DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spag1 and Tmtc1

DIOPT Version :9

Sequence 1:NP_651514.1 Gene:Spag1 / 43239 FlyBaseID:FBgn0039463 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_945318.2 Gene:Tmtc1 / 387314 MGIID:3039590 Length:942 Species:Mus musculus


Alignment Length:381 Identity:77/381 - (20%)
Similarity:141/381 - (37%) Gaps:105/381 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 REMEKIVQILRSGEEGHYPDLQRCAEEKLKALK------PD--------SKLFRYEEQIKQSTDL 82
            |.:..:..:|:|.|:         .||.:..||      ||        :.|...:|:.|::.|:
Mouse   609 RALFNLGNLLKSQEK---------TEEAIMLLKESIKYGPDFADAYSSLASLLAEQERFKEAEDI 664

  Fly    83 DKTELKPILDWTD-----AIKTKDNALNE--LKKVKQNLNL-PS----VRKLSKI--DLEKESKT 133
            .:..:|...|.:|     |:...|:...|  :...:|.:.| ||    |..|.::  .|.:.||.
Mouse   665 YQAGIKNCPDSSDLHNNYAVFLVDSGFPEKAVAHYQQAIQLSPSHHVAVVNLGRLYRSLGENSKA 729

  Fly   134 E-------KPKPAPKATSP-----SNT-KNKEARIKSTDYRKWDKYDPDEEILRMDLNE---ERD 182
            |       |.....:..||     .|| ::|||   ...||:.....|.:..||:.|.:   ...
Mouse   730 EEWYRRALKVARTAEVLSPLGALYYNTGRHKEA---LEVYREAVSLQPSQRELRLALAQVLAVMG 791

  Fly   183 QEQREKIISNHSKSVTTDKLQSER--DSLYERLQAQLKNLSQLEK---------EQFAERHRLRG 236
            |.:..:.|::|..|.....|:..|  .:::.:.:...|.|..:||         :..:|....:|
Mouse   792 QTKEAEKITSHIVSEEPRCLECYRLLSAIHSKQEHHGKALEAIEKALQLKPKDPKVISELFFTKG 856

  Fly   237 NESFKAKEYENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAH 301
            |:..:....:.|.|.|..::..||:.|                                   :|.
Mouse   857 NQLREQNLLDKAFESYEAAVTLDPDQA-----------------------------------QAW 886

  Fly   302 LRMAEAHNAEGKHLESLNVYKKLLDFEPDNAIAKKAVEKLTSM---LGEVAPSSAT 354
            :.|....:.:|.::.:...|::.|...||:.:.|:.:.||..:   |.||.....|
Mouse   887 MNMGGIRHIQGSYVSARAYYERALKLVPDSKLLKENLAKLDRLERRLQEVRERDQT 942

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spag1NP_651514.1 TPR_11 229..295 CDD:290150 9/65 (14%)
TPR repeat 229..257 CDD:276809 6/27 (22%)
TPR repeat 262..293 CDD:276809 1/30 (3%)
TPR_11 266..329 CDD:290150 5/62 (8%)
TPR 266..297 CDD:197478 0/30 (0%)
TPR repeat 298..326 CDD:276809 4/27 (15%)
Tmtc1NP_945318.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 245..285
DUF1736 351..425 CDD:285594
TPR_11 542..605 CDD:290150
TPR 1 543..576
TPR_2 543..576 CDD:285020
TPR repeat 543..571 CDD:276809
TPR repeat 576..603 CDD:276809
TPR 2 577..607
TPR 577..607 CDD:197478
TPR_17 596..628 CDD:290167 6/27 (22%)
TPR 3 608..641 9/40 (23%)
TPR repeat 608..636 CDD:276809 8/35 (23%)
TPR 621..940 CDD:223533 73/365 (20%)
TPR 4 642..675 5/32 (16%)
TPR repeat 642..670 CDD:276809 4/27 (15%)
TPR repeat 675..705 CDD:276809 5/29 (17%)
TPR 5 676..709 7/32 (22%)
TPR 6 710..742 7/31 (23%)
TPR repeat 710..738 CDD:276809 6/27 (22%)
TPR_7 715..744 CDD:289919 6/28 (21%)
TPR 7 743..776 10/35 (29%)
TPR repeat 743..771 CDD:276809 9/30 (30%)
TPR_14 749..786 CDD:290164 11/39 (28%)
TPR repeat 776..806 CDD:276809 6/29 (21%)
TPR 8 811..844 6/32 (19%)
TPR repeat 812..839 CDD:276809 5/26 (19%)
TPR repeat 844..878 CDD:276809 6/33 (18%)
TPR 9 849..882 8/32 (25%)
TPR 10 883..916 7/67 (10%)
TPR_1 883..915 CDD:278916 6/66 (9%)
TPR repeat 883..911 CDD:276809 5/62 (8%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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