DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and IFIT2

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001538.4	Gene:	IFIT2 / 3433	HGNCID:	5409	Length:	472	Species:	Homo sapiens

Alignment Length:	337	Identity:	69/337 - (20%)
Similarity:	124/337 - (36%)	Gaps:	125/337 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 EEKLKALK---------PDSKLFRYEEQIKQSTDLDKTELKPILDWTDAIKTKDNALNELKKVK- 111
            |..|:.||         .::.|..:|:::...|:....|.|         .|..|.|..||.:|
Human    10 ESSLRQLKCHFTWNLMEGENSLDDFEDKVFYRTEFQNREFK---------ATMCNLLAYLKHLKG 65

  Fly   112 QNLNLPSVRKLSKIDLEKESKTEKPKPAPKATSPSNTKNKEARIKSTDYRKWDKYDPDEEILRMD 176
            ||                |:..|..:.|                              ||:::
Human    66 QN----------------EAALECLRKA------------------------------EELIQ-- 82

  Fly   177 LNEERDQEQREKIIS--NHS-----------KSVTTDKLQ--SERDSLYERLQAQLKNLSQLEKE 226
             .|..||.:...:::  |::           ..:..||::  .|:.|...|:::     .:|:.|
Human    83 -QEHADQAEIRSLVTWGNYAWVYYHMGRLSDVQIYVDKVKHVCEKFSSPYRIES-----PELDCE 141

  Fly   227 QFAERHRLRGNESFKAKE-YENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKY---FSAISDC 287
            :...|.:..||::.:||. :|.|:|:       .|:|.... :..|:|..:|..:   .:||...
Human   142 EGWTRLKCGGNQNERAKVCFEKALEK-------KPKNPEFT-SGLAIASYRLDNWPPSQNAIDPL 198

  Fly   288 QACLQIDPMN--------IKAH-LRMAEAHNAEGKHL--ESL-------NVYKKLLDF-----EP 329
            :..::::|.|        :|.| :|.......||:.|  |:|       :|.:....|     ||
Human   199 RQAIRLNPDNQYLKVLLALKLHKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEP 263

  Fly   330 DNAI--AKKAVE 339
            |.||  .|||:|
Human   264 DKAIELLKKALE 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	15/69 (22%)
		TPR repeat	229..257	CDD:276809	8/28 (29%)
		TPR repeat	262..293	CDD:276809	6/33 (18%)
		TPR_11	266..329	CDD:290150	17/88 (19%)
		TPR	266..297	CDD:197478	6/33 (18%)
		TPR repeat	298..326	CDD:276809	9/37 (24%)
IFIT2	NP_001538.4	TPR_12	51..112	CDD:290160	17/109 (16%)
		TPR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	51..89		15/86 (17%)
		TPR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	90..135		6/44 (14%)
		TPR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	136..171		11/41 (27%)
		TPR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	172..208		6/36 (17%)
		TPR repeat	208..236	CDD:276809	6/27 (22%)
		TPR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	247..280		11/29 (38%)
		TPR repeat	248..275	CDD:276809	10/26 (38%)
		TPR repeat	280..329	CDD:276809
		TPR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	281..335
		TPR repeat	334..359	CDD:276809
		TPR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	336..366
		TPR 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	367..405
		TPR 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	406..448
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900