DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and Lonrf3

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_006257509.1	Gene:	Lonrf3 / 298322	RGDID:	1565451	Length:	809	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	92/422 - (21%)
Similarity:	154/422 - (36%)	Gaps:	112/422 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AHVEKCTNAREMEKIVQILRSGEEGHYPDLQRCAEEKLKALKPDSKLFRYEEQIKQSTDLDKTEL 87
            ||.||.|               .||..|              |.::.....:.:..||   ..|.
  Rat    40 AHSEKVT---------------PEGSQP--------------PGAQEPEQSQPLAAST---PPEC 72

  Fly    88 KPILDWTDAIKTKDNALNELKKV------KQNLNLPSVRKLSKIDLEKESKTEKPKPAPKATSPS 146
            |.:|...||:.::.: |.|..:|      :|.|....:.:|.:...:...:.|...|||  ..||
  Rat    73 KVLLTQADALASRGH-LREALEVYRQLSERQQLVAEQLEQLVRCLADSIPQDELMAPAP--ADPS 134

  Fly   147 NTKN-------KEARIKSTDYRKWDKY----------DP-----DEEILRMDLNEERDQEQREKI 189
            .|.:       |.....:.....||.:          ||     .....::.|...|..::|..:
  Rat   135 ATSSCCAAALKKAGEAAAVAPEVWDGFKCRKCHGFLSDPVSLWCGHTFCKLCLERGRAADRRCAL 199

  Fly   190 --ISNHSKSVTTDKLQSERDS-----LYERLQAQLKNL-----------SQLEKEQFAERHRLRG 236
              :...:..|.:.:.:..|.|     |..|:...|..|           |||..|         |
  Rat   200 CGVKLSALMVASGRARGPRRSGPQAPLQLRVNVVLSGLLGKLFPGPARASQLRHE---------G 255

  Fly   237 NESFKAKEYENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAH 301
            |..::.::.|.|:.:||.::...|.:.: .|:||:..:..|:.:..|:.|.:...::.||..|||
  Rat   256 NRLYRERQVEAALLKYNEAVRLAPNDHL-LYSNRSQIYFTLESHEDALHDAEIACKLRPMGFKAH 319

  Fly   302 LRMAEAHNAEGKHLESLNVYKKLLDFEPDNAIAKKAVEKL------TSMLGEVAPSSATRLIIEE 360
            .|.|:|....||..|:|..:...:..:..|..|:...::|      .|:.||....|..  |::.
  Rat   320 FRKAQALATLGKVKEALREFLYCVSLDGKNKRARSEAQRLLFSFFSPSVPGESQEHSPD--ILKL 382

  Fly   361 IDP-PQLK----------TSE--PKKEAEKSE 379
            :.| |:||          ||.  ||...|.||
  Rat   383 LAPHPRLKEHVESMATEGTSHNLPKLSQENSE 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	13/65 (20%)
		TPR repeat	229..257	CDD:276809	6/27 (22%)
		TPR repeat	262..293	CDD:276809	6/30 (20%)
		TPR_11	266..329	CDD:290150	18/62 (29%)
		TPR	266..297	CDD:197478	7/30 (23%)
		TPR repeat	298..326	CDD:276809	10/27 (37%)
Lonrf3	XP_006257509.1	RING	163..200	CDD:302633	5/36 (14%)
		TPR_11	247..313	CDD:290150	17/75 (23%)
		TPR repeat	248..276	CDD:276809	10/36 (28%)
		TPR repeat	281..311	CDD:276809	6/30 (20%)
		TPR repeat	316..339	CDD:276809	10/22 (45%)
		RING	516..555	CDD:238093
		LON_substr_bdg	605..806	CDD:280370
		LON	616..802	CDD:271862
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810