DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spag1 and DNAAF4

DIOPT Version :10

Sequence 1:NP_651514.1 Gene:Spag1 / 43239 FlyBaseID:FBgn0039463 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_570722.2 Gene:DNAAF4 / 161582 HGNCID:21493 Length:420 Species:Homo sapiens


Alignment Length:358 Identity:96/358 - (26%)
Similarity:145/358 - (40%) Gaps:96/358 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EKEKKK--SLLERYNIPIHYLDFAHVEKCTNAREMEKIVQILRSGEEGHYPDLQRCAEEKLKALK 64
            |:|:||  .:.|...|           |.|.|.|..|              :.||.|||: |.::
Human   138 EEERKKIEDMKENERI-----------KATKALEAWK--------------EYQRKAEEQ-KKIQ 176

  Fly    65 PDSKLFRYEEQIKQSTDLDKTELKPILDWTDAIKTKDNALNELKKVKQNL---NL-PSVRKLSKI 125
            .:.||.:.|:|||:       |.|.|               :.|.:.:||   || |..|....|
Human   177 REEKLCQKEKQIKE-------ERKKI---------------KYKSLTRNLASRNLAPKGRNSENI 219

  Fly   126 DLEKESKTEKPKPAPKATSPSNTKNKEARIKSTDYRKWDKYDPDEEILRMDLNEERDQEQREKII 190
            ..||  ..|...|||::.. |...|...|:..|..|: .:...:||.|      .:..|.|    
Human   220 FTEK--LKEDSIPAPRSVG-SIKINFTPRVFPTALRE-SQVAEEEEWL------HKQAEAR---- 270

  Fly   191 SNHSKSVTTDKLQSERDSLYERLQAQLKNLSQLEKEQFAERHRLRGNESFKAKEYENAIEEYNCS 255
                :::.||             .|:|.:|.  |:|:..|..:.:||:.|..:.|..||..||.:
Human   271 ----RAMNTD-------------IAELCDLK--EEEKNPEWLKDKGNKLFATENYLAAINAYNLA 316

  Fly   256 IIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQI------DPMN--IKAHLRMAEAHNAEG 312
            |..:.:..: .|.|||..|||||....||.|....|::      |..|  :|||:|...|.....
Human   317 IRLNNKMPL-LYLNRAACHLKLKNLHKAIEDSSKALELLMPPVTDNANARMKAHVRRGTAFCQLE 380

  Fly   313 KHLESLNVYKKLLDFEPDNAIAKKAVEKLTSML 345
            .::|.|..|:..|..:|.|.|.:...||:.:::
Human   381 LYVEGLQDYEAALKIDPSNKIVQIDAEKIRNVI 413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spag1NP_651514.1 NlpI <229..373 CDD:443815 39/125 (31%)
TPR repeat 229..257 CDD:276809 9/27 (33%)
TPR repeat 262..293 CDD:276809 13/30 (43%)
TPR repeat 298..326 CDD:276809 8/27 (30%)
DNAAF4NP_570722.2 Mediates interaction with ESR1 and STUB1. /evidence=ECO:0000269|PubMed:19423554 7..103
p23_DYX1C1_like 10..87 CDD:107226
TPR 1 290..323 10/32 (31%)
TPR repeat 290..318 CDD:276809 9/27 (33%)
NlpI <297..>399 CDD:443815 34/102 (33%)
TPR repeat 323..353 CDD:276809 13/30 (43%)
TPR 2 324..357 13/33 (39%)
TPR repeat 364..394 CDD:276809 8/29 (28%)
TPR 3 366..399 10/32 (31%)
Blue background indicates that the domain is not in the aligned region.

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