Protein Alignment Spag1 and IFIT1

DIOPT Version :10

• Sequence 1: NP_651514.1
• Gene: Spag1 / 43239
• FlyBaseID: FBgn0039463
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_001539.3
• Gene: IFIT1 / 3434
• HGNCID: 5407
• Length: 478
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 61/309 - (19%)
• Similarity: 114/309 - (36%)
• Gaps: 73/309 - (23%)

  Fly    36 KIVQILRSGEEGHYPDLQRCAEEKLKALKPDSKLFRYEEQI-KQSTDLDKTELKPILDWTDAIKT 99
            |::..|:..:||...:.::..||.|..:...:.:|||..:. ::...:||
Human   220 KVLLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYAAKFYRRKGSVDK--------------- 269

  Fly   100 KDNALNELKKVKQNLNLPSVRKLSKIDLEKESKTEKPKPAPKATSPSNTKNK-EARIKST--DYR 161
               ||..|||..|. ...||....:|.|..:::..:.|.|.|.......:.| :..|:|.  .:.
Human   270 ---ALELLKKALQE-TPTSVLLHHQIGLCYKAQMIQIKEATKGQPRGQNREKLDKMIRSAIFHFE 330

  Fly   162 KWDKYDPDEEILRMDL--------NEERDQEQREKIISNHSKSVTTDKLQSERDSLYERLQAQLK 218
            ...:..|..|:..:||        |..:.:|..:|::.  .|.|..:.:| :....|.|.|
Human   331 SAVEKKPTFEVAHLDLARMYIEAGNHRKAEENFQKLLC--MKPVVEETMQ-DIHFHYGRFQ---- 388

  Fly   219 NLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSA 283
                                .|:.|...|||..|..:|..:..:.....:..::..|.|:|
Human   389 --------------------EFQKKSDVNAIIHYLKAIKIEQASLTRDKSINSLKKLVLRK---- 429

  Fly   284 ISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKLL----DFE 328
                   |:...:::::...:...:..||...|:|..|::.|    |||
Human   430 -------LRRKALDLESLSLLGFVYKLEGNMNEALEYYERALRLAADFE 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	NlpI	<229..373	CDD:443815	20/104 (19%)
		TPR repeat	229..257	CDD:276809	6/27 (22%)
		TPR repeat	262..293	CDD:276809	4/30 (13%)
		TPR repeat	298..326	CDD:276809	6/31 (19%)
IFIT1	NP_001539.3	TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	52..85
		TPR repeat	54..80	CDD:276809
		TPR	55..>245	CDD:440225	6/24 (25%)
		TPR 2. /evidence=ECO:0000255	95..128
		TPR repeat	97..123	CDD:276809
		TPR repeat	128..170	CDD:276809
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	141..174
		LapB	156..465	CDD:442196	57/301 (19%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	183..216
		TPR repeat	216..246	CDD:276809	7/25 (28%)
		TPR 5. /evidence=ECO:0000255	218..249		7/28 (25%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	251..284		11/51 (22%)
		TPR repeat	252..279	CDD:276809	10/44 (23%)
		TPR repeat	284..335	CDD:276809	10/50 (20%)
		TPR 7. /evidence=ECO:0000255	305..339		6/33 (18%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	340..373		7/34 (21%)
		TPR repeat	340..367	CDD:276809	6/26 (23%)
		TPR 9. /evidence=ECO:0000255	378..412		11/58 (19%)
		TPR repeat	378..407	CDD:276809	10/53 (19%)
		TPR 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	437..470		6/32 (19%)
		TPR repeat	437..465	CDD:276809	5/27 (19%)