Protein Alignment Spag1 and TTC1

DIOPT Version :10

• Sequence 1: NP_651514.1
• Gene: Spag1 / 43239
• FlyBaseID: FBgn0039463
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_003305.1
• Gene: TTC1 / 7265
• HGNCID: 12391
• Length: 292
• Species: Homo sapiens
• Alignment Length: 249
• Identity: 71/249 - (28%)
• Similarity: 110/249 - (44%)
• Gaps: 29/249 - (11%)

  Fly   112 QNLNLPS--VRKLSKIDLEKESKTEKPKPAPKATSPSNTK---NKEARIKSTDYRKWDKYDPDEE 171
            :|..:|.  :..|...|.::......|.|.|| ...|.:|   :.||.::.         |..||
Human     6 ENCGVPEDLLNGLKVTDTQEAECAGPPVPDPK-NQHSQSKLLRDDEAHLQE---------DQGEE 60

  Fly   172 ILRMDLNEERDQEQREKIISNHSKSVTTDKLQSERDSLYERLQAQLKNLSQLEKEQFAE---RHR 233
            ....|.:...::|.....:.|.|..   |...||.|..|  |....||:|..||::..|   |.:
Human    61 ECFHDCSASFEEEPGADKVENKSNE---DVNSSELDEEY--LIELEKNMSDEEKQKRREESTRLK 120

  Fly   234 LRGNESFKAKEYENAIEEYN-----CSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQI 293
            ..|||.||..:|..|...|:     |...:..|.:: .::|||.|.:|..|...||:||...:|:
Human   121 EEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSI-LFSNRAAARMKQDKKEMAINDCSKAIQL 184

  Fly   294 DPMNIKAHLRMAEAHNAEGKHLESLNVYKKLLDFEPDNAIAKKAVEKLTSMLGE 347
            :|..|:|.||.||.:....|..|:|..||.:|:.:|....|::|..:|...:.|
Human   185 NPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLPKQIEE 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	NlpI	<229..373	CDD:443815	41/127 (32%)
		TPR repeat	229..257	CDD:276809	11/35 (31%)
		TPR repeat	262..293	CDD:276809	10/30 (33%)
		TPR repeat	298..326	CDD:276809	11/27 (41%)
TTC1	NP_003305.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..125		29/116 (25%)
		NlpI	49..>221	CDD:443815	56/186 (30%)
		TPR 1	116..149		10/32 (31%)
		TPR repeat	119..144	CDD:276809	8/24 (33%)
		TPR repeat	149..184	CDD:276809	11/35 (31%)
		TPR 2	155..188		12/33 (36%)
		TPR 3	189..222		13/32 (41%)
		TPR repeat	189..217	CDD:276809	11/27 (41%)