Protein Alignment Spag1 and SGTB

DIOPT Version :10

• Sequence 1: NP_651514.1
• Gene: Spag1 / 43239
• FlyBaseID: FBgn0039463
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_061945.1
• Gene: SGTB / 54557
• HGNCID: 23567
• Length: 304
• Species: Homo sapiens
• Alignment Length: 197
• Identity: 62/197 - (31%)
• Similarity: 89/197 - (45%)
• Gaps: 22/197 - (11%)

  Fly   181 RDQEQREKIISNHSKSV--------TTDKLQSE------RDSLYERLQAQL-KN----LSQLEKE 226
            |:|.|.:...|:..:|:        |..|:..|      ...|.|...:.. ||    ||....|
Human    16 REQSQMDTYTSDEQESLEVAIQCLETVFKISPEDTHLAVSQPLTEMFTSSFCKNDVLPLSNSVPE 80

  Fly   227 QFAERHRLR--GNESFKAKEYENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQA 289
            ...:..:|:  ||...|.:.|..|::.|..:|..||.|||: |.|||.|..||..|..||.||:.
Human    81 DVGKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVY-YCNRAAAQSKLGHYTDAIKDCEK 144

  Fly   290 CLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKLLDFEPDNAIAKKAVEKLTSMLGEVAPSSAT 354
            .:.||....||:.||..|..|..|..|::..|:|.||.:|:|...|..::.....|.||:..:.|
Human   145 AIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKLREVSSPTGT 209

  Fly   355 RL 356
            .|
Human   210 GL 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	NlpI	<229..373	CDD:443815	47/130 (36%)
		TPR repeat	229..257	CDD:276809	7/29 (24%)
		TPR repeat	262..293	CDD:276809	15/30 (50%)
		TPR repeat	298..326	CDD:276809	10/27 (37%)
SGTB	NP_061945.1	SGTA_dimer	5..64	CDD:465168	10/47 (21%)
		TPR 1	15..49		7/32 (22%)
		TPR 2	85..118		10/32 (31%)
		TPR repeat	85..113	CDD:276809	7/27 (26%)
		TPR	92..>200	CDD:440225	41/108 (38%)
		TPR repeat	118..148	CDD:276809	15/30 (50%)
		TPR 3	119..152		16/33 (48%)
		TPR 4	153..186		13/32 (41%)
		TPR repeat	153..181	CDD:276809	10/27 (37%)