DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and Ifit1bl1

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001095075.1	Gene:	Ifit1bl1 / 667373	MGIID:	3650685	Length:	470	Species:	Mus musculus

Alignment Length:	334	Identity:	65/334 - (19%)
Similarity:	121/334 - (36%)	Gaps:	102/334 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKKKSLLERYNIPIHY-LDFAHVEKCTNAREMEKIVQILRSGEEGHYPDLQRCAEEKLKALKPDS 67
            :|.:.:.:.::.|..| |:.|.:: |      |:...:|:.|.: :|.....|..:.|| ::|::
Mouse   124 DKVEKVCKEFSSPFQYRLECAEMD-C------EEGWALLKCGIQ-NYKGAMACFAKALK-VEPEN 179

  Fly    68 KLFR--YEEQIKQSTDLDKTELKPILDWTDAIKTKDNALNELKKVKQNLNLPSVRKLSKIDLEKE 130
            ..:.  |.....:...:|.|.|:. |....::|.:|..|    ||...|.|..:.||.    |.|
Mouse   180 PEYNAGYAVVAYRLDHIDGTSLQH-LQKAVSVKPEDPYL----KVLLALKLQDLHKLE----EAE 235

  Fly   131 SKTEKPKPAPKATSPSNTKNKEARIKSTDY-----RKWDKYDPDEEILRMDLNEERDQEQREKII 190
            ...|:..|               ||.|..|     .|:                     .|.|.:
Mouse   236 KHIEETLP---------------RISSQPYVFGYVAKF---------------------YRRKGL 264

  Fly   191 SNHSKSVTTDKLQSERDSLYERLQAQL---KNLSQLEKEQFAERHRLRGNESFKAKEYENAIEEY 252
            ...:.......||.:..|.:...|..|   |.|.|::|   |...:.||.:..:|
Mouse   265 VKEALEFLGRALQKQPCSTFLHFQIGLCHKKRLIQIKK---ASNMQPRGEDRKRA---------- 316

  Fly   253 NCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLES 317
                    :.::|.    |:.|.|            ..|::.|..:.|::.:||.:..:.:..|:
Mouse   317 --------DQSIHL----AICHFK------------RTLELKPTYVMAYVTLAEMYIEKNQLKEA 357

  Fly   318 LNVYKKLLD 326
            .:.::|||:
Mouse   358 EDNFQKLLN 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	9/65 (14%)
		TPR repeat	229..257	CDD:276809	4/27 (15%)
		TPR repeat	262..293	CDD:276809	5/30 (17%)
		TPR_11	266..329	CDD:290150	12/61 (20%)
		TPR	266..297	CDD:197478	5/30 (17%)
		TPR repeat	298..326	CDD:276809	6/27 (22%)
Ifit1bl1	NP_001095075.1	TPR_12	62..132	CDD:290160	1/7 (14%)
		TPR repeat	63..94	CDD:276809
		TPR repeat	99..129	CDD:276809	1/4 (25%)
		TPR repeat	144..174	CDD:276809	7/37 (19%)
		TPR_16	153..215	CDD:290168	13/64 (20%)
		TPR repeat	179..210	CDD:276809	5/31 (16%)
		TPR repeat	215..242	CDD:276809	10/34 (29%)
		TPR repeat	249..277	CDD:276809	4/48 (8%)
		TPR repeat	282..333	CDD:276809	16/87 (18%)
		TPR_11	<323..368	CDD:290150	12/56 (21%)
		Capsule_synth	<330..>434	CDD:304472	9/37 (24%)
		TPR repeat	338..365	CDD:276809	5/26 (19%)
		TPR repeat	376..405	CDD:276809
		TPR repeat	430..461	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900