DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Spag1 and ifit12

DIOPT Version :9

Sequence 1:NP_651514.1 Gene:Spag1 / 43239 FlyBaseID:FBgn0039463 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_001177394.1 Gene:ifit12 / 567504 ZFINID:ZDB-GENE-120406-2 Length:474 Species:Danio rerio


Alignment Length:410 Identity:84/410 - (20%)
Similarity:141/410 - (34%) Gaps:140/410 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 IHYLDFA----HVEKCTN---------------AREMEKIVQILRSGEEG--------HYPDLQR 54
            :.|.:||    |:|..|.               |.|...:.::|  ||:|        .|.|  :
Zfish    99 VTYGNFAWINYHMENYTECESYLVKLQKIHERFATESSAVPEVL--GEKGWTYLKFSRKYYD--K 159

  Fly    55 CAEEKLKALKPDS-----------KLFRYE--------------EQIKQSTDL--DKTELKPILD 92
            ..|...||::.|.           .|:|.|              :|::|:.||  |...|:.||.
Zfish   160 AVEVFQKAVELDPTNSEWNAGYAIALYRTENFNPPPCTVETPAIKQLRQAIDLNPDDDVLRVILG 224

  Fly    93 WTDAIKTKDNALNEL-----KKVKQNLNLPSV--------RKLSKIDLEKESKTEKPKPAPKATS 144
             ...:......:||.     |.:.|:...|.|        |....:|...|...:..:.:||:..
Zfish   225 -IKLLNCSKGLMNESEQLVEKALNQSPEHPHVIRYVGMFLRDQGSVDRSIEILKKALQRSPKSGF 288

  Fly   145 PSNT-----KNKEARIKSTDYRKWDKYDPDEEILRMDLNEERDQ-----EQREKIISNHSKSVTT 199
            ..:.     |.|:..:.....||            ::::|.|||     |:...:|.:...:|..
Zfish   289 ICHQLAMCYKTKKINLCKEKRRK------------VEVDEARDQSIYYLEEATSLIPSFISAVCQ 341

  Fly   200 DKLQ--SERDSLYERLQAQLKNLSQLEKEQFAERHRLRGNESFKA--------KEYEN-----AI 249
            ..||  ..||.|  :.:.|.....:|.||:         ||..::        ::|.|     ||
Zfish   342 LGLQYGDRRDLL--KAEEQFDKAFKLVKEK---------NEHLQSVHLSYAQFQQYSNRREDLAI 395

  Fly   250 EEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQAC---LQIDPMNIKAHLRMAEAHNAE 311
            |.|...:..:|..   ...||:...|           |...   |:::|.:.||:..:...:|.:
Zfish   396 EHYEKCLTMNPHT---PDGNRSAQKL-----------CNIAKKNLKLNPNDWKANEILGLVYNLK 446

  Fly   312 GKHLESLNVYKKLLDFEPDN 331
            |:..|.   |....|.|.|:
Zfish   447 GEMFER---YGNTPDNEDDS 463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spag1NP_651514.1 TPR_11 229..295 CDD:290150 14/81 (17%)
TPR repeat 229..257 CDD:276809 8/40 (20%)
TPR repeat 262..293 CDD:276809 5/33 (15%)
TPR_11 266..329 CDD:290150 13/65 (20%)
TPR 266..297 CDD:197478 6/33 (18%)
TPR repeat 298..326 CDD:276809 6/27 (22%)
ifit12NP_001177394.1 TPR repeat 55..83 CDD:276809
TPR repeat 88..127 CDD:276809 6/27 (22%)
TPR_12 97..172 CDD:290160 17/76 (22%)
TPR_2 139..174 CDD:285020 10/38 (26%)
TPR repeat 139..169 CDD:276809 9/33 (27%)
TPR repeat 174..212 CDD:276809 5/37 (14%)
TPR repeat 217..246 CDD:276809 6/29 (21%)
TPR repeat 286..331 CDD:276809 9/56 (16%)
TPR repeat 336..364 CDD:276809 7/29 (24%)
TPR repeat 374..402 CDD:276809 6/27 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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