DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and tomm70a

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_956296.1	Gene:	tomm70a / 572969	ZFINID:	ZDB-GENE-030131-8173	Length:	578	Species:	Danio rerio

Alignment Length:	370	Identity:	85/370 - (22%)
Similarity:	152/370 - (41%)	Gaps:	99/370 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 NEERDQEQREKIISNHSKSVTTDKLQSERDSLYERLQAQLKNLSQLEKEQFAERHRLRGNESFKA 242
            |..|.:|::.|   .:.:..|.:...|.....:.....:|:|||.|::.|.|:.   :||:.|||
Zfish    39 NRSRAKEKQGK---RNGERKTPEGSASPVQGQHGATNPELENLSPLDRAQSAKN---KGNKYFKA 97

  Fly   243 KEYENAIEEYNCSIIYDPE----NAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAHLR 303
            .:|::||:.|..:|...|:    :....|.|||.|:.:..|:...|.||...::::|..:||..|
Zfish    98 GKYDHAIKCYTEAIGLCPKEKKGDLSTFYQNRAAAYEQQMKWTEVIQDCSQAVELNPRYVKALFR 162

  Fly   304 MAEAHNAEGKHLESLNVYKKLLD----------FEPDNAIAKKAVEKLTSMLGE----------- 347
            .|:|       ||.|:..|:.|:          |:  |..:....:|:...||:
Zfish   163 RAKA-------LEKLDNKKECLEDVTAVCILEVFQ--NQQSMLLADKVLKQLGKEKAKEKYKNRE 218

  Fly   348 -VAP---------SSATRLIIEE-IDPPQLKTSEPKKEAEKSEPTVVKKPEPVVSAKKPPPIKDY 401
             :.|         ||.|..||.: :...:.|..:..||.|.||   ||.....:.||:....::|
Zfish   219 PLMPSPQFIKSYFSSFTDDIISQPLQKGEKKDEDKDKEGEASE---VKGSSGYLKAKQYMEEENY 280

  Fly   402 D--LAELVKPNRMVKSNLVSAAEAL----------GN-------------------KMQAS---- 431
            |  ::|..|.   ::|....:||||          ||                   |::|:
Zfish   281 DKIISECTKE---IESGGRYSAEALLLRATFYLLIGNATAAQPDLDRVINMNDASVKLRANALIK 342

  Fly   432 KGGAPKKPQSPPMTPKETLLRLPQDNLN-------NSNKLLIQEI 469
            :|....:.|.|.::.::..:....|:.|       ...|:|:.::
Zfish   343 RGSMYMQQQQPQLSTQDFNMAAEIDHRNADVYHHRGQLKILLDQV 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	21/69 (30%)
		TPR repeat	229..257	CDD:276809	10/27 (37%)
		TPR repeat	262..293	CDD:276809	9/30 (30%)
		TPR_11	266..329	CDD:290150	21/72 (29%)
		TPR	266..297	CDD:197478	10/30 (33%)
		TPR repeat	298..326	CDD:276809	9/27 (33%)
tomm70a	NP_956296.1	TPR_11	83..154	CDD:290150	22/73 (30%)
		TPR_1	84..116	CDD:278916	12/34 (35%)
		TPR repeat	84..112	CDD:276809	11/30 (37%)
		TPR repeat	122..152	CDD:276809	9/29 (31%)
		TPR	277..560	CDD:223533	20/114 (18%)
		TPR repeat	299..327	CDD:276809	6/27 (22%)
		TPR repeat	336..366	CDD:276809	4/29 (14%)
		TPR repeat	371..399	CDD:276809	2/17 (12%)
		TPR repeat	446..474	CDD:276809
		TPR repeat	479..510	CDD:276809
		TPR repeat	515..542	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1535
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940