DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spag1 and IFIT1B

DIOPT Version :9

Sequence 1:NP_651514.1 Gene:Spag1 / 43239 FlyBaseID:FBgn0039463 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_001010987.1 Gene:IFIT1B / 439996 HGNCID:23442 Length:474 Species:Homo sapiens


Alignment Length:312 Identity:59/312 - (18%)
Similarity:121/312 - (38%) Gaps:71/312 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 EKKKSLLER--------------YNIPIHYLDFAHV----EKCTNAREMEKIVQI---------- 40
            |:.|:..|:              |.|.::.||..:.    .|..:...:::.|::          
Human   158 ERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVL 222

  Fly    41 --LRSGEEGHYPDLQRCAEEKLKALKPDSKLFRYEEQI---KQSTDLDKTELKPILDWTDAIKTK 100
              |:..:||...:.::..||.|.::...:.:|:|..:.   |.|.|.....||..|:.|......
Human   223 LALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFL 287

  Fly   101 DNALN-----ELKKVKQNLN-------LPSVRKLSKIDLEKESKTEKPKPAPKATSPSNTKNKEA 153
            .:.:.     ::.::|:..|       ..:|.:|.::.:.|..||...|   :....:.....|.
Human   288 HHQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLK---RTFEMAYVDLAET 349

  Fly   154 RIKSTDYRKWDKYDPDEEILRMDLNEE-----------RDQE----QREKIISNHSKSVTTDKLQ 203
            ..:...:||.:::  .::.|||.:.|:           |.||    .::|.|:::.|.:..:|:.
Human   350 YAEIGHHRKAEEH--FQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMS 412

  Fly   204 SERDSLYERLQAQLK-----NLSQLEKEQFAER-HRLRGNESFKAKEYENAI 249
            ..|:.|...|:...|     |:..:|....... |:|:|..|.....||.|:
Human   413 HSREKLLNALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERAL 464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spag1NP_651514.1 TPR_11 229..295 CDD:290150 7/22 (32%)
TPR repeat 229..257 CDD:276809 7/22 (32%)
TPR repeat 262..293 CDD:276809
TPR_11 266..329 CDD:290150
TPR 266..297 CDD:197478
TPR repeat 298..326 CDD:276809
IFIT1BNP_001010987.1 TPR_11 36..>298 CDD:330823 24/139 (17%)
TPR 1 52..85
TPR repeat 54..80 CDD:276809
TPR 2 95..128
TPR repeat 97..123 CDD:276809
TPR repeat 128..170 CDD:276809 3/11 (27%)
TPR 3 139..174 3/15 (20%)
TPR 4 182..216 5/33 (15%)
TPR repeat 216..246 CDD:276809 6/29 (21%)
TPR 5 251..284 9/32 (28%)
TPR repeat 251..279 CDD:276809 7/27 (26%)
TPR repeat 284..335 CDD:276809 7/50 (14%)
TPR_11 <323..469 CDD:330823 31/147 (21%)
TPR 6 340..373 6/34 (18%)
TPR repeat 340..368 CDD:276809 3/29 (10%)
TPR 7 378..412 7/33 (21%)
TPR repeat 378..407 CDD:276809 6/28 (21%)
TPR 8 437..470 8/28 (29%)
TPR repeat 437..465 CDD:276809 8/28 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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