Protein Alignment Spag1 and Stip1

DIOPT Version :10

• Sequence 1: NP_651514.1
• Gene: Spag1 / 43239
• FlyBaseID: FBgn0039463
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_058017.1
• Gene: Stip1 / 20867
• MGIID: 109130
• Length: 543
• Species: Mus musculus
• Alignment Length: 554
• Identity: 118/554 - (21%)
• Similarity: 192/554 - (34%)
• Gaps: 226/554 - (40%)

  Fly    34 MEKIVQILRSGEE----GHYPDLQRCAEEKLKALKPDSKLF----------------RYEEQIKQ 78
            ||::.::...|.:    |:..|..:|..|.:| |.|.:.:.                .||:..|
Mouse     1 MEQVNELKEKGNKALSAGNIDDALQCYSEAIK-LDPQNHVLYSNRSAAYAKKGDYQKAYEDGCK- 63

  Fly    79 STDLDKTELKPILDWTDAIKTKDNALN-----------------------ELKKVKQNL------ 114
                 ..:|||  ||......|..||.                       :||:..||:
Mouse    64 -----TVDLKP--DWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNLQLKEGLQNMEARLAE 121

  Fly   115 -------NLPSVRK--------------------------------------------------- 121
                   |||::.:
Mouse   122 RKFMNPFNLPNLYQKLENDPRTRSLLSDPTYRELIEQLQNKPSDLGTKLQDPRVMTTLSVLLGVD 186

  Fly   122 LSKIDLEKESKTEKPKPAPKATS---------PSNTKN--KEARIKSTDYRK--WDK----YDPD 169
            |..:|.|:|:.|..|.|.||...         |.|.|.  ||..:.:..|:|  :||    ||..
Mouse   187 LGSMDEEEEAATPPPPPPPKKEPKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDKALKHYDRA 251

  Fly   170 EEI----------------LRMDLNEERD---------QEQRE------KIISNHSKSVTTDKLQ 203
            :|:                .:.|.|:.|:         :|.||      |..:....|...::..
Mouse   252 KELDPTNMTYITNQAAVHFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKY 316

  Fly   204 SERDSLYERLQAQ------LKNLSQLE---KEQ---------FAERHRLRGNESFKAKEYENAIE 250
            .:....|.:..|:      ||...|.|   |||         .|...:.:|||.|:..:|..|::
Mouse   317 KDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMK 381

  Fly   251 EYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHL 315
            .|..:|..:|.:| ..|:|||..:.||.::..|:.||:.|:|::|..||.:.|.|.|..|...:.
Mouse   382 HYTEAIKRNPRDA-KLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYT 445

  Fly   316 ESLNVYKKLLDFE-----------------------PDN----AIAKKAVEKLTSMLGEVAPSSA 353
            ::::||:|.||.:                       |::    |:|...|:::.|       ..|
Mouse   446 KAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMS-------DPA 503

  Fly   354 TRLIIEEI--DPPQLKTSEPKKEAEKSEPTVVKK 385
            .|||:|::  ||..|  ||..|     .|.:.:|
Mouse   504 MRLILEQMQKDPQAL--SEHLK-----NPVIAQK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	NlpI	<229..373	CDD:443815	49/172 (28%)
		TPR repeat	229..257	CDD:276809	8/27 (30%)
		TPR repeat	262..293	CDD:276809	11/30 (37%)
		TPR repeat	298..326	CDD:276809	9/27 (33%)
Stip1	NP_058017.1	TPR 1	4..37		8/33 (24%)
		3a0801s09	<7..532	CDD:273380	116/548 (21%)
		TPR repeat	7..32	CDD:276809	5/24 (21%)
		TPR repeat	37..67	CDD:276809	3/35 (9%)
		TPR 2	39..71		6/39 (15%)
		TPR repeat	72..100	CDD:276809	3/27 (11%)
		TPR 3	73..105		3/31 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..233		13/41 (32%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	222..239		4/16 (25%)
		TPR 4	225..258		9/32 (28%)
		TPR repeat	229..253	CDD:276809	6/23 (26%)
		TPR repeat	258..288	CDD:276809	3/29 (10%)
		TPR 5	260..292		3/31 (10%)
		TPR 6	300..333		4/32 (13%)
		TPR repeat	300..328	CDD:276809	3/27 (11%)
		TPR 7	360..393		10/32 (31%)
		TPR repeat	364..388	CDD:276809	7/23 (30%)
		TPR repeat	393..423	CDD:276809	11/30 (37%)
		TPR 8	395..427		12/31 (39%)
		TPR 9	428..461		11/32 (34%)
		TPR repeat	428..456	CDD:276809	9/27 (33%)