DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and Tmtc2

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001164648.2	Gene:	Tmtc2 / 299762	RGDID:	1309848	Length:	836	Species:	Rattus norvegicus

Alignment Length:	328	Identity:	63/328 - (19%)
Similarity:	116/328 - (35%)	Gaps:	100/328 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 SKSVTTDKLQSERDSLYER--LQAQLKNLSQL--EKEQFAERHRLRGNESFKAKEYENAIEEYNC 254
            |:|..::...:.|::||.|  :...|.||..|  |..:|||                 |:..|..
  Rat   505 SQSKISEAEIAYRNALYYRSNMADMLYNLGLLLQENSRFAE-----------------ALHYYKL 552

  Fly   255 SIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIK---AH--------LRMAEAH 308
            ::...|..| .||.|..:..:...|...|......|.:|...|:|   ||        ..:.:.:
  Rat   553 AVGSRPTLA-SAYLNTGIILMNQGKTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLY 616

  Fly   309 NAEGKHLESLNVYKKLLDFEPDNAIAKKAVEKLTSMLGEV------------------------- 348
            :.:|::.|:|:||::.:...|    .:.|.:.|.:|:||.
  Rat   617 HEQGRYEEALSVYREAIQKMP----RQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHI 677

  Fly   349 --------------APSSATRLIIE--EIDPPQ-----------------LKTSEPKKEAEKSEP 380
                          ..|.|.:..::  |:||.:                 .:.:|..|:|.:.:.
  Rat   678 PAHLTYGKLLALTGRKSEAEKFFLKAIELDPTKGNCYMHYGQFLLEESRLTEAAEMAKKAAELDS 742

  Fly   381 T---VVKKPEPVV--SAKKPPPIKDYDLAELVKPNRMVKSNLVSAAEALGNKMQASKGGAPKKPQ 440
            |   ||.....::  ::......|.||||..::||.......:.|...|..::|.::....:..|
  Rat   743 TEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQ 807

  Fly   441 SPP 443
            ..|
  Rat   808 LKP 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	13/65 (20%)
		TPR repeat	229..257	CDD:276809	4/27 (15%)
		TPR repeat	262..293	CDD:276809	7/30 (23%)
		TPR_11	266..329	CDD:290150	16/73 (22%)
		TPR	266..297	CDD:197478	7/30 (23%)
		TPR repeat	298..326	CDD:276809	8/38 (21%)
Tmtc2	NP_001164648.2	DUF1736	247..321	CDD:285594
		TPR_11	493..554	CDD:290150	16/65 (25%)
		TPR repeat	493..521	CDD:276809	3/15 (20%)
		TPR repeat	527..555	CDD:276809	10/44 (23%)
		TPR_12	557..634	CDD:290160	18/77 (23%)
		TPR repeat	560..590	CDD:276809	7/30 (23%)
		TPR repeat	595..634	CDD:276809	8/38 (21%)
		TPR_12	607..671	CDD:290160	11/67 (16%)
		TPR_2	609..638	CDD:285020	6/32 (19%)
		TPR repeat	642..671	CDD:276809	4/28 (14%)
		TPR repeat	679..705	CDD:276809	2/25 (8%)
		TPR repeat	710..774	CDD:276809	11/63 (17%)
		TPR_19	755..822	CDD:291240	12/56 (21%)
		TPR_1	779..812	CDD:278916	5/32 (16%)
		TPR repeat	779..807	CDD:276809	3/27 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900