DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and odad4

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_956610.1	Gene:	odad4 / 393286	ZFINID:	ZDB-GENE-040426-995	Length:	486	Species:	Danio rerio

Alignment Length:	279	Identity:	55/279 - (19%)
Similarity:	108/279 - (38%)	Gaps:	53/279 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 GNESFKAKEYENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKA 300
            |::.|:..||..|:|.:..::...|:|. :...:|:..::||....:|:.|.::.|:.:....|.
Zfish    21 GDQLFQRGEYVKAVESFTTALTLQPDNK-NCLVSRSRCYVKLGDAENALKDAESSLKDNKNYFKG 84

  Fly   301 HLRMAEAHNAEGKHLESLNVYKKLLDFEPD----NAIAKKAVEKLTSMLGEVAPSSATRLIIE-- 359
            ..:.|||....|....:|..|.:.....|:    ....:||.|.:.:.:|  :||| .:|:.:
Zfish    85 LYQKAEALYTMGDFEFALVYYHRGHKLRPELQEFRLGIQKAQEAIDNSVG--SPSS-VKLVNKGD 146

  Fly   360 ------EIDPPQLKTSEPK------KEAEKSEPTVVKKPEPVVSAKK--PPPIKDYDLAEL-VKP 409
                  .:.|..|..|..|      |:.:|.|.|..:....:.|.::  ...::|.||.:. ::.
Zfish   147 LSFFHNGVHPQNLNPSNKKESKKHSKKTDKGEKTAKQLLGELYSDREYLKKLLQDEDLVKCKIRS 211

  Fly   410 NRMVKSNLVSAAEALGNKMQASKGGAP----------------KKPQSPPMTPKETLLR------ 452
            ...|:..:|.:...|..:|...:...|                |....||..|...:|.
Zfish   212 GERVQDLIVGSISYLDTRMAFWQQQKPIYARQRDRKLMQQQWSKVLHKPPSDPTRYVLSSLEEID 276

  Fly   453 ------LPQDNLNNSNKLL 465
                  ..:..||.:.:|:
Zfish   277 TALSAGYTESGLNKARELM 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	14/58 (24%)
		TPR repeat	229..257	CDD:276809	6/20 (30%)
		TPR repeat	262..293	CDD:276809	7/30 (23%)
		TPR_11	266..329	CDD:290150	13/62 (21%)
		TPR	266..297	CDD:197478	6/30 (20%)
		TPR repeat	298..326	CDD:276809	7/27 (26%)
odad4	NP_956610.1	TPR 1. /evidence=ECO:0000255	14..47		7/25 (28%)
		TPR_11	16..79	CDD:290150	14/58 (24%)
		TPR repeat	16..42	CDD:276809	6/20 (30%)
		TPR repeat	47..77	CDD:276809	7/30 (23%)
		TPR 2. /evidence=ECO:0000255	49..81		6/31 (19%)
		TPR_11	50..113	CDD:290150	13/62 (21%)
		TPR 3. /evidence=ECO:0000255	82..115		8/32 (25%)
		TPR repeat	82..110	CDD:276809	7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..180		7/26 (27%)
		TPR_12	313..379	CDD:290160
		TPR 4. /evidence=ECO:0000255	314..347
		TPR repeat	316..342	CDD:276809
		TPR repeat	347..383	CDD:276809
		TPR 5. /evidence=ECO:0000255	354..387
		TPR_12	355..423	CDD:290160
		TPR 6. /evidence=ECO:0000255	391..424
		TPR 7. /evidence=ECO:0000255	431..464
		TPR repeat	431..459	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900