DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spag1 and LONRF2

DIOPT Version :9

Sequence 1:NP_651514.1 Gene:Spag1 / 43239 FlyBaseID:FBgn0039463 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_940863.3 Gene:LONRF2 / 164832 HGNCID:24788 Length:754 Species:Homo sapiens


Alignment Length:267 Identity:57/267 - (21%)
Similarity:102/267 - (38%) Gaps:71/267 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 RLQAQLKNLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYNCSIIYDPENAVHAYNNRAVAHLK 276
            ||..|.::   |:::|..|...||.:::.:....:|::      ::.           ||..:|.
Human   199 RLAGQARS---LQRQQQPEAALLRCDQALELAPDDNSL------LLL-----------RAELYLT 243

  Fly   277 LKKYFSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKLLDFEPD-NAIAKKAVEK 340
            :|.|..|:.|..|..|.:|:.||.|...|:|.:..|:..|.|..:...|...|: |::.|:|.:.
Human   244 MKNYEQALQDASAACQNEPLLIKGHQVKAQALSGLGRSKEVLKEFLYCLALNPECNSVKKEAQKV 308

  Fly   341 LTSML--------GEVAPSSATRL------------IIEEIDPPQLKTS---------------- 369
            :..:|        ..:..|..:||            ::||.|....:.|                
Human   309 MCEVLFSATANVHENLTSSIQSRLKAQGHSHMNAQALLEEGDAGSSENSSEKSDMLGNTNSSVLY 373

  Fly   370 --------EPKKEAEKSEPTVVKKPEPVVSAKKPPPIKDYDLAELVKPNRMVKSNLVSAAEALGN 426
                    |.||..|...||.     |....|:..|....|..:|..|.::.|.:| |...:..:
Human   374 FILGLHFEEDKKALESILPTA-----PSAGLKRQFPDDVEDAPDLNAPGKIPKKDL-SLQRSPNS 432

  Fly   427 KMQASKG 433
            :.:.|:|
Human   433 ETEESQG 439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spag1NP_651514.1 TPR_11 229..295 CDD:290150 13/65 (20%)
TPR repeat 229..257 CDD:276809 4/27 (15%)
TPR repeat 262..293 CDD:276809 8/30 (27%)
TPR_11 266..329 CDD:290150 19/62 (31%)
TPR 266..297 CDD:197478 10/30 (33%)
TPR repeat 298..326 CDD:276809 8/27 (30%)
LONRF2NP_940863.3 TPR 1 23..58
TPR_16 27..92 CDD:372602
TPR 2 59..91
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..136
RING1-HC_LONFs 143..174 CDD:319427
TPR 3 197..230 8/33 (24%)
TPR repeat 200..225 CDD:276809 7/27 (26%)
TPR repeat 230..260 CDD:276809 9/46 (20%)
TPR 4 231..264 11/49 (22%)
TPR repeat 265..293 CDD:276809 8/27 (30%)
TPR 5 266..298 9/31 (29%)
PEX10 <380..489 CDD:227861 17/66 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..439 9/41 (22%)
RING2-HC_LONFs 446..487 CDD:319428
TPR 6 447..483
RING-HC finger (C3HC4-type) 449..486 CDD:319428
LON_substr_bdg 538..738 CDD:366967
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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