Protein Alignment Spag1 and SGTA

DIOPT Version :10

• Sequence 1: NP_651514.1
• Gene: Spag1 / 43239
• FlyBaseID: FBgn0039463
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_003012.1
• Gene: SGTA / 6449
• HGNCID: 10819
• Length: 313
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 71/257 - (27%)
• Similarity: 113/257 - (43%)
• Gaps: 58/257 - (22%)

  Fly   225 KEQFAERHRLR--GNESFKAKEYENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDC 287
            :|..||..||:  |||..|.:.:|.|:..|..:|..:|.|||: :.|||.|:.||..|..|:.||
Human    85 EEDSAEAERLKTEGNEQMKVENFEAAVHFYGKAIELNPANAVY-FCNRAAAYSKLGNYAGAVQDC 148

  Fly   288 QACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKLLDFEPDNAIAKKAVEKLTSMLGEVAPSS 352
            :..:.|||...||:.||..|.::..||:|::..|||.|:.:|||...|.
Human   149 ERAICIDPAYSKAYGRMGLALSSLNKHVEAVAYYKKALELDPDNETYKS---------------- 197

  Fly   353 ATRLIIEEIDPPQLKTSEPK-KEAEKSEPTVVKKPEPVVSAKKPPPIKDYDLAELV-KPNRM-VK 414
                        .||.:|.| :||          |.|...      :..:|:|.|: .|..| :.
Human   198 ------------NLKIAELKLREA----------PSPTGG------VGSFDIAGLLNNPGFMSMA 234

  Fly   415 SNLVSAAEALGNKMQASKGGAPKKPQSPPMTPKE----TLLRLPQ---DNLNNSNKLLIQEI 469
            |||::..: :...|.....|......:|..:|.:    :|::..|   ..:...|..||:::
Human   235 SNLMNNPQ-IQQLMSGMISGGNNPLGTPGTSPSQNDLASLIQAGQQFAQQMQQQNPELIEQL 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	NlpI	<229..373	CDD:443815	49/146 (34%)
		TPR repeat	229..257	CDD:276809	11/29 (38%)
		TPR repeat	262..293	CDD:276809	13/30 (43%)
		TPR repeat	298..326	CDD:276809	11/27 (41%)
SGTA	NP_003012.1	SGTA_dimer	5..64	CDD:465168
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..100		6/14 (43%)
		Spy	85..>199	CDD:443119	46/142 (32%)
		TPR 1	91..124		11/32 (34%)
		TPR repeat	91..119	CDD:276809	9/27 (33%)
		TPR repeat	124..154	CDD:276809	13/30 (43%)
		TPR 2	125..158		15/33 (45%)
		TPR 3	159..192		13/32 (41%)
		TPR repeat	159..187	CDD:276809	11/27 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..269		3/18 (17%)