Protein Alignment Spag1 and Tmtc1

DIOPT Version :10

• Sequence 1: NP_651514.1
• Gene: Spag1 / 43239
• FlyBaseID: FBgn0039463
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_945318.2
• Gene: Tmtc1 / 387314
• MGIID: 3039590
• Length: 942
• Species: Mus musculus
• Alignment Length: 381
• Identity: 77/381 - (20%)
• Similarity: 141/381 - (37%)
• Gaps: 105/381 - (27%)

  Fly    32 REMEKIVQILRSGEEGHYPDLQRCAEEKLKALK------PD--------SKLFRYEEQIKQSTDL 82
            |.:..:..:|:|.|:         .||.:..||      ||        :.|...:|:.|::.|:
Mouse   609 RALFNLGNLLKSQEK---------TEEAIMLLKESIKYGPDFADAYSSLASLLAEQERFKEAEDI 664

  Fly    83 DKTELKPILDWTD-----AIKTKDNALNE--LKKVKQNLNL-PS----VRKLSKI--DLEKESKT 133
            .:..:|...|.:|     |:...|:...|  :...:|.:.| ||    |..|.::  .|.:.||.
Mouse   665 YQAGIKNCPDSSDLHNNYAVFLVDSGFPEKAVAHYQQAIQLSPSHHVAVVNLGRLYRSLGENSKA 729

  Fly   134 E-------KPKPAPKATSP-----SNT-KNKEARIKSTDYRKWDKYDPDEEILRMDLNE---ERD 182
            |       |.....:..||     .|| ::|||   ...||:.....|.:..||:.|.:   ...
Mouse   730 EEWYRRALKVARTAEVLSPLGALYYNTGRHKEA---LEVYREAVSLQPSQRELRLALAQVLAVMG 791

  Fly   183 QEQREKIISNHSKSVTTDKLQSER--DSLYERLQAQLKNLSQLEK---------EQFAERHRLRG 236
            |.:..:.|::|..|.....|:..|  .:::.:.:...|.|..:||         :..:|....:|
Mouse   792 QTKEAEKITSHIVSEEPRCLECYRLLSAIHSKQEHHGKALEAIEKALQLKPKDPKVISELFFTKG 856

  Fly   237 NESFKAKEYENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAH 301
            |:..:....:.|.|.|..::..||:.|                                   :|.
Mouse   857 NQLREQNLLDKAFESYEAAVTLDPDQA-----------------------------------QAW 886

  Fly   302 LRMAEAHNAEGKHLESLNVYKKLLDFEPDNAIAKKAVEKLTSM---LGEVAPSSAT 354
            :.|....:.:|.::.:...|::.|...||:.:.|:.:.||..:   |.||.....|
Mouse   887 MNMGGIRHIQGSYVSARAYYERALKLVPDSKLLKENLAKLDRLERRLQEVRERDQT 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	NlpI	<229..373	CDD:443815	23/129 (18%)
		TPR repeat	229..257	CDD:276809	6/27 (22%)
		TPR repeat	262..293	CDD:276809	1/30 (3%)
		TPR repeat	298..326	CDD:276809	4/27 (15%)
Tmtc1	NP_945318.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..285
		TMTC_DUF1736	351..425	CDD:462468
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	543..576
		TPR repeat	543..571	CDD:276809
		LapB	547..798	CDD:442196	45/200 (23%)
		TPR repeat	576..603	CDD:276809
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	577..607
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	608..641		9/40 (23%)
		TPR repeat	608..636	CDD:276809	8/35 (23%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	642..675		5/32 (16%)
		TPR repeat	642..670	CDD:276809	4/27 (15%)
		TPR repeat	675..705	CDD:276809	5/29 (17%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	676..709		7/32 (22%)
		LapB	683..938	CDD:442196	59/292 (20%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	710..742		7/31 (23%)
		TPR repeat	710..738	CDD:276809	6/27 (22%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	743..776		10/35 (29%)
		TPR repeat	743..771	CDD:276809	9/30 (30%)
		TPR repeat	776..806	CDD:276809	6/29 (21%)
		TPR 8. /evidence=ECO:0000255	777..810		7/32 (22%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	811..844		6/32 (19%)
		TPR repeat	812..839	CDD:276809	5/26 (19%)
		TPR repeat	844..878	CDD:276809	6/33 (18%)
		TPR 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	849..882		8/32 (25%)
		TPR 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	883..916		7/67 (10%)
		TPR repeat	883..911	CDD:276809	5/62 (8%)