DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spag1 and DNAAF4

DIOPT Version :9

Sequence 1:NP_651514.1 Gene:Spag1 / 43239 FlyBaseID:FBgn0039463 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_570722.2 Gene:DNAAF4 / 161582 HGNCID:21493 Length:420 Species:Homo sapiens


Alignment Length:358 Identity:96/358 - (26%)
Similarity:145/358 - (40%) Gaps:96/358 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EKEKKK--SLLERYNIPIHYLDFAHVEKCTNAREMEKIVQILRSGEEGHYPDLQRCAEEKLKALK 64
            |:|:||  .:.|...|           |.|.|.|..|              :.||.|||: |.::
Human   138 EEERKKIEDMKENERI-----------KATKALEAWK--------------EYQRKAEEQ-KKIQ 176

  Fly    65 PDSKLFRYEEQIKQSTDLDKTELKPILDWTDAIKTKDNALNELKKVKQNL---NL-PSVRKLSKI 125
            .:.||.:.|:|||:       |.|.|               :.|.:.:||   || |..|....|
Human   177 REEKLCQKEKQIKE-------ERKKI---------------KYKSLTRNLASRNLAPKGRNSENI 219

  Fly   126 DLEKESKTEKPKPAPKATSPSNTKNKEARIKSTDYRKWDKYDPDEEILRMDLNEERDQEQREKII 190
            ..||  ..|...|||::.. |...|...|:..|..|: .:...:||.|      .:..|.|    
Human   220 FTEK--LKEDSIPAPRSVG-SIKINFTPRVFPTALRE-SQVAEEEEWL------HKQAEAR---- 270

  Fly   191 SNHSKSVTTDKLQSERDSLYERLQAQLKNLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYNCS 255
                :::.||             .|:|.:|.  |:|:..|..:.:||:.|..:.|..||..||.:
Human   271 ----RAMNTD-------------IAELCDLK--EEEKNPEWLKDKGNKLFATENYLAAINAYNLA 316

  Fly   256 IIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQI------DPMN--IKAHLRMAEAHNAEG 312
            |..:.:..: .|.|||..|||||....||.|....|::      |..|  :|||:|...|.....
Human   317 IRLNNKMPL-LYLNRAACHLKLKNLHKAIEDSSKALELLMPPVTDNANARMKAHVRRGTAFCQLE 380

  Fly   313 KHLESLNVYKKLLDFEPDNAIAKKAVEKLTSML 345
            .::|.|..|:..|..:|.|.|.:...||:.:::
Human   381 LYVEGLQDYEAALKIDPSNKIVQIDAEKIRNVI 413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spag1NP_651514.1 TPR_11 229..295 CDD:290150 23/71 (32%)
TPR repeat 229..257 CDD:276809 9/27 (33%)
TPR repeat 262..293 CDD:276809 13/30 (43%)
TPR_11 266..329 CDD:290150 24/70 (34%)
TPR 266..297 CDD:197478 14/36 (39%)
TPR repeat 298..326 CDD:276809 8/27 (30%)
DNAAF4NP_570722.2 Mediates interaction with ESR1 and STUB1. /evidence=ECO:0000269|PubMed:19423554 7..103
p23_DYX1C1_like 10..87 CDD:107226
TPR_11 289..353 CDD:290150 23/64 (36%)
TPR 1 290..323 10/32 (31%)
TPR repeat 290..318 CDD:276809 9/27 (33%)
TPR repeat 323..353 CDD:276809 13/30 (43%)
TPR 2 324..357 13/33 (39%)
TPR repeat 364..394 CDD:276809 8/29 (28%)
TPR 3 366..399 10/32 (31%)
TPR_1 367..399 CDD:278916 10/31 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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