DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spag1 and Dnaaf4

DIOPT Version :9

Sequence 1:NP_651514.1 Gene:Spag1 / 43239 FlyBaseID:FBgn0039463 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_080590.3 Gene:Dnaaf4 / 67685 MGIID:1914935 Length:420 Species:Mus musculus


Alignment Length:377 Identity:84/377 - (22%)
Similarity:157/377 - (41%) Gaps:79/377 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MEKEKKKSLLERYNIPIHYLDFAHVEKCTNAREMEKIVQILRSGEEGHYPDLQRCAEEKLKALKP 65
            |::.::||:|:..            ||...|.|.:.:.:  |..:.....::.:..||:.|.:: 
Mouse    96 MQRIREKSILQAQ------------EKAKEATEAKAVAK--REDQRYALGEMMKIEEEERKKIE- 145

  Fly    66 DSKLFRYEEQIKQSTDLDKTELKPILDWTDAIKTKDNALNELKKVKQNLNLPSVRKLSKIDLEKE 130
            |.|    |.:.|::|    :||:.   |.:..|..|......:|.|     |...|.:     :|
Mouse   146 DMK----ENERKKAT----SELEA---WKECQKKADGQKRVQRKEK-----PLEGKQA-----EE 189

  Fly   131 SKTEKPKPAPKATSPSNTKNKEARIKSTDYRKWDKYDPDEEILRMDLNEERDQEQRE-------- 187
            :|..||:..|:...|:..        .|..|.|:...|::      |.|:|....|.        
Mouse   190 TKALKPRGLPRKAPPTRL--------PTRGRNWENIFPEK------LKEDRVPAPRSAGSIQISF 240

  Fly   188 --KIISNHSKSVTTDKLQSERDSLYERLQAQLKNLSQL-------EKEQFAERHRLRGNESFKAK 243
              ::...   ::...::..|.:.|:::.:|:....:.|       |:|:..:..:.:||:.|..:
Mouse   241 TPRVFPT---ALRESQVAEEEEWLHKQAEARRAMSTDLPEFFDLKEEERNPDWLKDKGNKLFATE 302

  Fly   244 EYENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQI------DPMN--IKA 300
            .|..|::.||.:|..:.:..: .|.|||..|||||....||.|....|::      |..|  :||
Mouse   303 NYLAAVDAYNLAIRLNCKIPL-LYLNRAACHLKLKNLHKAIEDSSKALELLTPPVADNANARMKA 366

  Fly   301 HLRMAEAHNAEGKHLESLNVYKKLLDFEPDNAIAKKAVEKLTSMLGEVAPSS 352
            |:|...|......::|.|..|:..|..:|.|.:.:...||:.:::...|..|
Mouse   367 HVRRGTAFCQLELYVEGLQDYEAALKIDPANTVVQNDAEKIRNIIQGTALKS 418

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spag1NP_651514.1 TPR_11 229..295 CDD:290150 21/71 (30%)
TPR repeat 229..257 CDD:276809 7/27 (26%)
TPR repeat 262..293 CDD:276809 13/30 (43%)
TPR_11 266..329 CDD:290150 24/70 (34%)
TPR 266..297 CDD:197478 14/36 (39%)
TPR repeat 298..326 CDD:276809 8/27 (30%)
Dnaaf4NP_080590.3 Mediates interaction with ESR1 and STUB1. /evidence=ECO:0000250 7..103 1/6 (17%)
p23_DYX1C1_like 10..87 CDD:107226
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 164..212 13/65 (20%)
TPR_11 287..351 CDD:290150 21/64 (33%)
TPR 1 288..321 8/32 (25%)
TPR repeat 288..316 CDD:276809 7/27 (26%)
TPR repeat 321..351 CDD:276809 13/30 (43%)
TPR 2 322..355 13/33 (39%)
TPR_1 322..351 CDD:278916 13/29 (45%)
TPR_12 324..396 CDD:290160 24/71 (34%)
TPR repeat 362..392 CDD:276809 8/29 (28%)
TPR 3 364..397 10/32 (31%)
TPR_1 365..397 CDD:278916 10/31 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 62 1.000 Inparanoid score I5388
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.950

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