DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and FKBPL

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_071393.2	Gene:	FKBPL / 63943	HGNCID:	13949	Length:	349	Species:	Homo sapiens

Alignment Length:	183	Identity:	50/183 - (27%)
Similarity:	71/183 - (38%)	Gaps:	23/183 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 EILRMDLNEERDQEQREKIISNHS---KSVTTDKLQSERDSLYERLQAQLKNLSQLEKEQFAERH 232
            |::...|......|:.|..:..||   ..:|.......|||.         .|...|||..|...
Human   158 ELIEKCLESMCQGEEAELQLPGHSGPPVRLTLASFTQGRDSW---------ELETSEKEALAREE 213

  Fly   233 RLRGNESFKAKEYENAIEEYNCSIIY--------DPENAV-HAYNNRAVAHLKLKKYFSAISDCQ 288
            |.||.|.|:|...|.|...|..::..        .||..| ||  |.|...|.|.:...|...|.
Human   214 RARGTELFRAGNPEGAARCYGRALRLLLTLPPPGPPERTVLHA--NLAACQLLLGQPQLAAQSCD 276

  Fly   289 ACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKLLDFEPDNAIAKKAVEKL 341
            ..|:.:|.::||..|...|..|.|...::....||:|..:|.|..|::.:.|:
Human   277 RVLEREPGHLKALYRRGVAQAALGNLEKATADLKKVLAIDPKNRAAQEELGKV 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	22/74 (30%)
		TPR repeat	229..257	CDD:276809	10/27 (37%)
		TPR repeat	262..293	CDD:276809	10/31 (32%)
		TPR_11	266..329	CDD:290150	18/62 (29%)
		TPR	266..297	CDD:197478	9/30 (30%)
		TPR repeat	298..326	CDD:276809	8/27 (30%)
FKBPL	NP_071393.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..55
		TPR_11	187..>348	CDD:330823	44/154 (29%)
		TPR 1	210..243		10/32 (31%)
		TPR repeat	210..238	CDD:276809	10/27 (37%)
		TPR repeat	251..281	CDD:276809	10/31 (32%)
		TPR 2	252..285		11/34 (32%)
		TPR 3	286..319		10/32 (31%)
		TPR repeat	286..314	CDD:276809	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810