Protein Alignment Spag1 and Spag1

DIOPT Version :10

• Sequence 1: NP_651514.1
• Gene: Spag1 / 43239
• FlyBaseID: FBgn0039463
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_001012116.1
• Gene: Spag1 / 315033
• RGDID: 1310702
• Length: 893
• Species: Rattus norvegicus
• Alignment Length: 367
• Identity: 113/367 - (30%)
• Similarity: 195/367 - (53%)
• Gaps: 54/367 - (14%)

  Fly    13 YNIPIHYLDFAHVEKCTNAREMEKIVQILRSGEEGHYPDLQRCAEEKLKALKPDSKLFRYEEQIK 77
            :.|||.:|||.::|.|::.:::|||:.:|||||||:||:|....|::|..|.|.|:..|.::...
  Rat    20 FKIPIEHLDFKYIENCSDVKQLEKILCVLRSGEEGYYPELTEFCEKRLTGLAPRSRALRKDKPAA 84

  Fly    78 QSTDLDKTELKPI----LDWTDAIKTKDNALNELKKVKQNLNLPSVRKLSKIDLEKESKTEKPKP 138
            .::.....|.:.|    ..|...||.::|                .|...  |.||....|.|.|
  Rat    85 TASSFSAEEWEKIDSDLKSWVSEIKREEN----------------TRHFH--DPEKHPGVEDPLP 131

  Fly   139 -------APKATSPSNTKNKEARIK-STDYRKWDKYDPDEEILRMDLNEERDQEQREKIISNHSK 195
                   .|:....:::|:|.|:.: ..||.:|||:|.::|..::      |::.:||.:.|:..
  Rat   132 PVRGSNSCPRGGKETSSKSKTAKKRIPRDYAEWDKFDVEKECSKI------DEDYKEKTVINNKA 190

  Fly   196 SVTTDKLQSERDSLYERLQAQLKNLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYNCSIIYDP 260
            .::  |::::.|:         ..|::.||...|.|.:.:|||:|.:.:||.|:..|..|:...|
  Rat   191 HLS--KIETKIDT---------AGLTEKEKNFLANREKGKGNEAFYSGDYEEAVMYYTRSLSALP 244

  Fly   261 ENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKLL 325
              ...||||||.|.:||:::.||:.||:..|:::|.||||.||.|..:..:.|.||:::..:|:|
  Rat   245 --TATAYNNRAQAEIKLQRWSSALEDCEKALELEPGNIKALLRRATTYKHQNKFLEAVDDLRKVL 307

  Fly   326 DFEPDNAIAKKAVEKLTSMLGEVAPSS-----ATRLIIEEID 362
            ..||||.:|||.:.::...|....|:|     ..|::|||::
  Rat   308 QAEPDNDLAKKTLSEVERELKNSEPASELQTKGKRMVIEEVE 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	NlpI	<229..373	CDD:443815	53/139 (38%)
		TPR repeat	229..257	CDD:276809	11/27 (41%)
		TPR repeat	262..293	CDD:276809	14/30 (47%)
		TPR repeat	298..326	CDD:276809	10/27 (37%)
Spag1	NP_001012116.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..155		8/49 (16%)
		TPR 1	213..246		8/32 (25%)
		TPR repeat	217..241	CDD:276809	5/23 (22%)
		TPR	218..>336	CDD:440225	42/117 (36%)
		TPR repeat	246..275	CDD:276809	8/28 (29%)
		TPR 2	247..279		12/31 (39%)
		TPR 3	280..313		15/32 (47%)
		TPR repeat	280..308	CDD:276809	12/27 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	324..344		8/19 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..368		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	373..437
		TPR 4	429..463
		3a0801s09	<432..>569	CDD:273380
		TPR repeat	432..458	CDD:276809
		TPR repeat	466..500	CDD:276809
		TPR 5	471..504
		TPR repeat	505..533	CDD:276809
		TPR 6	506..538
		TPR	601..>713	CDD:440225
		TPR 7	605..638
		TPR repeat	606..633	CDD:276809
		TPR repeat	638..668	CDD:276809
		TPR 8	639..672
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..756
		RPAP3_C	770..861	CDD:464012