DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and Spag1

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001346910.1	Gene:	Spag1 / 26942	MGIID:	1349387	Length:	913	Species:	Mus musculus

Alignment Length:	367	Identity:	111/367 - (30%)
Similarity:	188/367 - (51%)	Gaps:	54/367 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 YNIPIHYLDFAHVEKCTNAREMEKIVQILRSGEEGHYPDLQRCAEEKLKALKPDSKLFRYEEQIK 77
            :.|||.:|||.::|.|::.:.:|||:.:|||||||:||:|....|:.|..|.|.|:..|.::..:
Mouse    32 FKIPIEHLDFKYIENCSDVKHLEKILYVLRSGEEGYYPELTEFCEKCLTNLAPKSRALRKDKPAE 96

  Fly    78 QSTDLDKTELKPI----LDWTDAIKTKDNALNELKKVKQNLNLPSVRKLSKIDLEKESKTEKPKP 138
            .::.....|.:.|    ..|...||.::|..:                  ..|.|.....|.|.|
Mouse    97 TASSFSAEEWEKIDSDLKSWVSEIKREENTCH------------------FHDPENHPGVEDPLP 143

  Fly   139 -------APKATSPSNTKNKEARIK-STDYRKWDKYDPDEEILRMDLNEERDQEQREKIISNHSK 195
                   .|.:...:.:|:|.|:.: ..||.:|||:|.::|..::      |::.:||.:.|:..
Mouse   144 PVRGSTCCPHSGKETYSKSKTAKKRIPRDYAEWDKFDVEKECSKI------DEDYKEKTVINNKA 202

  Fly   196 SVTTDKLQSERDSLYERLQAQLKNLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYNCSIIYDP 260
            .::..:.:.|...|.|:           ||...|.|.:.:|||:|.:.:||.|:..|..|:...|
Mouse   203 HLSKIETKIETAGLTEK-----------EKSFLANREKGKGNEAFYSGDYEEAVMYYTRSLSALP 256

  Fly   261 ENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKLL 325
             .|: ||||||.|.:||:::.||:.||:..|::||.|:||.||.|..:..:.|..|:::..:|:|
Mouse   257 -TAI-AYNNRAQAEIKLQRWSSALEDCEKALELDPGNVKALLRRATTYKHQNKLQEAVDDLRKVL 319

  Fly   326 DFEPDNAIAKKAVEKLTSMLGEVAPSS-----ATRLIIEEID 362
            ..||||.:|||.:.::...|....|.|     ..|::|||::
Mouse   320 QVEPDNDLAKKTLSEVERDLKNSEPVSELQTKGKRMVIEEVE 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	27/65 (42%)
		TPR repeat	229..257	CDD:276809	11/27 (41%)
		TPR repeat	262..293	CDD:276809	15/30 (50%)
		TPR_11	266..329	CDD:290150	26/62 (42%)
		TPR	266..297	CDD:197478	16/30 (53%)
		TPR repeat	298..326	CDD:276809	8/27 (30%)
Spag1	NP_001346910.1	3a0801s09	214..698	CDD:273380	58/173 (34%)
		TPR repeat	229..253	CDD:276809	5/23 (22%)
		TPR repeat	258..287	CDD:276809	9/28 (32%)
		TPR repeat	292..320	CDD:276809	12/27 (44%)
		TPR repeat	445..471	CDD:276809
		TPR repeat	483..513	CDD:276809
		TPR repeat	518..546	CDD:276809
		TPR repeat	619..646	CDD:276809
		PLN03088	631..>807	CDD:215568
		TPR repeat	651..681	CDD:276809
		RPAP3_C	789..878	CDD:404718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6882
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8081
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153676at33208
OrthoFinder	1	1.000	-	-		FOG0008026
OrthoInspector	1	1.000	-	-		otm43674
orthoMCL	1	0.900	-	-		OOG6_105718
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1535
SonicParanoid	1	1.000	-	-		X6081
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750