DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and Tomm34

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001278084.1	Gene:	Tomm34 / 67145	MGIID:	1914395	Length:	309	Species:	Mus musculus

Alignment Length:	337	Identity:	77/337 - (22%)
Similarity:	132/337 - (39%)	Gaps:	79/337 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 EKIVQILRSGEE----GHYPDLQRCAEEKLKALK------PDSKLFRYEEQ-------------I 76
            :.:.|:..:|.:    |.|.:.....|..|:.|:      |:.:...|..:             |
Mouse     7 DSVEQLRAAGNQNFRNGQYGEASALYERALRLLQARGSADPEEESVLYSNRAACYLKDGNCTDCI 71

  Fly    77 KQSTD---LDKTELKPILDWTDAIKTKDN---ALNELKKVKQNLN-----LPSVRKLSKIDLEKE 130
            |..|.   |....:||:|....|.:..:.   |..:.|.|.|..|     |..:.::::..::..
Mouse    72 KDCTSALALVPFSIKPLLRRASAYEALEKYALAYVDYKTVLQIDNSVASALEGINRITRALMDSL 136

  Fly   131 SKTEKPKPAPKATSPSNTKNKEARIKSTDYRKWDKYDPDEEILRMDLNEERDQEQREKIISNHSK 195
            ....:.|..|....|.:.:           ::|:....|               ..::.....||
Mouse   137 GPEWRLKLPPIPVVPVSAQ-----------KRWNSLPSD---------------NHKETAKTKSK 175

  Fly   196 SVTTDKLQSERDSLYERLQAQLKNLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYNCSIIYDP 260
            ..|..|.:.......||.:|       |::|         ||:..|...::.|||:|:.|::...
Mouse   176 EATATKSRVPSAGDVERAKA-------LKEE---------GNDLVKKGNHKKAIEKYSESLLCSS 224

  Fly   261 -ENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKL 324
             |:|  .|:|||:.||.||:|..|:.||...|::|..|:||..|.|:|:.|...:..||:....|
Mouse   225 LESA--TYSNRALCHLVLKQYKEAVKDCTEALKLDGKNVKAFYRRAQAYKALKDYKSSLSDISSL 287

  Fly   325 LDFEPDNAIAKK 336
            |..||.|..|:|
Mouse   288 LQIEPRNGPAQK 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	23/66 (35%)
		TPR repeat	229..257	CDD:276809	8/27 (30%)
		TPR repeat	262..293	CDD:276809	14/30 (47%)
		TPR_11	266..329	CDD:290150	25/62 (40%)
		TPR	266..297	CDD:197478	14/30 (47%)
		TPR repeat	298..326	CDD:276809	9/27 (33%)
Tomm34	NP_001278084.1	TPR 3	85..118		9/32 (28%)
		TPR repeat	85..113	CDD:276809	7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..189		6/45 (13%)
		TPR_11	192..257	CDD:290150	27/82 (33%)
		TPR 4	193..226		11/48 (23%)
		TPR repeat	193..221	CDD:276809	11/43 (26%)
		TPR repeat	226..256	CDD:276809	15/31 (48%)
		TPR 5	227..260		15/34 (44%)
		TPR_1	229..260	CDD:278916	14/30 (47%)
		TPR 6	261..294		12/32 (38%)
		TPR 1	9..42		7/32 (22%)
		TPR repeat	9..37	CDD:276809	5/27 (19%)
		TPR_11	10..82	CDD:290150	13/71 (18%)
		TPR_11	50..115	CDD:290150	13/64 (20%)
		TPR repeat	50..80	CDD:276809	4/29 (14%)
		TPR 2	51..84		5/32 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43674
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1535
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840