DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and Kdm6a

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_006527657.1	Gene:	Kdm6a / 22289	MGIID:	1095419	Length:	1476	Species:	Mus musculus

Alignment Length:	440	Identity:	89/440 - (20%)
Similarity:	157/440 - (35%)	Gaps:	122/440 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 DNALNELKKVKQNLNLPSVRKLSKIDLEKESKTEKPKPAPKATSPSNTKNKEARIKSTD-YRKWD 164
            |.:....|::...|.|     :.|::.:.||..:..:.|....:|....|.|.:..... |....
Mouse   162 DPSFCRAKEIHLRLGL-----MFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQR 221

  Fly   165 KYDPDEEILRMDLNEERDQEQREKII------SNHSKSVTTDKLQSERDSLYERLQAQL------ 217
            ||...:|.....|..|....|.:..|      .:|:..:..||...|..:: :.||..|
Mouse   222 KYHSAKEAYEQLLQTENLSAQVKATILQQLGWMHHTVDLLGDKATKESYAI-QYLQKSLEADPNS 285

  Fly   218 --------KNLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYN------CSI--IYDPEN---- 262
                    :..|.:.|.|          ::|.:  |..:|::..      |||  :|..:|
Mouse   286 GQSWYFLGRCYSSIGKVQ----------DAFIS--YRQSIDKSEASADTWCSIGVLYQQQNQPMD 338

  Fly   263 AVHAY-------NNRAVAHLKLKKYFSAISDCQACLQIDPMN-IKAHLRMAEAHNAEGKHLESLN 319
            |:.||       :..|.|.:.|...:      ::|.|  |.: ||.:|....:.|.  .:...|.
Mouse   339 ALQAYICAVQLDHGHAAAWMDLGTLY------ESCNQ--PQDAIKCYLNATRSKNC--SNTSGLA 393

  Fly   320 VYKKLLDFEPDNAIAKKAVEKLTSMLGEVAPSSATRLIIEEI----DPPQLKTSEP--------- 371
            ...|.|..:..| :.:.:::..|.:|    ||      |||.    .|.:|.:.:.
Mouse   394 ARIKYLQAQLCN-LPQGSLQNKTKLL----PS------IEEAWSLPIPAELTSRQGAMNTAQQAC 447

  Fly   372 KKEAEKSEPTVVKKPEPVVSAKKP----PPIKDYDLAELVKPNRMVKSNLVSAAEALGNKMQASK 432
            |.....:||.:.....|:.....|    ||.:..||:...|..|       :::.........|.
Mouse   448 KPHHPNTEPVLGLSQTPISQQSLPLHMIPPSQVDDLSSPAKRKR-------TSSPTKNTSDNWSG 505

  Fly   433 GGAPKKPQSPP---------MTPKE----TLLRLPQDNLNNSNKLLIQEI 469
            |.||     ||         :||::    ..||..::|||.:.||:::::
Mouse   506 GNAP-----PPVEQQTHSWCLTPQKLQHLEQLRANRNNLNPAQKLMLEQL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	16/84 (19%)
		TPR repeat	229..257	CDD:276809	6/35 (17%)
		TPR repeat	262..293	CDD:276809	8/41 (20%)
		TPR_11	266..329	CDD:290150	15/70 (21%)
		TPR	266..297	CDD:197478	8/37 (22%)
		TPR repeat	298..326	CDD:276809	6/27 (22%)
Kdm6a	XP_006527657.1	TPR repeat	95..123	CDD:276809
		TPR	108..401	CDD:223533	53/266 (20%)
		TPR repeat	131..161	CDD:276809
		TPR repeat	166..196	CDD:276809	6/34 (18%)
		TPR repeat	207..235	CDD:276809	5/27 (19%)
		TPR repeat	287..314	CDD:276809	5/38 (13%)
		TPR repeat	319..349	CDD:276809	8/29 (28%)
		TPR repeat	354..380	CDD:276809	9/33 (27%)
		JmjC	1151..1215	CDD:214721
		JmjC	1185..1293	CDD:334913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900