DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spag1 and Tmtc3

DIOPT Version :9

Sequence 1:NP_651514.1 Gene:Spag1 / 43239 FlyBaseID:FBgn0039463 Length:469 Species:Drosophila melanogaster
Sequence 2:XP_017450330.2 Gene:Tmtc3 / 314785 RGDID:1306351 Length:1022 Species:Rattus norvegicus


Alignment Length:449 Identity:86/449 - (19%)
Similarity:153/449 - (34%) Gaps:177/449 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   147 NTKNKEARIKSTDYRKWDKYDPDEEILRM-------DLNEERDQEQREKIISNHSKSVTTDKLQS 204
            |.||.|..:|.  :.:.....||:....|       :||..::.|:...:..:....:...|..:
  Rat   565 NEKNFEKALKY--FLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMLAKSLMPQIIPGKKYA 627

  Fly   205 ER------------DSLYERLQAQLKNLSQLEKE------QFAERHRLRG------NESFKAKE- 244
            .|            .:|....:::|:...||.::      .|.:.:..||      |:..|||| 
  Rat   628 ARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEA 692

  Fly   245 YENAIE--------EYNCSIIY----DPENAVHAYN--------------NRAV-----AHLKLK 278
            |..|:|        .||.:|:|    :|:.|:..:|              |.|:     ..:||:
  Rat   693 YLKALELDRNNADLWYNLAIVYIELKEPDEALKNFNRALELNSRHKLALFNSAILMQESGEVKLR 757

  Fly   279 K-------------------YFS----AISD---------CQACLQIDPMNIKAHLRMAEAHNAE 311
            .                   ||:    |:.|         .:..:::.|....|...:|..::..
  Rat   758 PEARKRLLNYINEEPQDANGYFNLGMLAMDDKKDSEAETWMKRAIKLQPDFRSALFNLALLYSQT 822

  Fly   312 GKHLESLNVYKKLLDFEPDN------------------AIAKKAVEKLTSMLGEVAPSS------ 352
            .|.|::|.:.::||.:.||:                  |.|||..||:.    |:.||:      
  Rat   823 AKELKALPILEELLRYYPDHTKGLILKGDILMNQKKDIAGAKKCFEKIL----EMDPSNVQGKHN 883

  Fly   353 -------------ATRLIIE---------------EIDPPQLKTS----EPKKEAEKSEPTVVKK 385
                         |.|.::|               .|...::.:|    :|....:|:..|..|.
  Rat   884 LCVVYFEEKDLLKAERCLVETLALAPHEEYIQRHLSIVRDKIASSGIVDQPLSPVDKTSGTEEKD 948

  Fly   386 PEP------VVSAKKPPPIKDYDLAELVKPNRMVKSNLVSAAEALGNKMQASKGGAPKK 438
            ..|      ::|..:|        |:::|.|...||.  |..::.||..|    .||.|
  Rat   949 EVPSEDVKEIISESRP--------AQIIKTNDNRKSQ--SNKQSTGNADQ----DAPHK 993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spag1NP_651514.1 TPR_11 229..295 CDD:290150 25/135 (19%)
TPR repeat 229..257 CDD:276809 12/42 (29%)
TPR repeat 262..293 CDD:276809 10/81 (12%)
TPR_11 266..329 CDD:290150 17/113 (15%)
TPR 266..297 CDD:197478 10/81 (12%)
TPR repeat 298..326 CDD:276809 6/27 (22%)
Tmtc3XP_017450330.2 DUF1736 366..438 CDD:400627
PEP_TPR_lipo <542..909 CDD:274350 65/349 (19%)
TPR repeat 553..581 CDD:276809 5/17 (29%)
TPR repeat 586..630 CDD:276809 5/43 (12%)
TPR repeat 637..664 CDD:276809 4/26 (15%)
TPR repeat 669..699 CDD:276809 10/29 (34%)
TPR repeat 704..732 CDD:276809 7/27 (26%)
TPR repeat 775..803 CDD:276809 4/27 (15%)
TPR repeat 808..838 CDD:276809 7/29 (24%)
TPR repeat 843..872 CDD:276809 6/32 (19%)
TPR repeat 878..901 CDD:276809 2/22 (9%)
ParB_N_Srx 901..>943 CDD:421688 5/41 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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