DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and spag

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_524664.1	Gene:	spag / 43958	FlyBaseID:	FBgn0015544	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	100/474 - (21%)
Similarity:	175/474 - (36%)	Gaps:	152/474 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LKPDSKLFRYEEQIKQSTDLDKTELKPILDWTDAIKTKDNALNELKKVKQNLNLPSVRKLSKIDL 127
            :....|.|..:.|::|:....:..:|.:..|...||.|:   .||:|
  Fly     1 MSAQEKAFELQRQVRQNAREYENSVKDLYSWEQDIKNKE---KELQK------------------ 44

  Fly   128 EKESKTEKPKPAPKATSPSNTKNKEARIKSTDYRKWDKYDPDEEILRMDLNEERDQEQREKIISN 192
                            ||.:..||:..::|                    :.:.|:.::|...|:
  Fly    45 ----------------SPLSAANKDLPVRS--------------------HVQTDKSRKESPSSS 73

  Fly   193 HSKSVTTDKLQSERDSLYERLQAQLKNLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYNCSII 257
            .:.|.|     .::|...:.:..|.|..:.::.         |||...|..|||.||..|:.:|.
  Fly    74 AASSPT-----EKQDLPVDPVAQQYKKANDIKD---------RGNTYVKQGEYEKAIVAYSTAIA 124

  Fly   258 YDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYK 322
            ..|.:.:: :.|||:.:||.:.:...:.||:|.:.:|.:.:||:.|..:|:.:.|.::|:|....
  Fly   125 VYPHDPIY-HINRALCYLKQESFDQCVEDCEAAIALDKLCVKAYYRRMQANESLGNNMEALKDCT 188

  Fly   323 KLLDFEPDNAIAKKAVEKLTSMLGEVAPSSATRL------IIE--EIDPPQLKTSEPKKEAEKSE 379
            .:|..||.|..||:::.::...|.::|..|....      :||  .|:.|..|.|   |:|.:|.
  Fly   189 TVLAIEPKNIEAKRSLARINDRLRKIATKSGPNFTPDRPGMIEILPIEKPAYKRS---KKAMRSV 250

  Fly   380 PTV-----------------------------------VKKPEPVVSAKKPPPIKDYD------- 402
            |.|                                   |||..|     ||.|:.|..
  Fly   251 PVVDVVSPRATIDDSNQLRISDEDIDKIFNSNCGIIEEVKKTNP-----KPTPMPDTSGPPKAET 310

  Fly   403 LAELVKPNRMVKSNLVSAAEALGNKMQA---------------SKGGAPKKP-------QSPPMT 445
            :|:..|..:..|...|..|.|:....:.               :|..||||.       |:....
  Fly   311 IAKTSKEVKPTKQTAVKVAPAVETPKETETRKDTKIVPESDNEAKPSAPKKTAVEVPKVQTQVSP 375

  Fly   446 PKETLLRLPQDNLNNSNKL 464
            ||.|:.|.|:.|...:.|:
  Fly   376 PKTTIERSPEVNTVQTEKI 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	20/65 (31%)
		TPR repeat	229..257	CDD:276809	10/27 (37%)
		TPR repeat	262..293	CDD:276809	8/30 (27%)
		TPR_11	266..329	CDD:290150	17/62 (27%)
		TPR	266..297	CDD:197478	9/30 (30%)
		TPR repeat	298..326	CDD:276809	7/27 (26%)
spag	NP_524664.1	TPR_11	95..161	CDD:290150	20/75 (27%)
		TPR repeat	96..124	CDD:276809	10/36 (28%)
		TPR_1	102..129	CDD:278916	12/26 (46%)
		TPR repeat	129..159	CDD:276809	8/30 (27%)
		TPR	130..160	CDD:197478	8/30 (27%)
		TPR_16	136..197	CDD:290168	18/60 (30%)
		TPR repeat	164..192	CDD:276809	7/27 (26%)
		RPAP3_C	415..503	CDD:290588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462430
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840