINID:	ZDB-GENE-061013-512	Length:	591	Species:	Danio rerio

Alignment Length:	372	Identity:	99/372 - (26%)
Similarity:	179/372 - (48%)	Gaps:	53/372 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NIPIHYLDFAHVEKCTNAREMEKIVQILRSGEEGHYPDLQRCAEEKLKALKPDSKLFRYEEQIKQ 78
            ::|:.:||::.::.|::.:::|:|:::||||:||.||.|....|.:::.|.|.|...|.|.....
Zfish    11 SVPVEHLDYSFIQSCSDLKQLEQILRVLRSGQEGVYPHLIGFCERRIEMLNPKSAELRTENHPHT 75

  Fly    79 STDLDKTELKPILD----WTDAIKTKDNALNELKKVKQNLNLPSVRKLSKI-DLEKESKTEKPKP 138
            :....:.|.:.|.:    |..:::..:.||...........:|.||...:: ...:|.||.|...
Zfish    76 AACYTEEEWRSITEDLQVWERSVRMTEAALMRSSIFSSEECVPPVRSSHRVLQTNQEKKTVKTSC 140

  Fly   139 APKATSPSNTKNKEARIKSTDYRKWDKYDPDEEILRMDLNEERDQEQREKIISNHSKSVTTDKLQ 203
            ||:                 .|..||::|.|...            ..|.:.:..:.:....::|
Zfish   141 APR-----------------PYTDWDRFDVDSAC------------AGESVRNAPAAAAVCPEVQ 176

  Fly   204 SERDSLYERLQAQLKNLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYNCSIIYDPENAVHAYN 268
             :|.|....|.||       ||:..|.|.:.:|||::::::||.|::.|..|:......||  :|
Zfish   177 -QRLSSCTALTAQ-------EKQTAALREKDKGNEAYRSRDYEEALDYYCRSLSLASSAAV--FN 231

  Fly   269 NRAVAHLKLKKYFSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKLLDFEPDNAI 333
            |||...::|:::.:|:|||.|.||::|.||||.||.|..|...|...||.:..:.:|..:|.|..
Zfish   232 NRAQTLIRLQQWPAALSDCDAVLQLEPHNIKALLRRATVHKHLGHQQESHDDLRAVLQIQPQNKT 296

  Fly   334 AKKAVEKLTSM-LGEVAPSSATRLIIEEIDPPQLKTSEPKKEAEKSE 379
            |.|.:..::|. ..:...|:..|::|:|:        |.::|...||
Zfish   297 ALKLLADVSSTDPPQQTRSTGRRILIQEV--------EEEEEGAHSE 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	24/65 (37%)
		TPR repeat	229..257	CDD:276809	10/27 (37%)
		TPR repeat	262..293	CDD:276809	13/30 (43%)
		TPR_11	266..329	CDD:290150	25/62 (40%)
		TPR	266..297	CDD:197478	13/30 (43%)
		TPR repeat	298..326	CDD:276809	10/27 (37%)
spag1b	NP_001070789.1	TPR_11	194..258	CDD:290150	24/65 (37%)
		TPR repeat	198..222	CDD:276809	8/23 (35%)
		TPR repeat	226..256	CDD:276809	13/31 (42%)
		TPR_16	233..294	CDD:290168	24/60 (40%)
		TPR repeat	261..289	CDD:276809	10/27 (37%)
		TPR repeat	483..513	CDD:276809
		TPR_11	486..548	CDD:290150
		TPR_1	486..517	CDD:278916
		TPR repeat	518..546	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	113	1.000	Inparanoid score	I4833
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1070087at2759
OrthoFinder	1	1.000	-	-		FOG0008026
OrthoInspector	1	1.000	-	-		otm26431
orthoMCL	1	0.900	-	-		OOG6_105718
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.770