DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spag1 and Tomm70a

DIOPT Version :9

Sequence 1:NP_651514.1 Gene:Spag1 / 43239 FlyBaseID:FBgn0039463 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_613065.2 Gene:Tomm70a / 28185 MGIID:106295 Length:611 Species:Mus musculus


Alignment Length:310 Identity:74/310 - (23%)
Similarity:130/310 - (41%) Gaps:85/310 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 LSQLEKEQFAERHRLRGNESFKAKEYENAIEEYNCSIIYDP-ENAVHA---YNNRAVAHLKLKKY 280
            :|.|::.|.|:.   :||:.|||.:||.||:.|..:|...| |..|..   |.|||.|..:|:|:
Mouse   111 MSSLDRAQAAKN---KGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKW 172

  Fly   281 FSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKLLD----------FEPDNAIAK 335
            .....||...::::|..:||..|.|:||       |.|:..|:.|:          |:.:.::. 
Mouse   173 KEVAQDCTKAVELNPKYVKALFRRAKAH-------EKLDNKKECLEDVTAVCILEGFQNEQSML- 229

  Fly   336 KAVEKLTSMLGE------------VAP---------SSATRLIIEEIDPPQLKTSEPKKEAEK-S 378
             ..:|:..:||:            :.|         ||.|..||.:   |.||..:..::.:| .
Mouse   230 -LADKVLKLLGKENAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQ---PMLKGEKSDEDKDKEG 290

  Fly   379 EPTVVKKPEPVVSAKKPPPIKDYD----------------LAE----------LVKPNRMVKSNL 417
            |...||:....:.||:....::||                :||          |:......|.:|
Mouse   291 EALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAQGKYMAEALLLRATFYLLIGSANAAKPDL 355

  Fly   418 ---VSAAEALGNKMQAS----KGGAPKKPQSPPMTPKETLLRLPQDNLNN 460
               :|..|| ..|::|:    :|....:.|.|.::.::..:....|.:|:
Mouse   356 DKVISLKEA-NVKLRANALIKRGTMCMQQQQPMLSTQDFNMAAEIDPMNS 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spag1NP_651514.1 TPR_11 229..295 CDD:290150 24/69 (35%)
TPR repeat 229..257 CDD:276809 11/27 (41%)
TPR repeat 262..293 CDD:276809 10/33 (30%)
TPR_11 266..329 CDD:290150 21/75 (28%)
TPR 266..297 CDD:197478 10/33 (30%)
TPR repeat 298..326 CDD:276809 9/27 (33%)
Tomm70aNP_613065.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 69..110
PLN03088 <117..604 CDD:330826 72/304 (24%)
TPR 1 117..150 14/35 (40%)
TPR repeat 117..145 CDD:276809 12/30 (40%)
TPR repeat 155..185 CDD:276809 9/29 (31%)
TPR 2 156..189 10/32 (31%)
TPR 3 297..330 4/32 (13%)
TPR 4 332..365 8/33 (24%)
TPR repeat 332..360 CDD:276809 5/27 (19%)
TPR repeat 365..399 CDD:276809 5/33 (15%)
TPR 5 370..403 5/32 (16%)
TPR 6 404..437 0/1 (0%)
TPR repeat 404..432 CDD:276809 0/1 (0%)
TPR 7 445..478
TPR repeat 447..473 CDD:276809
TPR 8 479..512
TPR repeat 479..507 CDD:276809
TPR repeat 512..543 CDD:276809
TPR 9 514..547
TPR 10 548..581
TPR repeat 548..575 CDD:276809
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1535
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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